BGC0000396 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000396 (Nostoc sp. 73.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	14,288	nodularin	NRPS:Type I	100%

BGC0000396 - Region 1 - NRPS

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Location: 1 - 14,288 nt. (total: 14,288 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,289
Label		BGC0000396

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000396	1.00	NRP	nodularin	Nostoc sp. 73.1
BGC0000465	0.40	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000426	0.34	NRP	sevadicin	Paenibacillus larvae
BGC0002135	0.31	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.31	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002518	0.30	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001132	0.28	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128	0.28	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.28	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825	0.28	NRP	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000396	1.00	NRP	nodularin	Nostoc sp. 73.1
BGC0000465	0.72	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0000426	0.67	NRP	sevadicin	Paenibacillus larvae
BGC0002135	0.64	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.64	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002518	0.63	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001132	0.62	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128	0.61	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135	0.61	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001825	0.61	NRP	xenematide	Xenorhabdus nematophila AN6/1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14288:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Thr - X) + (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ndaA

Search NORINE for peptide: strict or relaxed

AMP-binding (255..670): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2048..2472): X

nrpys: D-bMe-Asp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DARHVGIFVK
Nearest Stachelhaus code(s):: D-bMe-Asp DARHVGIFVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ndaB

Search NORINE for peptide: strict or relaxed

AMP-binding (475..872): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVWNFGFVDK
Nearest Stachelhaus code(s):: Ser DVWFFGLVDK (85% 8Å match); Leu or Arg DVWFFGLVDK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)