BGC0000394: naphthyridinomycin biosynthetic gene cluster from Streptomyces lusitanus
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Location: 1 - 51,977 nt. (total: 51,977 nt).
This entry is originally from NCBI GenBank JQ996389.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000394
Short description naphthyridinomycin biosynthetic gene cluster from Streptomyces lusitanus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: JQ996389.1
Compounds
  • naphthyridinomycin
Species Streptomyces lusitanus [taxonomy]
References
Chemical products information
naphthyridinomycin
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C21H27N3O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGD80606.1
 1 - 2493 (+) UV-repair protein
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  • AGD80607.1
 2534 - 3799 (-) membrane protein
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  • AGD80608.1
 3812 - 5290 (-) monooxygenase
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  • AGD80609.1
 5586 - 6602 (+) thiamin diphosphate binding domain of transketolase
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  • AGD80610.1
 6590 - 6847 (+) acyl carrier protein
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  • AGD80611.1
 6844 - 9018 (+) transketolase
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  • AGD80612.1
 9114 - 10118 (+) 3-oxoacyl-synthase III
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  • AGD80613.1
 10186 - 10698 (+) hypothetical protein
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  • AGD80614.1
 10806 - 13259 (-) peptidase
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  • AGD80615.1
 13240 - 15228 (-) regulatory protein
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  • AGD80616.1
 15407 - 18046 (-) amino acid adenylation domain-containing protein
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  • AGD80617.1
 18127 - 19131 (-) non-heme iron hydroxylase
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  • AGD80618.1
 19203 - 23657 (-) non-ribosomal peptide synthetase
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  • AGD80619.1
 23690 - 23890 (-) MbtH-like protein
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  • AGD80620.1
 23936 - 27043 (-) non-ribosomal peptide synthetase
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  • AGD80621.1
 27040 - 27813 (-) thioesterase II
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  • AGD80622.1
 28146 - 30125 (+) AMP-dependent synthetase and ligase
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  • AGD80623.1
 30195 - 39491 (+) non-ribosomal peptide synthetase
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  • AGD80633.1
 39551 - 40276 (+) hypothetical protein
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  • AGD80624.1
 40370 - 41425 (+) hydroxylase
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  • AGD80625.1
 41593 - 42657 (+) SAM-dependent methyltransferase
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  • AGD80626.1
 42817 - 43863 (+) SAM-dependent methyltransferase
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  • AGD80627.1
 44009 - 45598 (+) transmembrane-transport protein
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  • AGD80628.1
 45924 - 47546 (+) oxidoreductase
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  • AGD80629.1
 47564 - 48733 (+) methyltransferase
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  • AGD80630.1
 48891 - 49826 (-) short chain dehydrogenase
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  • AGD80631.1
 50332 - 51018 (-) phosphopantetheinyl transferase
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  • AGD80632.1
 51312 - 51977 (-) transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AGD80616.1
Module ?
Specificity: beta-hydroxy-3-hydroxy-O-methyl-5-methyltyrosine
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
AGD80623.1
Module ?
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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