BGC0000395 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000395 (Nocardia uniformis subsp. tsuyamanensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	33,451	nocardicin A	NRPS:Type I	100%

BGC0000395 - Region 1 - NRPS

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Location: 1 - 33,451 nt. (total: 33,451 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,452
Label		BGC0000395

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000395	1.00	NRP	nocardicin A	Nocardia uniformis subsp. tsuyamanensis
BGC0001133	0.38	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.36	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002631	0.33	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000457	0.33	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002031	0.33	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001878	0.32	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0002208	0.32	NRP	oxepinamide F	Aspergillus ustus
BGC0000401	0.32	NRP	paenibactin	Paenibacillus elgii B69
BGC0001890	0.32	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000395	1.00	NRP	nocardicin A	Nocardia uniformis subsp. tsuyamanensis
BGC0001133	0.71	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.69	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000457	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002031	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001878	0.66	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0002208	0.65	NRP	oxepinamide F	Aspergillus ustus
BGC0000401	0.65	NRP	paenibactin	Paenibacillus elgii B69
BGC0001890	0.65	NRP	amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4	Vibrio campbellii ATCC BAA-1116

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 33451:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Hpg - Arg - D-Hpg) + (Ser - Hpg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

nocA

Search NORINE for peptide: strict or relaxed

AMP-binding (32..440): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWHVGAITK
Nearest Stachelhaus code(s):: Hpg DIWHVGAITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1139..1537): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVENVGAIGK
Nearest Stachelhaus code(s):: Arg DVENVGAIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2249..2634): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWHVGTIIK
Nearest Stachelhaus code(s):: Hpg DIWHVGTIIK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

nocB

Search NORINE for peptide: strict or relaxed

AMP-binding (40..442): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHISLIDK
Nearest Stachelhaus code(s):: Ser DVWHISLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1119..1513): Hpg

nrpys: Hpg

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIWHLGAISK
Nearest Stachelhaus code(s):: Hpg DIWHLGAISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)