BGC0000395: nocardicin A biosynthetic gene cluster from Nocardia uniformis subsp. tsuyamanensis
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Location: 1 - 33,451 nt. (total: 33,451 nt).
This entry is originally from NCBI GenBank AY541063.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000395
Short description nocardicin A biosynthetic gene cluster from Nocardia uniformis subsp. tsuyamanensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AY541063.1
Compounds
  • nocardicin A
Species Nocardia uniformis subsp. tsuyamanensis [taxonomy]
References
Chemical products information
nocardicin A
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C23H24N4O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAT09795.1
  • nocN
 102 - 1232 (+) NocN
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  • AAT09796.1
  • nocR
 1325 - 3073 (+) NocR
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  • AAT09797.1
  • nocL
 3103 - 4299 (+) NocL
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  • AAT09798.1
  • nocK
 4322 - 5356 (-) NocK
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  • AAT09799.1
  • nocJ
 5359 - 6342 (-) NocJ
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  • AAT09800.1
  • nocI
 6363 - 6584 (-) NocI
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  • AAT09801.1
  • nocH
 6685 - 7911 (+) NocH
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  • AAT09802.1
  • nocG
 7945 - 9240 (-) NocG
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  • AAT09803.1
  • nocF
 9256 - 10293 (-) NocF
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  • AAT09804.1
  • nocA
 10419 - 21497 (+) NocA
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  • AAT09805.1
  • nocB
 21494 - 27271 (+) NocB
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  • AAD46393.1
  • nat
 27268 - 28173 (+) nocardicin 3-amino-3-carboxypropyl transferase
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  • AAT09806.1
  • nocD
 28209 - 28766 (+) NocD
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  • AAT09807.1
  • nocE
 29161 - 33405 (+) NocE
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
nocA
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: arginine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
nocB
Module ?
Specificity: serine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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