BGC0000393: myxoprincomide-c506 biosynthetic gene cluster from Myxococcus xanthus DK 1622
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Location: 4,498,820 - 4,546,737 nt. (total: 47,918 nt).
This entry is originally from NCBI GenBank CP000113.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000393
Short description myxoprincomide-c506 biosynthetic gene cluster from Myxococcus xanthus DK 1622
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: CP000113.1
Compounds
  • myxoprincomide-c506
Species Myxococcus xanthus DK 1622 [taxonomy]
References
Chemical products information
myxoprincomide-c506
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C45H74N10O16
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MXAN_3778
  • ABF85909.1
 4498820 - 4501138 (+) DnaK family protein
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  • MXAN_3779
  • ABF87031.1
 4501281 - 4544105 (+) non-ribosomal peptide synthetase/polyketide synthase
  • Scaffold biosynthesis
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  • MXAN_3780
  • ABF87987.1
 4544092 - 4546737 (-) patatin-like phospholipase family protein
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Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
MXAN_3779 Synthase subclass: Modular type I
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: MXAN_3779
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
Thioesterase genes
  • MXAN_3779 (Type I)
NRP-synthases
Gene Modules
MXAN_3779
Module 0 [inactive]
Condensation domain type: Unknown
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 1
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 2
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: 3-hydroxyvaline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 4
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 8
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 9
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 10
Specificity: beta-lysine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 11 [inactive]
Condensation domain type: LCL
Non-canonical activity:
  • Other
Evidence for non-canonical activity:
  • Structure-based inference
Module 12
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected NRP gene names
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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