BGC0000391: methylpendolmycin biosynthetic gene cluster from Marinactinospora thermotolerans
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Location: 1 - 14,231 nt. (total: 14,231 nt).
This entry is originally from NCBI GenBank JN634585.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000391
Short description methylpendolmycin biosynthetic gene cluster from Marinactinospora thermotolerans
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: JN634585.1
Compounds
  • methylpendolmycin
  • pendolmycin
Species Marinactinospora thermotolerans [taxonomy]
References
Chemical products information
methylpendolmycin
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C23H33N3O2
pendolmycin
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C22H31N3O2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFO85452.1
 1 - 732 (+) N-acetylglucosaminylphosphatidylinositol deacetylase
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  • AFO85453.1
 1146 - 9767 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
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  • AFO85454.1
 9764 - 11110 (+) P450-like monoxygenase
  • Tailoring (Heterocyclization)
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  • AFO85455.1
 11167 - 12291 (+) aromatic prenyltransferase
  • Tailoring (Prenylation)
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  • AFO85456.1
 12357 - 13109 (+) reductase/oxidase
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  • AFO85457.1
 13133 - 13654 (+) Isopentenyl-diphosphate delta-isomerase
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  • AFO85458.1
 13713 - 14231 (+) Acetyltransferase
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NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Reductive release
NRP-synthases
Gene Modules
AFO85453.1
Module 1
Specificity: isoleucine / valine
Evidence for specificity:
Condensation domain type: LCL
Modification domains: Methylation
Module 2
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AADADFAEMFE2AOMR24EUYNFH, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP module
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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