Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000393.1:
Cluster 1NRP / Polyketide147918

BGC0000393, myxoprincomide biosynthetic gene cluster from Myxococcus xanthus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Myxoprincomide-c506
SMILES string: Copy to clipboard
Molecular formula: C45H74O16N10
Exact molecular mass: 1011.53568 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
mxp (MXAN_3779)
Module 0
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: Unknown
Module is skipped
Evidence for skipping: Unknown
Module 1
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 2
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 3
A specificity: bOH-Val
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster:
C domain subtype: LCL
Module 4
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 5
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 8
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Tyrosine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 10
A specificity: bLys
Evidence for specificity: Structure-based inference
Amino acid biosynthesis subcluster:
C domain subtype: LCL
Module 11
A specificity: None
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module is skipped
Evidence for skipping: Unknown
Module 12
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Unknown
Thioesterase type:
None
Release / cyclization type:
Unknown

Modular polyketide synthases:
mxp (MXAN_3779)
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference

Gene cluster description

myxoprincomide (BGC0000393). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP000113, positions 4498820-4546737. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Daniel Krug (Helmholtz Institute for Pharmaceutical Research Saarland)

Literature references

1. Cortina NS et al. (2012) Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome. Angew Chem Int Ed Engl 51(3):811-6. doi: 10.1002/anie.201106305.