BGC0000392: mirubactin biosynthetic gene cluster from Actinosynnema mirum DSM 43827
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Location: 3,113,324 - 3,141,040 nt. (total: 27,717 nt).
This entry is originally from NCBI GenBank CP001630.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000392
Short description mirubactin biosynthetic gene cluster from Actinosynnema mirum DSM 43827
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP001630.1
3113324 - 3141040
via
Compounds
  • mirubactin
Species Actinosynnema mirum DSM 43827 [taxonomy]
References
Chemical products information
mirubactin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Amir_2714
  • ACU36649.1
 3113324 - 3113875 (-) transcriptional regulator, TetR family
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    • Amir_2715
    • ACU36650.1
    		 3113968 - 3114873 (+) Luciferase-like monooxygenase
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      • Amir_2716
      • ACU36651.1
      		 3114940 - 3117765 (-) transcriptional regulator, LuxR family
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        • Amir_2717
        • ACU36652.1
        		 3118394 - 3119455 (-) phospho-2-dehydro-3-deoxyheptonate aldolase
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          • Amir_2718
          • ACU36653.1
          		 3119448 - 3120851 (-) drug resistance transporter, EmrB/QacA subfamily
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            • Amir_2719
            • ACU36654.1
            		 3120848 - 3131080 (-) amino acid adenylation domain protein
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              • Amir_2720
              • ACU36655.1
              		 3131153 - 3131938 (-) ABC transporter related
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                • Amir_2721
                • ACU36656.1
                		 3131935 - 3132951 (-) transport system permease protein
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                  • Amir_2722
                  • ACU36657.1
                  		 3132948 - 3133946 (-) transport system permease protein
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                    • Amir_2723
                    • ACU36658.1
                    		 3133943 - 3134965 (-) periplasmic binding protein
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                      • Amir_2724
                      • ACU36659.1
                      		 3135012 - 3135947 (-) Siderophore-interacting protein
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                        • Amir_2726
                        • ACU36660.1
                        		 3136848 - 3138524 (-) AMP-dependent synthetase and ligase
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                          • Amir_2727
                          • ACU36661.1
                          		 3138521 - 3140032 (-) isochorismate synthase
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                            • Amir_2728
                            • ACU36662.1
                            		 3140270 - 3141040 (-) short-chain dehydrogenase/reductase SDR
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              Amir_2719
                              Substrates
                              arginine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              Amir_2719
                              Substrates
                              N5-formyl-N5-hydroxyornithine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              Amir_2726
                              Substrates
                              2,3-dihydroxybenzoic acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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