BGC0000393: myxoprincomide-c506 biosynthetic gene cluster from Myxococcus xanthus DK 1622
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Location: 4,498,820 - 4,546,737 nt. (total: 47,918 nt).
This entry is originally from NCBI GenBank CP000113.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000393
Short description myxoprincomide-c506 biosynthetic gene cluster from Myxococcus xanthus DK 1622
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
CP000113.1
4498820 - 4546737
via Knock-out studies
Compounds
  • myxoprincomide-c506
Species Myxococcus xanthus DK 1622 [taxonomy]
References
Chemical products information
myxoprincomide-c506 Evidence:
Copy SMILES
C45H74N10O16
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MXAN_3778
  • ABF85909.1
 4498820 - 4501138 (+) DnaK family protein
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    • MXAN_3779
    • ABF87031.1
    		 4501281 - 4544105 (+) non-ribosomal peptide synthetase/polyketide synthase
    • Scaffold biosynthesis
    • Knock-out
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    • MXAN_3780
    • ABF87987.1
    		 4544092 - 4546737 (-) patatin-like phospholipase family protein
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      Biosynthesis information

      Biosynthetic modules

      Name
      1
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      serine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation, methyltransferase
      Name
      2
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      leucine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      3
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      3-hydroxyvaline (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      4
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      serine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      5
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      valine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      8
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      serine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      9
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      tyrosine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      10
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      beta-lysine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      12
      Type
      nrps-type1
      Genes
      MXAN_3779
      Substrates
      alanine (evidence: Structure-based inference [1])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      6
      Type
      pks-modular
      Genes
      MXAN_3779
      Substrates
      Integrated Monomers
      Domains
      acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
      Annotation changelog

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Removed ketoreductase stereochemistry annotation from modules without ketoreductases
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Corrected NRP gene names
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated bioactivity data
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated NRP substrate specificities
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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