BGC0000397: nostocyclopeptide A2 biosynthetic gene cluster from Nostoc sp. ATCC 53789
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Location: 1 - 34,328 nt. (total: 34,328 nt).
This entry is originally from NCBI GenBank AY167420.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000397
Short description nostocyclopeptide A2 biosynthetic gene cluster from Nostoc sp. ATCC 53789
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AY167420.1
Compounds
  • nostocyclopeptide A2
Species Nostoc sp. ATCC 53789 [taxonomy]
References
Chemical products information
nostocyclopeptide A2
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C40H54N8O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAO23328.1
  • ncpE
 1175 - 1996 (-) NcpE
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  • AAO23329.1
  • ncpD
 2036 - 3142 (-) NcpD
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  • AAO23330.1
 3191 - 3988 (-) unknown
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  • AAO23331.1
 4090 - 5694 (-) penicillin-binding protein-like protein
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  • AAO23332.1
  • ncpC
 5793 - 7811 (-) NcpC
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  • AAO23333.1
  • ncpA
 8496 - 19703 (+) NcpA
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  • AAO23334.1
  • ncpB
 19700 - 34111 (+) NcpB
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ncpA
Module ?
Specificity: tyrosine / leucine / phenylalanine / alanine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
ncpB
Module ?
Specificity: isoleucine / methionine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4S-methylproline
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: leucine / phenylalanine
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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