BGC0000394: naphthyridinomycin biosynthetic gene cluster from Streptomyces lusitanus
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Location: 1 - 51,977 nt. (total: 51,977 nt).
This entry is originally from NCBI GenBank JQ996389.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000394
Short description naphthyridinomycin biosynthetic gene cluster from Streptomyces lusitanus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JQ996389.1
via
Compounds
  • naphthyridinomycin
Species Streptomyces lusitanus [taxonomy]
References
Chemical products information
naphthyridinomycin Evidence:
Copy SMILES
C21H27N3O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGD80606.1
 1 - 2493 (+) UV-repair protein
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    • AGD80607.1
    		 2534 - 3799 (-) membrane protein
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      • AGD80608.1
      		 3812 - 5290 (-) monooxygenase
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        • AGD80609.1
        		 5586 - 6602 (+) thiamin diphosphate binding domain of transketolase
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          • AGD80610.1
          		 6590 - 6847 (+) acyl carrier protein
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            • AGD80611.1
            		 6844 - 9018 (+) transketolase
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              • AGD80612.1
              		 9114 - 10118 (+) 3-oxoacyl-synthase III
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                • AGD80613.1
                		 10186 - 10698 (+) hypothetical protein
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                  • AGD80614.1
                  		 10806 - 13259 (-) peptidase
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                    • AGD80615.1
                    		 13240 - 15228 (-) regulatory protein
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                      • AGD80616.1
                      		 15407 - 18046 (-) amino acid adenylation domain-containing protein
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                        • AGD80617.1
                        		 18127 - 19131 (-) non-heme iron hydroxylase
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                          • AGD80618.1
                          		 19203 - 23657 (-) non-ribosomal peptide synthetase
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                            • AGD80619.1
                            		 23690 - 23890 (-) MbtH-like protein
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                              • AGD80620.1
                              		 23936 - 27043 (-) non-ribosomal peptide synthetase
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                                • AGD80621.1
                                		 27040 - 27813 (-) thioesterase II
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                                  • AGD80622.1
                                  		 28146 - 30125 (+) AMP-dependent synthetase and ligase
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                                    • AGD80623.1
                                    		 30195 - 39491 (+) non-ribosomal peptide synthetase
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                                      • AGD80633.1
                                      		 39551 - 40276 (+) hypothetical protein
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                                        • AGD80624.1
                                        		 40370 - 41425 (+) hydroxylase
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                                          • AGD80625.1
                                          		 41593 - 42657 (+) SAM-dependent methyltransferase
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                                            • AGD80626.1
                                            		 42817 - 43863 (+) SAM-dependent methyltransferase
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                                              • AGD80627.1
                                              		 44009 - 45598 (+) transmembrane-transport protein
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                                                • AGD80628.1
                                                		 45924 - 47546 (+) oxidoreductase
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                                                  • AGD80629.1
                                                  		 47564 - 48733 (+) methyltransferase
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                                                    • AGD80630.1
                                                    		 48891 - 49826 (-) short chain dehydrogenase
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                                                      • AGD80631.1
                                                      		 50332 - 51018 (-) phosphopantetheinyl transferase
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                                                        • AGD80632.1
                                                        		 51312 - 51977 (-) transcriptional regulator
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                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          Unk01
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          AGD80616.1
                                                          Substrates
                                                          beta-hydroxy-3-hydroxy-O-methyl-5-methyltyrosine (evidence: Structure-based inference, Knock-out studies)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk02
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          AGD80623.1
                                                          Substrates
                                                          alanine (evidence: Sequence-based prediction [1])
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk03
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          AGD80623.1
                                                          Substrates
                                                          alanine (evidence: Sequence-based prediction [1])
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk04
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          AGD80623.1
                                                          Substrates
                                                          alanine (evidence: Sequence-based prediction [1])
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Annotation changelog

                                                          Entry version: 4

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Added NRP substrate specificities
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Migrated from v1.4
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2019-10-16
                                                          Updated compound(s) information (NPAtlas curation)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2015-06-12
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          Detailed domain annotation
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