Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000391.1:
Cluster 1NRP114231

BGC0000391, methylpendolmycin/pendolmycin biosynthetic gene cluster from Marinactinospora thermotolerans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: methylpendolmycin
SMILES string: Copy to clipboard
Molecular formula: C23H33N3O2
Exact molecular mass: 383.26 Da (M+)
Molecular activity: Cytotoxic, Signalling

Class-specific details

Biosynthetic class(es):
Other (cyclic)
Thioesterase type:
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
mpnB (AFO85453.1)
Module 1
A specificity: Isoleucine
Evidence for specificity: Other
C domain subtype: LCL
Scaffold-modifying domain: Methylation

Gene cluster description

methylpendolmycin/pendolmycin (BGC0000391). Gene Cluster 1. Biosynthetic class = NRP. GenBank JN634585, positions 1146-12291. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Jianhua Ju (South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS))

Literature references

1. Ma J et al. (2012) Characterization of a single gene cluster responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. Chembiochem 13(4):547-52. doi: 10.1002/cbic.201100700. Epub 2012 Feb