LOCUS       BGC0000401             12882 bp    DNA     linear   BCT 18-OCT-2011
DEFINITION  Paenibacillus elgii B69 paebacillibactin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0000401
VERSION     BGC0000401
KEYWORDS    .
SOURCE      Paenibacillus elgii B69
  ORGANISM  Paenibacillus elgii B69
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:33:15
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..915
                     /gene="paeG"
     CDS             1..915
                     /codon_start=1
                     /gene="paeG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /product="paebacillibactin esterase"
                     /protein_id="AEI70240.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.9e-09, bitscore:
                     25.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSVAVQSVSIEGDGSIVAFKPNEQSEVTLKDLARGKVDIPWAE
                     QWIMKSRDHHRRYQILVARPPEAPPPAGFPVIYLLDANSVFGTMVEAVRLQSRRPDKTG
                     IVPAVIVGIGYPVDGPFAPERFYDLTPAATKEYLNRADSTPLPEQGGAAHFLKFIEEEL
                     KPQIEDEFPVDRSRQTIFGHSLGGLFVLYALFAKPHAFQSYIAGSPSLHWNESFLLEAE
                     REFAKGWQPEANRIELLLGVGEMEKTHVSRNCDRALALSERLAALSGRGLDVEYKEFEG
                     EGHVSVLPVLISRALRLALRPKP"
     source          1..12882
                     /db_xref="taxon:1007103"
                     /mol_type="genomic DNA"
                     /organism="Paenibacillus elgii B69"
                     /strain="B69"
     misc_feature    1..12882
                     /note="paebacillibactin biosynthesis gene cluster"
     protocluster    1..12882
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[5772:12882]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5773..12882
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     protocluster    1..12882
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[981:12882]"
                     /cutoff="30000"
                     /detection_rule="(VibH_like or Cy_tandem or
                     (cds(Condensation and AMP-binding) and ((IBH_Asp and not
                     SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or
                     CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD
                     and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox
                     and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))"
                     /neighbourhood="20000"
                     /product="NRP-metallophore"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      982..12882
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="30000"
                     /detection_rule="(VibH_like or Cy_tandem or
                     (cds(Condensation and AMP-binding) and ((IBH_Asp and not
                     SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or
                     CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD
                     and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox
                     and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))"
                     /neighbourhood="20000"
                     /product="NRP-metallophore"
                     /protocluster_number="2"
     cand_cluster    1..12882
                     /SMILES="NC(C)C(=O)NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(VibH_like or Cy_tandem or
                     (cds(Condensation and AMP-binding) and ((IBH_Asp and not
                     SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or
                     CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD
                     and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox
                     and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="chemical_hybrid"
                     /product="NRP-metallophore"
                     /product="NRPS"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..12882
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000401"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12882
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRP-metallophore"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(VibH_like or Cy_tandem or (cds(Condensation and
                     AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or
                     TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or
                     (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or
                     PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like))
                     or Lys_monoox or VbsL)))"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            982..1767
                     /gene="paeA"
     CDS             982..1767
                     /NRPS_PKS="Domain: PKS_KR (9-165). E-value: 1.2e-16. Score:
                     52.9. Matches aSDomain: nrpspksdomains_paeA_PKS_KR.1"
                     /codon_start=1
                     /gene="paeA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: EntA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     254; E-value: 2.5e-77)"
                     /gene_kind="biosynthetic"
                     /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase"
                     /protein_id="AEI70241.1"
                     /sec_met_domain="EntA (E-value: 2e-120, bitscore: 389.8,
                     seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.1e-41, bitscore:
                     130.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVELGIKGKVALVTGAAQGIGEAVARALAELGASVAALDRNADGL
                     GSLVAELNARGHQTAAYPADVSDSSAVEDAVERIERELGPIGILVNVAGVLRMGAIESY
                     SDEDWEATFAVNTKGVFYVSRAVVRRMALRRSGAIVTVGSNASGVPRMHMAAYAASKAA
                     STVFTKCLGLEHARHNIRCNIVSPGSTDTAMQRLLWADQSGEQAVIAGSAESFRLGIPL
                     GKLARPSDIADAVVFLVSDRAGHITMSDLCIDGGATLGK"
     aSDomain        1009..1476
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeA_PKS_KR.1"
                     /evalue="1.20E-16"
                     /label="paeA_PKS_KR.1"
                     /locus_tag="paeA"
                     /protein_end="165"
                     /protein_start="9"
                     /score="52.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGAAQGIGEAVARALAELGASVAALDRNADGLGSLVAELNA
                     RGHQTAAYPADVSDSSAVEDAVERIERELGPIGILVNVAGVLRMGAIESYSDEDWEATF
                     AVNTKGVFYVSRAVVRRMALRRSGAIVTVGSNASGVPRMHMAAYAASKAAST"
     CDS_motif       1015..1134
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeA_0001"
                     /evalue="3.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="paeA"
                     /protein_end="51"
                     /protein_start="11"
                     /score="16.4"
                     /tool="antismash"
                     /translation="LVTGAAQGIGEAVARALAELGASVAALDRNADGLGSLVAE"
     gene            1788..3056
                     /gene="paeC"
     CDS             1788..3056
                     /codon_start=1
                     /gene="paeC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: EntC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 407.8; E-value:
                     1.2e-123)"
                     /gene_kind="biosynthetic"
                     /product="isochorismate synthase"
                     /protein_id="AEI70242.1"
                     /sec_met_domain="EntC (E-value: 3e-157, bitscore: 512.5,
                     seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMDMVNLEAVPAAWASELIDMYEAGSSFFLASPQRTLLAKGEAAR
                     LSVQGGADRLKSLPQRVAELLARTQFSGGAPSVVVGAIPFDPAKPAELIVPQTARWAGK
                     LQLSSEAAERQADASDYKLRPVPEPEVYEHSVSRALARFQKGDLRKVVLGRTLHLTLPT
                     KVDVNRLLRNLARHNPHGYTFAVNLAPGEARAAWTPDKSNGQEPRTLIGASPELLVTRT
                     GGRLKANPLAGSAPRSSDPVEDRRRAEALLASAKDRHEHAVVIEAVADALRPYCTRLDV
                     PREPSLVQTSTMWHLSTVVTGELADPWASSLELALALHPTPAICGTPTDLAQETIRESE
                     PFDRGFFTGTVGWCDASGDGEWVVTIRCAEVEGRELRLFAGAGIVEGSSPQAELAETSA
                     KFRTLLQAMGLNQPQLAVVKGDK"
     gene            3053..4687
                     /gene="paeE"
     CDS             3053..4687
                     /NRPS_PKS="Domain: AMP-binding (34-437). E-value: 6.6e-88.
                     Score: 286.8. Matches aSDomain:
                     nrpspksdomains_paeE_AMP-binding.1"
                     /codon_start=1
                     /gene="paeE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     498.4; E-value: 3e-151)"
                     /gene_kind="biosynthetic-additional"
                     /product="2,3-dihydroxybenzoate-AMP ligase"
                     /protein_id="AEI70243.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-97, bitscore:
                     315.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRSQYPSWPKELADFYRETGCWQGETFGEMLRGRAAAYGDRIAV
                     VSGTSRISYAELDARVDRLAAGFYKLGIRQDDKVILQLPNIAEFIEVCFALFRLGALPV
                     FALPLHRRSEIVYFSEFTNANAYIIPDVEAGFDYRELAAQVQEQVPTLRHVIVAGDPGK
                     FTALRDLYADPLPDLPGPSSDDVAFLQLSGGSTGLPKLIPRTHDDYIYSLRMSAEVCAL
                     DEQSIYLAVLPAAHNYPLSSPGVLGTLYAGGRVVLSRGSSPDEAFPLIERERVTITAVV
                     PPLALVWLDAAESRRSDLSSLRLLQVGGAKFSAEAARKVKPMLGCTLQQVFGMAEGLVN
                     YTRPDDPEEIVVNTQGRPMSPYDEIRIVDDEDEEVAPGQVGHLLTRGPYTIRGYYKAEE
                     HNARAFTADGFYRTGDMARMTPEGYLVVEGRAKDQINRGGDKVAAEEVENHLLAHPGVH
                     DAAVVSMPDAYLGERSCAFIVPYSPAPTPAELKAFLRERGLAAYKIPDRVEFMESFPRT
                     GVGKISKKALRELIEQKQQALAAPPIK"
     aSDomain        3155..4363
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeE_AMP-binding.1"
                     /evalue="6.60E-88"
                     /label="paeE_AMP-binding.1"
                     /locus_tag="paeE"
                     /protein_end="437"
                     /protein_start="34"
                     /score="286.8"
                     /specificity="substrate consensus: diOH-Bz"
                     /tool="antismash"
                     /translation="RAAAYGDRIAVVSGTSRISYAELDARVDRLAAGFYKLGIRQDDKV
                     ILQLPNIAEFIEVCFALFRLGALPVFALPLHRRSEIVYFSEFTNANAYIIPDVEAGFDY
                     RELAAQVQEQVPTLRHVIVAGDPGKFTALRDLYADPLPDLPGPSSDDVAFLQLSGGSTG
                     LPKLIPRTHDDYIYSLRMSAEVCALDEQSIYLAVLPAAHNYPLSSPGVLGTLYAGGRVV
                     LSRGSSPDEAFPLIERERVTITAVVPPLALVWLDAAESRRSDLSSLRLLQVGGAKFSAE
                     AARKVKPMLGCTLQQVFGMAEGLVNYTRPDDPEEIVVNTQGRPMSPYDEIRIVDDEDEE
                     VAPGQVGHLLTRGPYTIRGYYKAEEHNARAFTADGFYRTGDMARMTPEGYLVVEGRAKD
                     QINR"
     CDS_motif       4181..4267
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeE_0001"
                     /evalue="1.50E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="paeE"
                     /protein_end="405"
                     /protein_start="376"
                     /score="11.0"
                     /tool="antismash"
                     /translation="PGQVGHLLTRGPYTIRGYYKAEEHNARAF"
     gene            4709..5671
                     /gene="paeB"
     CDS             4709..5671
                     /NRPS_PKS="Domain: PP-binding (238-300). E-value: 5.4e-11.
                     Score: 34.8. Matches aSDomain:
                     nrpspksdomains_paeB_PP-binding.1"
                     /codon_start=1
                     /gene="paeB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 390.1; E-value:
                     6.4e-119)"
                     /gene_kind="biosynthetic-additional"
                     /product="isochorismatase"
                     /protein_id="AEI70244.1"
                     /sec_met_domain="PP-binding (E-value: 5.8e-12, bitscore:
                     34.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALPAITPYPMPTASDLPANRVNWIPDPKRAVLLIHDMQQYFVDA
                     FTEGASPVIELLENIRTLRNACDELGIPVVYSAQPGGQTLEQRGLLQDFWGPGINDGPY
                     QKQIIKELPPGERDIVLTKWRYSAFQKTDFRARLTQLGRDQLIVCGIYAHIGCLMTSCE
                     AFMQEVEPFFVADAVADFSLEKHRLAITYAAERCAVVMTTERLIKALRGEAGASAEPEA
                     ASEAAPAAESGSLTKDGLRELVADLLQEAPSSIAEHDNLITHWGLDSIRIMSLAERWRR
                     SGAEVTFVELAERPTLADWFALLSARLSRTLPNGDYITT"
     aSDomain        5423..5608
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeB_PP-binding.1"
                     /evalue="5.40E-11"
                     /label="paeB_PP-binding.1"
                     /locus_tag="paeB"
                     /protein_end="300"
                     /protein_start="238"
                     /score="34.8"
                     /tool="antismash"
                     /translation="GLRELVADLLQEAPSSIAEHDNLITHWGLDSIRIMSLAERWRRSG
                     AEVTFVELAERPTLADW"
     CDS_motif       5773..5889
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0001"
                     /evalue="8.30E-20"
                     /label="C2_starter_024-063"
                     /locus_tag="paeF"
                     /protein_end="39"
                     /protein_start="0"
                     /score="63.3"
                     /tool="antismash"
                     /translation="MFNTGEYIDIRGPVDPERFEAALRQTVAEAETLHLRFGE"
     gene            5773..12882
                     /gene="paeF"
     CDS             5773..12882
                     /NRPS_PKS="Domain: Condensation_Starter (1-272). E-value:
                     8.4e-104. Score: 338.9. Matches aSDomain:
                     nrpspksdomains_paeF_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (436-838). E-value:
                     1.5e-114. Score: 374.6. Matches aSDomain:
                     nrpspksdomains_paeF_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (944-1013). E-value: 5e-25. Score:
                     79.4. Matches aSDomain: nrpspksdomains_paeF_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1026-1327). E-value:
                     1.4e-110. Score: 360.8. Matches aSDomain:
                     nrpspksdomains_paeF_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1497-1913). E-value:
                     5.8e-117. Score: 382.6. Matches aSDomain:
                     nrpspksdomains_paeF_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (2020-2087). E-value: 1.2e-27.
                     Score: 87.8. Matches aSDomain: nrpspksdomains_paeF_PCP.2"
                     /NRPS_PKS="Domain: Thioesterase (2107-2344). E-value:
                     1.4e-38. Score: 125.5. Matches aSDomain:
                     nrpspksdomains_paeF_Thioesterase.1"
                     /codon_start=1
                     /gene="paeF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRP-metallophore: Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     375.8; E-value: 5.9e-114)"
                     /gene_kind="biosynthetic"
                     /product="nonribosomal peptide synthetase NRPS"
                     /protein_id="AEI70245.1"
                     /sec_met_domain="Condensation (E-value: 3.6e-68, bitscore:
                     218.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-128, bitscore:
                     417.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2e-16, bitscore:
                     49.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFNTGEYIDIRGPVDPERFEAALRQTVAEAETLHLRFGEDGEGPW
                     QRLEPSSDWTLHHIDFSGTDHPLEAAEAWMRQNLAEPMDLTRGPLFTQALFKLAPDRFL
                     WYQRIHHLVIDGYSFSLLAQRAAQLYTTFFQEQPPGPGAFGALQSIFQEDEAYRASEQQ
                     ERDRAFWLARFADAPEAVSLGSRTARAGAGFLRRTAQLSPDDASALRDAADRTGTTWPD
                     VVIAAVAAYVHRMTGADDVILGLPMMCRLGSASLRIPGMVMNLLPLRLAVRPEMPLSEL
                     LRQVSREVREARRHQLYRQQDMRRELKLLGENRRLFGPMVNVMPFDYRLSFAGCPGIPH
                     NLSAGPVDDLSIHVYDRSDGCGLRVDFDGNPAVYGAEELAAHQRRFLGWLERLASADPG
                     QPISQIDMLLPEEREQVLIGWNETARELPEASTSAMVEAQAARTPDEVAVVFEDTILTY
                     AELNRRTNRLAHALISQGVGPEGIVALLLPRSAEAVVAVLAVHKTGAAYLPLDPDYPQD
                     RLAFMLQDAAPLCVLTDRETASRLPSGAAGPLLVLDEPATEAQLLHQPETSPGDEDRTG
                     RLSPLHPAYILYTSGSTGKPKGVIVTFGSLTNLLVSMQDKFGLSVRDRLLSVTTIAFDI
                     SVLEMFLPLTTGARIVIAPRPVIMDPPALARMIHESGATIVQATPTLWQALASSKPEPF
                     PGLRIITGGEAFPLGLKLAMQSLGCEVHNQYGPTETTIYSTAGRLGEERTGTPPIGGPI
                     ANTQAYVLDAGLSPVPPGFAGDLYLAGAGLARGYLGRPDLTAERFVADPFGPPGSRMYR
                     TGDLARWLEDGTLDYIGRADHQIKIRGFRVELGEIESLLSRHPAIDQVTVVAREDRPGD
                     KRLVAYFTANSPDVPDPAELRLYVAEEMPDYMVPSAFVPLDVMPLTPNKKIDRKALPAP
                     DFHAVVSRSPRTPQEELLCGLFAEVLGLAKAGIDDDFFALGGHSLLAGRIVARIREVFG
                     VEFGIGGLFESPTVASLAKRLDQAQAARPAVRPAERPEVVPLSFAQNRLWFLYRLEGPS
                     PTYNIPLVARLSGPLDTVALEEALGDVVSRHETLRTIFPDTQGSSQQLILDATEAKPRL
                     LVTEVREDELSERLAEAVRYSFRLAEEPSLRAELFVLGENEYALLLLLHHIAGDGWSLV
                     PLTRELSAAYAARLRGESPAWARLPVQYADYSIWQERLLGSEGDADSLIAQQLAYWTRT
                     LQGLPDELTLPTVRPRPSAASYRGGVIRFRIGSELNLRLAELARESKASLFMVLQSALA
                     ALLTRLGGGTDIPIGSPIAGRSDDALDGLIGLFINTLVLRTDTSGDPSFRELLARVRKA
                     SLAAYEHQDVPFERLVEVLNPVRSRARHPLFQIMLVLQNTPDAALELPGVSARLQLDSP
                     GTSKFDLTFELNERRRPDGTPDGLEGLLEYSSDLFEGSTAERLATRFVQVLEGAAAEPD
                     QPIGRLDILMPDERSSLLEQWREPLPVTPGAHLPVLFEAQAARTPDAAAVVYEDALLDY
                     AELNRRANRLAHLLIAEGVGPEQMVALALPRSVEMVVGVLAVLKAGAAYLPLDPDYPAD
                     RLAYMLEDARPVYVVTSEAGAQGLPDTGSLPRLVLDAPDTAERLRAYSPDNPGDGDRRG
                     PLSPLSPAYMIYTSGSTGKPKGVVIPHQNVIRLFASTQHWFGFGSEDVWTLFHSYAFDF
                     SVWEIWGPLLHGSRLVVVSHTVSRSPAEFLQLLVRERVTVLNQTPSAFYQLMQADREHP
                     SLGGELALRYVVFGGEALELGRLEEWYARHPDDAPRLINMYGITETTVHVSYKELDRSS
                     AASGAGSLIGEAIPDLRVYVLDEALQPVPPGVAGEMYVAGAGLARGYWGRPGLTAERFV
                     ADPFGAPGSRMYRTGDLARRFADGSLDYLGRADHQVKIRGFRIEPGEIEAVLAKHPGVA
                     QVAVVVREDQPGDKRLVAYVVPAPDSLAEPAELRRYAGAGLPDYMVPSAVIGMDALPLT
                     PNGKLDRKALPAPDWTVDPDGRGPRTPQEEVLCDLFAEVLGLRRVGIDDGFFELGGHSL
                     LAVRLMSRIREAMGRDLGIGVLFETPTVAGLAERLEMGTDQSALQVLLPLRAHGTERPL
                     FCVHPAGGLSWCYAGLMKHLGMEHPIYGLQARGIAQSETLPESLDEMTADYIAHIRTVQ
                     PTGPYRLLGWSLGGNVAQAMAVQLQQEGEEVEFLAMLDAFPSHYLPIRGEVDEEEALTA
                     MLALGGYDPDSLGDVPLTMAAAIEILRSDGSALASLDEAIIRNLRTTYENSVRLLGAYV
                     PKRYEGDLLFFHSTIIPDWFDPIDPEMWLPYISGQMERYDIACRHKDLCQPGPLTEIGQ
                     QISVKLQALKSRTAKTFREEIKR"
     aSDomain        5776..6588
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_Condensation_Starter.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="8.40E-104"
                     /label="paeF_Condensation_Starter.1"
                     /locus_tag="paeF"
                     /protein_end="272"
                     /protein_start="1"
                     /score="338.9"
                     /tool="antismash"
                     /translation="FNTGEYIDIRGPVDPERFEAALRQTVAEAETLHLRFGEDGEGPWQ
                     RLEPSSDWTLHHIDFSGTDHPLEAAEAWMRQNLAEPMDLTRGPLFTQALFKLAPDRFLW
                     YQRIHHLVIDGYSFSLLAQRAAQLYTTFFQEQPPGPGAFGALQSIFQEDEAYRASEQQE
                     RDRAFWLARFADAPEAVSLGSRTARAGAGFLRRTAQLSPDDASALRDAADRTGTTWPDV
                     VIAAVAAYVHRMTGADDVILGLPMMCRLGSASLRIPGMVMNLLPLRLAV"
     aSModule        5776..8811
                     /complete
                     /domains="nrpspksdomains_paeF_Condensation_Starter.1"
                     /domains="nrpspksdomains_paeF_AMP-binding.1"
                     /domains="nrpspksdomains_paeF_PCP.1"
                     /locus_tags="paeF"
                     /monomer_pairings="Ala -> Ala"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6097..6162
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0002"
                     /evalue="8.40E-10"
                     /label="C3_starter_134-155"
                     /locus_tag="paeF"
                     /protein_end="130"
                     /protein_start="108"
                     /score="31.4"
                     /tool="antismash"
                     /translation="IHHLVIDGYSFSLLAQRAAQLY"
     CDS_motif       6490..6579
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0003"
                     /evalue="6.40E-14"
                     /label="C5_starter_265-294"
                     /locus_tag="paeF"
                     /protein_end="269"
                     /protein_start="239"
                     /score="44.1"
                     /tool="antismash"
                     /translation="DVILGLPMMCRLGSASLRIPGMVMNLLPLR"
     CDS_motif       6628..6741
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0004"
                     /evalue="1.90E-15"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="paeF"
                     /protein_end="323"
                     /protein_start="285"
                     /score="49.3"
                     /tool="antismash"
                     /translation="SREVREARRHQLYRQQDMRRELKLLGENRRLFGPMVNV"
     aSDomain        7081..8286
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_AMP-binding.1"
                     /evalue="1.50E-114"
                     /label="paeF_AMP-binding.1"
                     /locus_tag="paeF"
                     /protein_end="838"
                     /protein_start="436"
                     /score="374.6"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="EAQAARTPDEVAVVFEDTILTYAELNRRTNRLAHALISQGVGPEG
                     IVALLLPRSAEAVVAVLAVHKTGAAYLPLDPDYPQDRLAFMLQDAAPLCVLTDRETASR
                     LPSGAAGPLLVLDEPATEAQLLHQPETSPGDEDRTGRLSPLHPAYILYTSGSTGKPKGV
                     IVTFGSLTNLLVSMQDKFGLSVRDRLLSVTTIAFDISVLEMFLPLTTGARIVIAPRPVI
                     MDPPALARMIHESGATIVQATPTLWQALASSKPEPFPGLRIITGGEAFPLGLKLAMQSL
                     GCEVHNQYGPTETTIYSTAGRLGEERTGTPPIGGPIANTQAYVLDAGLSPVPPGFAGDL
                     YLAGAGLARGYLGRPDLTAERFVADPFGPPGSRMYRTGDLARWLEDGTLDYIGRADHQI
                     KIR"
     CDS_motif       7264..7305
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0005"
                     /evalue="3.30E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="paeF"
                     /protein_end="511"
                     /protein_start="497"
                     /score="14.1"
                     /tool="antismash"
                     /translation="LAVHKTGAAYLPLD"
     CDS_motif       7522..7578
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0006"
                     /evalue="7.10E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="paeF"
                     /protein_end="602"
                     /protein_start="583"
                     /score="27.8"
                     /tool="antismash"
                     /translation="AYILYTSGSTGKPKGVIVT"
     CDS_motif       7942..7968
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0007"
                     /evalue="4.70E-02"
                     /label="NRPS-A_a5"
                     /locus_tag="paeF"
                     /protein_end="732"
                     /protein_start="723"
                     /score="6.9"
                     /tool="antismash"
                     /translation="QYGPTETTI"
     CDS_motif       8077..8166
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0008"
                     /evalue="5.10E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="paeF"
                     /protein_end="798"
                     /protein_start="768"
                     /score="47.6"
                     /tool="antismash"
                     /translation="PPGFAGDLYLAGAGLARGYLGRPDLTAERF"
     CDS_motif       8251..8316
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0009"
                     /evalue="5.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="paeF"
                     /protein_end="848"
                     /protein_start="826"
                     /score="37.7"
                     /tool="antismash"
                     /translation="YIGRADHQIKIRGFRVELGEIE"
     CDS_motif       8353..8406
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0010"
                     /evalue="1.30E+01"
                     /label="C5_LCL_267-296"
                     /locus_tag="paeF"
                     /protein_end="878"
                     /protein_start="860"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="TVVAREDRPGDKRLVAYF"
     CDS_motif       8533..8556
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0011"
                     /evalue="1.10E+00"
                     /label="NRPS-A_a10"
                     /locus_tag="paeF"
                     /protein_end="928"
                     /protein_start="920"
                     /score="2.9"
                     /tool="antismash"
                     /translation="KIDRKALP"
     aSDomain        8605..8811
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_PCP.1"
                     /evalue="5.00E-25"
                     /label="paeF_PCP.1"
                     /locus_tag="paeF"
                     /protein_end="1013"
                     /protein_start="944"
                     /score="79.4"
                     /tool="antismash"
                     /translation="EELLCGLFAEVLGLAKAGIDDDFFALGGHSLLAGRIVARIREVFG
                     VEFGIGGLFESPTVASLAKRLDQA"
     aSDomain        8851..9753
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.40E-110"
                     /label="paeF_Condensation_LCL.1"
                     /locus_tag="paeF"
                     /protein_end="1327"
                     /protein_start="1026"
                     /score="360.8"
                     /tool="antismash"
                     /translation="EVVPLSFAQNRLWFLYRLEGPSPTYNIPLVARLSGPLDTVALEEA
                     LGDVVSRHETLRTIFPDTQGSSQQLILDATEAKPRLLVTEVREDELSERLAEAVRYSFR
                     LAEEPSLRAELFVLGENEYALLLLLHHIAGDGWSLVPLTRELSAAYAARLRGESPAWAR
                     LPVQYADYSIWQERLLGSEGDADSLIAQQLAYWTRTLQGLPDELTLPTVRPRPSAASYR
                     GGVIRFRIGSELNLRLAELARESKASLFMVLQSALAALLTRLGGGTDIPIGSPIAGRSD
                     DALDGLIGLFINTLVLRTDT"
     aSModule        8851..12804
                     /complete
                     /domains="nrpspksdomains_paeF_Condensation_LCL.1"
                     /domains="nrpspksdomains_paeF_AMP-binding.2"
                     /domains="nrpspksdomains_paeF_PCP.2"
                     /domains="nrpspksdomains_paeF_Thioesterase.1"
                     /final_module
                     /locus_tags="paeF"
                     /monomer_pairings="Thr -> Thr"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8917..9033
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0012"
                     /evalue="4.60E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="paeF"
                     /protein_end="1087"
                     /protein_start="1048"
                     /score="54.4"
                     /tool="antismash"
                     /translation="PTYNIPLVARLSGPLDTVALEEALGDVVSRHETLRTIFP"
     CDS_motif       9235..9300
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0013"
                     /evalue="3.90E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="paeF"
                     /protein_end="1176"
                     /protein_start="1154"
                     /score="32.2"
                     /tool="antismash"
                     /translation="LHHIAGDGWSLVPLTRELSAAY"
     CDS_motif       9349..9387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0014"
                     /evalue="1.40E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="paeF"
                     /protein_end="1205"
                     /protein_start="1192"
                     /score="14.5"
                     /tool="antismash"
                     /translation="QYADYSIWQERLL"
     CDS_motif       9655..9744
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0015"
                     /evalue="9.80E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="paeF"
                     /protein_end="1324"
                     /protein_start="1294"
                     /score="43.7"
                     /tool="antismash"
                     /translation="DIPIGSPIAGRSDDALDGLIGLFINTLVLR"
     CDS_motif       9793..9912
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0016"
                     /evalue="1.50E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="paeF"
                     /protein_end="1380"
                     /protein_start="1340"
                     /score="68.8"
                     /tool="antismash"
                     /translation="RKASLAAYEHQDVPFERLVEVLNPVRSRARHPLFQIMLVL"
     aSDomain        10264..11511
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_AMP-binding.2"
                     /evalue="5.80E-117"
                     /label="paeF_AMP-binding.2"
                     /locus_tag="paeF"
                     /protein_end="1913"
                     /protein_start="1497"
                     /score="382.6"
                     /specificity="substrate consensus: Thr"
                     /tool="antismash"
                     /translation="FEAQAARTPDAAAVVYEDALLDYAELNRRANRLAHLLIAEGVGPE
                     QMVALALPRSVEMVVGVLAVLKAGAAYLPLDPDYPADRLAYMLEDARPVYVVTSEAGAQ
                     GLPDTGSLPRLVLDAPDTAERLRAYSPDNPGDGDRRGPLSPLSPAYMIYTSGSTGKPKG
                     VVIPHQNVIRLFASTQHWFGFGSEDVWTLFHSYAFDFSVWEIWGPLLHGSRLVVVSHTV
                     SRSPAEFLQLLVRERVTVLNQTPSAFYQLMQADREHPSLGGELALRYVVFGGEALELGR
                     LEEWYARHPDDAPRLINMYGITETTVHVSYKELDRSSAASGAGSLIGEAIPDLRVYVLD
                     EALQPVPPGVAGEMYVAGAGLARGYWGRPGLTAERFVADPFGAPGSRMYRTGDLARRFA
                     DGSLDYLGRADHQVKIR"
     CDS_motif       10450..10491
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0017"
                     /evalue="1.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="paeF"
                     /protein_end="1573"
                     /protein_start="1559"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LAVLKAGAAYLPLD"
     CDS_motif       10708..10767
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0018"
                     /evalue="4.60E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="paeF"
                     /protein_end="1665"
                     /protein_start="1645"
                     /score="31.4"
                     /tool="antismash"
                     /translation="AYMIYTSGSTGKPKGVVIPH"
     CDS_motif       11161..11184
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0019"
                     /evalue="2.20E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="paeF"
                     /protein_end="1804"
                     /protein_start="1796"
                     /score="2.1"
                     /tool="antismash"
                     /translation="YGITETTV"
     CDS_motif       11302..11391
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0020"
                     /evalue="1.40E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="paeF"
                     /protein_end="1873"
                     /protein_start="1843"
                     /score="52.5"
                     /tool="antismash"
                     /translation="PPGVAGEMYVAGAGLARGYWGRPGLTAERF"
     CDS_motif       11476..11541
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0021"
                     /evalue="8.50E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="paeF"
                     /protein_end="1923"
                     /protein_start="1901"
                     /score="40.1"
                     /tool="antismash"
                     /translation="YLGRADHQVKIRGFRIEPGEIE"
     CDS_motif       11755..11781
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0022"
                     /evalue="2.00E-01"
                     /label="NRPS-A_a10"
                     /locus_tag="paeF"
                     /protein_end="2003"
                     /protein_start="1994"
                     /score="4.9"
                     /tool="antismash"
                     /translation="GKLDRKALP"
     aSDomain        11833..12033
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_PCP.2"
                     /evalue="1.20E-27"
                     /label="paeF_PCP.2"
                     /locus_tag="paeF"
                     /protein_end="2087"
                     /protein_start="2020"
                     /score="87.8"
                     /tool="antismash"
                     /translation="EEVLCDLFAEVLGLRRVGIDDGFFELGGHSLLAVRLMSRIREAMG
                     RDLGIGVLFETPTVAGLAERLE"
     aSDomain        12094..12804
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_paeF_Thioesterase.1"
                     /evalue="1.40E-38"
                     /label="paeF_Thioesterase.1"
                     /locus_tag="paeF"
                     /protein_end="2344"
                     /protein_start="2107"
                     /score="125.5"
                     /tool="antismash"
                     /translation="RPLFCVHPAGGLSWCYAGLMKHLGMEHPIYGLQARGIAQSETLPE
                     SLDEMTADYIAHIRTVQPTGPYRLLGWSLGGNVAQAMAVQLQQEGEEVEFLAMLDAFPS
                     HYLPIRGEVDEEEALTAMLALGGYDPDSLGDVPLTMAAAIEILRSDGSALASLDEAIIR
                     NLRTTYENSVRLLGAYVPKRYEGDLLFFHSTIIPDWFDPIDPEMWLPYISGQMERYDIA
                     CRHKDLCQPGPLTEI"
     CDS_motif       12097..12126
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0023"
                     /evalue="1.40E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="paeF"
                     /protein_end="2118"
                     /protein_start="2108"
                     /score="11.6"
                     /tool="antismash"
                     /translation="PLFCVHPAGG"
     CDS_motif       12277..12351
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_paeF_0024"
                     /evalue="1.60E-14"
                     /label="NRPS-te1"
                     /locus_tag="paeF"
                     /protein_end="2193"
                     /protein_start="2168"
                     /score="46.1"
                     /tool="antismash"
                     /translation="QPTGPYRLLGWSLGGNVAQAMAVQL"
ORIGIN
        1 atgaacggaa gcgtggcggt tcagagcgta agcattgaag gagatggaag catagtggcg
       61 ttcaagccga acgaacaaag cgaagtaacg ctgaaagacc tcgcgcgcgg caaagtcgat
      121 attccgtggg cggagcagtg gatcatgaaa tcgcgtgatc atcaccggag gtaccagatc
      181 ctcgtggcga ggcctccgga ggccccgcct cctgccggat ttccggtcat ttatttgctg
      241 gatgcgaatt cggtattcgg cacgatggtg gaagccgtgc ggctgcagag ccggcggccc
      301 gacaaaaccg ggatcgtccc ggcggttatc gtcgggatcg ggtatcctgt ggacggaccg
      361 ttcgcgccgg agcggtttta cgatctgacg ccggcggcta cgaaggaata tttgaatcga
      421 gcggacagca cgccgcttcc cgagcaaggc ggcgccgctc attttctaaa attcatcgag
      481 gaggaattaa agccgcagat cgaagacgag tttccagtgg accgcagcag acagacgatt
      541 ttcggacatt cgctcggcgg gctatttgtg ctgtacgcgc tgtttgcgaa gccgcatgcg
      601 tttcaaagct atatcgcggg cagcccgtcg ctgcactgga acgagtcgtt cctgcttgag
      661 gcggagcggg aatttgcgaa aggatggcag cctgaggcca atcggatcga gctgctgctc
      721 ggcgttggtg agatggagaa gacgcatgtc tcgcgcaatt gcgatcgtgc gctggcgctc
      781 tcggaacggc tggcggcctt gtccgggcgc ggattggacg tggaatataa ggagtttgaa
      841 ggcgaggggc acgtctcggt actgcccgtg ctgatcagcc gggctttgcg gctggcgctt
      901 cggccgaagc cgtgacgtcg gccgagctac agatacaggg gaagcaagga catcgagatt
      961 aggggaaagg acggagatga agtggtggag cttggaatca aaggaaaagt cgcgctcgtc
     1021 accggagcgg cccaaggcat aggggaagcc gtagcacgtg cattggctga gctcggggct
     1081 tccgtggccg ccttagaccg caatgcggac gggcttggca gccttgtagc ggagcttaat
     1141 gcccggggcc atcagactgc ggcttatccg gcggacgtca gcgacagctc ggccgtagag
     1201 gacgcggtgg agcgcatcga gcgggagctt gggcccatcg gcattctcgt caatgtcgcc
     1261 ggggtgctcc ggatgggggc gatcgaatcg tacagcgacg aggactggga ggcgacattt
     1321 gccgtcaaca cgaagggcgt gttttacgta tcccgtgccg tcgttcgacg catggctctc
     1381 cgccgatccg gggcgatcgt gaccgtaggg tcgaatgcct ccggggtacc gcgcatgcat
     1441 atggcggctt atgcggcctc caaggcggcg tcgacggtgt tcaccaaatg tctggggctg
     1501 gagcacgctc ggcacaatat ccgctgcaat atcgtttcgc cgggctcgac cgatacggcg
     1561 atgcagcgtc tgctatgggc ggatcagtcg ggggagcagg cggtcatcgc gggttcggcg
     1621 gagtcgttcc ggctgggcat tccgctcgga aagctggcca gaccgtccga tattgcggat
     1681 gcggtcgttt ttctcgtgtc cgaccgggcg ggtcatatta cgatgagcga tttgtgcatc
     1741 gatggcggtg ccacgctggg aaaataaatt cattctaaaa gaggggaatg atggacatgg
     1801 tgaatctgga agcggttcct gccgcatggg cttctgaact gatcgatatg tacgaagccg
     1861 gctcgtcgtt tttcctggcc tcgccgcagc gtacgctgct ggcgaaaggg gaggcggcca
     1921 ggctgtccgt gcagggaggc gcggatcggc tcaaaagctt gccgcagcgc gtggccgagc
     1981 tgctggcccg cacgcaattt tccggagggg cgccttccgt tgtcgtggga gcgatcccct
     2041 tcgatcccgc gaagcctgcg gagctgatcg taccgcagac cgcccggtgg gccggcaagc
     2101 tacagcttag cagcgaggct gcggaaaggc aggccgacgc ctcggactat aagctgcgcc
     2161 ccgtgccgga gccggaagtc tacgagcata gcgtgagccg ggcgttggcg cgttttcaga
     2221 agggggacct ccgcaaggtc gttctcggga gaaccttgca tctgacgctg ccgacgaagg
     2281 ttgatgtcaa ccggcttctc cgcaatctgg cccggcataa tccgcacggt tatacgttcg
     2341 cggtaaacct ggccccggga gaagcccggg ccgcatggac cccggacaag tcgaacggtc
     2401 aggagccgcg aacgctgatc ggcgccagcc cggagctgct tgtgacgaga acgggagggc
     2461 ggctgaaggc gaatccgctc gcgggctccg cgccccgcag cagcgatccg gtcgaggatc
     2521 ggcggagggc ggaggcgctg ctcgcctcgg cgaaggaccg gcatgagcat gcggttgtga
     2581 tcgaagccgt cgccgacgcg ctgcgcccct attgcacccg cttggacgta ccgcgcgagc
     2641 cttcgctcgt acagacgtcc acgatgtggc atctgtccac ggtcgttacc ggagaactgg
     2701 ccgatccatg ggcatcgtcg ctggagctgg ctttggcgct gcacccgaca ccggcgattt
     2761 gcgggacacc gaccgatttg gcgcaggaaa cgattcgcga gagcgagccg ttcgaccggg
     2821 gctttttcac gggaacggtc ggctggtgcg atgcgagcgg cgacggggaa tgggtcgtga
     2881 cgattcgctg cgccgaggtg gaagggcgcg agctgcggct gttcgcgggc gcggggatcg
     2941 tcgagggatc gagcccgcag gccgagctgg cggaaacgtc cgccaaattc cggacgctgc
     3001 tgcaggcgat gggtctcaat cagccgcagc tggcagtcgt aaagggggat aaatgatgcg
     3061 ttcgcaatat ccttcatggc cgaaagagct ggcggatttt taccgggaga ccggctgctg
     3121 gcagggcgag acgttcggcg aaatgctgcg cgggcgcgcc gccgcctacg gggaccgcat
     3181 cgcggtcgtc agcggaacga gccggatcag ctacgccgag ctggatgcga gagtcgaccg
     3241 gttggccgcc ggattttaca agcttgggat tcggcaggac gacaaggtga ttttgcagct
     3301 tccgaatatc gcggagttta tcgaggtgtg ttttgcgctg tttcggctgg gcgcgctgcc
     3361 ggtattcgct cttccgcttc atcgcagaag tgagatcgtt tatttttccg agtttacaaa
     3421 tgcgaatgct tatattattc cggatgtcga agcgggcttc gattaccggg agctggcggc
     3481 gcaagtacag gagcaggtac cgacgctgcg ccatgtcatc gtagcgggcg atcccgggaa
     3541 gtttacggcg ctgcgcgacc tgtacgccga tccgctgccc gatttgccgg ggccaagctc
     3601 cgacgacgtg gcgtttcttc agctgtcggg cggcagcacg gggctgccga agctgattcc
     3661 gcgcacgcac gacgattata tctacagctt gcggatgagc gccgaagtgt gcgcactcga
     3721 cgagcagagt atctatcttg ccgtgctccc tgcggcccac aactatccgc tgagctctcc
     3781 gggcgtgctg ggcacgctct acgcgggcgg acgcgtcgtg ctgtcccgcg gctctagccc
     3841 ggacgaggcg ttccctctca tcgagcggga acgcgtcacg atcaccgccg tcgtgcctcc
     3901 gctggctctc gtctggctgg acgccgccga gtcgcgccgc agcgaccttt cgtcgcttcg
     3961 gctgctgcag gtcggcgggg ccaagttcag cgcggaggcc gcccgtaagg tcaagccgat
     4021 gctaggctgc actttgcagc aggtgttcgg gatggcggaa gggctggtca actatacccg
     4081 gccggacgat cccgaggaga ttgtggtgaa tacgcagggc agaccgatgt cgccttatga
     4141 cgagatccgc atcgtggatg acgaggatga agaggtcgct cccggtcagg tcggacatct
     4201 gctgacgcgc ggtccctata cgatccgcgg ctattataaa gccgaagagc acaacgccag
     4261 agcgttcacg gcggacggct tttaccgcac gggggatatg gccagaatga cgcccgaggg
     4321 ctatcttgtc gtcgagggcc gggccaagga ccagatcaac cgcggcgggg ataaggtggc
     4381 ggcggaggag gtcgagaacc atcttctcgc gcatccgggc gtgcatgatg ccgccgtcgt
     4441 ttcgatgccc gacgcttacc ttggcgagcg cagctgcgcc tttatcgtcc cgtattcacc
     4501 ggcgcctact ccggccgagc tcaaagcgtt ccttagggag cgggggctgg ctgcttacaa
     4561 aattccggac cgggtggaat ttatggagtc gttcccccga accggggtcg gcaagatcag
     4621 caaaaaggca ctgcgcgaac tgatagaaca gaagcagcag gctctagctg cgcctccgat
     4681 aaaataacgt gagaaaagag gagatacgat ggctcttcct gccataacgc cttatccgat
     4741 gccgacggcg tccgacctgc ccgccaaccg ggtgaattgg atacccgatc cgaaacgtgc
     4801 ggttttgctg attcatgaca tgcagcagta tttcgtggat gctttcacgg aaggggcatc
     4861 ccctgtgatc gagctgctgg agaacatccg cacgctccga aacgcttgcg acgagctggg
     4921 cataccggtc gtctattccg cccagccggg cggacaaacg ctggagcagc gcggattgct
     4981 gcaggatttc tggggtcccg ggatcaatga cgggccatat cagaagcaaa tcatcaagga
     5041 gctgccgccg ggcgagcgcg atatcgtgtt gaccaaatgg cggtacagcg cctttcagaa
     5101 gaccgatttc cgcgccagac tgacccagct tggccgcgac caattgatcg tatgcggcat
     5161 ttacgctcac atcggctgcc ttatgacttc ttgcgaagcg tttatgcagg aagtggagcc
     5221 tttcttcgtc gccgatgcgg tggcggactt ttcgctggag aagcaccggc tggcgatcac
     5281 ctacgcggcc gaacgctgcg cggttgtcat gacaacggag cgtttgatca aggcgctccg
     5341 cggtgaagcg ggagcctcag ccgagccgga agccgcatcg gaagcggccc cggcggcgga
     5401 aagcgggtcg ctgaccaagg acggcttgcg ggagctggtg gcggacttgc tgcaggaagc
     5461 tccgtcgtcc attgcagagc atgataactt gattacgcat tgggggctgg attcgatccg
     5521 catcatgagt ttggccgaac ggtggcggcg ctccggggcg gaagtcactt tcgtggagct
     5581 ggcggagcgt ccgacgctgg ccgattggtt cgctctgctg tccgcccgcc tgagcaggac
     5641 tttgccgaac ggagattaca taacgacatg aaggagggag cgctaatgtc cgatgctcgg
     5701 caggcccgcc gaccgttgac gggggcgcag ctggggattt ggttcgccca gcagcttgac
     5761 ccggagagtc caatgttcaa tacgggggaa tatatcgata ttcgcggacc tgtagacccg
     5821 gagcgtttcg aagcggcgct ccgtcaaacc gtggcggagg cggaaacgct gcatctgcgc
     5881 ttcggcgaag acggtgaggg gccttggcag cgtcttgagc catcgtccga ctggacgctg
     5941 catcatatcg acttcagcgg aacggaccac ccgctggaag cggcggaggc ttggatgaga
     6001 cagaacttgg ccgagccgat ggacctgacg cgcggaccgc tgtttacaca ggcgttgttc
     6061 aagctggccc cggaccggtt tctctggtat cagcgcatcc atcacctcgt catcgacggc
     6121 tacagctttt ctttgctggc ccaaagagct gctcagctct ataccacctt cttccaggag
     6181 cagccgcccg ggccgggagc gttcggcgcg ctgcaatcga ttttccaaga ggacgaagct
     6241 tatcgcgctt cggagcagca agagcgggac cgggccttct ggcttgcccg cttcgccgat
     6301 gcgccggaag cggtaagtct gggcagccgg acggccagag ccggggcggg ctttctacgc
     6361 cggaccgcgc agctatcgcc ggacgatgcg tccgcgctgc gggacgcggc cgaccggacg
     6421 ggaacgacgt ggcccgatgt cgtgattgcg gcggtggcgg cttatgtgca tcggatgacc
     6481 ggggccgacg acgtgattct cggtctgccc atgatgtgcc gtctgggctc cgcttcgctg
     6541 cgcattccgg gcatggtcat gaacctgctg ccgctgcgtt tggccgtgcg gcccgagatg
     6601 ccgttgtccg agctgctgcg ccaagtctca cgggaggttc gcgaggcccg gcgccatcag
     6661 ctgtaccggc agcaggatat gcggcgtgag ttgaagctgc tcggggaaaa ccgccgcttg
     6721 ttcgggccga tggtcaacgt gatgccgttc gactatcggc tgagctttgc cggctgcccc
     6781 ggcattccgc ataatctgtc ggccgggcct gtggacgatc tgtcgatcca cgtctatgac
     6841 cggtcggacg gatgcggact gcgggtagac ttcgacggaa atccggcggt gtacggggcg
     6901 gaagagctgg cggcccatca gcggaggttc cttggctggc tggagcggct tgcctcggcc
     6961 gatcccgggc agccgatctc gcagatcgac atgctgctgc ccgaggaacg ggaacaggtg
     7021 ctcatcggat ggaacgaaac ggcccgtgaa ttgccggaag cttccacgtc cgcgatggtc
     7081 gaggcccaag cggcccgtac gccggatgag gttgccgtcg tattcgagga cacgatcctc
     7141 acgtacgccg aattgaaccg gcgcaccaac cggctggctc atgcgttaat ctcgcagggc
     7201 gtcggtccgg aaggcatcgt ggcgctgctg ctgccgcggt cggcggaagc ggtcgtggcg
     7261 gtgctggccg tccataaaac cggcgccgcc tatttgccgc tggaccccga ctacccgcag
     7321 gatcggttgg ccttcatgct ccaagacgcc gcccccctgt gcgtcctgac ggacagggaa
     7381 acggcttccc ggctaccttc cggagcagcg gggccacttc tggtgcttga cgagcctgcc
     7441 accgaagcgc agctgctgca ccagccggaa acttctcccg gcgacgagga ccgtaccggc
     7501 cgtctgtcgc ctcttcatcc tgcctatatt ctttacacgt cgggctcaac cggcaagccg
     7561 aagggcgtga tcgtgacctt cggcagcttg accaacctgc tcgtgtccat gcaggacaaa
     7621 ttcgggctga gcgtccggga ccggctgctg tcggtgacga cgattgcttt tgacatctcg
     7681 gtactggaaa tgttcctgcc tcttacgaca ggagcccgca tcgttatcgc tccgaggccg
     7741 gtgatcatgg acccgcctgc gctggcaagg atgattcacg agtcgggggc tacgatcgtg
     7801 caggcgacgc cgactctgtg gcaggcgctt gcgtcgagca agcccgagcc gttccccggc
     7861 ctgcggatca ttacgggcgg cgaggcgttt ccgctgggac tgaagctcgc gatgcagtcg
     7921 ctcggctgcg aggtgcataa ccaatacggg ccgacggaaa cgacgatcta ttccactgcc
     7981 gggcgtctgg gcgaagagcg cacggggacg ccgccgatcg gcgggccgat tgcgaacacg
     8041 caggcctatg tgcttgatgc ggggctgtct ccggtaccgc cgggcttcgc gggcgatctg
     8101 tatcttgcgg gggcgggact ggcccgcggc tatttgggcc ggccggactt gacggccgag
     8161 cgcttcgtag ccgacccgtt cggaccgccc ggcagccgga tgtaccgtac gggcgacctt
     8221 gcgagatggc ttgaggacgg gaccctcgat tacatcggac gcgccgatca tcagatcaag
     8281 attcgcggct tccgggtgga gctcggcgaa atcgagtcgc tgctctcgcg gcatccggcc
     8341 atcgatcaag ttacggtcgt cgcgcgggag gatcggcccg gggataaacg gctagtcgct
     8401 tatttcacag ccaattcacc ggacgttccc gatccggcgg agcttcgact gtacgtggcc
     8461 gaagagatgc ccgattacat ggtaccctca gccttcgtgc cgttggacgt catgcccctg
     8521 acgcccaata aaaaaatcga ccgcaaggcg ctgccggccc cggatttcca cgcggtcgtc
     8581 agccgcagtc cgagaacgcc gcaggaggag ctgctgtgcg gcttgttcgc ggaggtactc
     8641 ggcctggcga aggcgggcat cgacgacgac ttcttcgcgc tcggcggtca ttccctgctg
     8701 gcggggcgga tcgtggcccg tatccgagaa gtgttcggcg tggaattcgg tatcgggggc
     8761 ctcttcgagt cgcctaccgt ggccagtctc gccaagcggc tcgatcaggc gcaagccgcc
     8821 agaccggccg tgcgtccggc tgagcggccg gaggtggtcc cgctttcctt tgctcagaac
     8881 cggctgtggt ttctgtatcg tctggaaggt ccgagtccga cctacaatat tccgttggtt
     8941 gcccggttat caggcccgtt ggacacggtc gcgctggaag aagcgctcgg cgatgtggta
     9001 agccggcatg agacgctgcg cacgattttc ccggatacgc aaggctcctc gcagcagctc
     9061 attctggatg cgacggaagc caagccccgg ctgctggtga ccgaagtccg cgaagacgag
     9121 ctatccgagc ggctggcgga ggcggtgcgt tacagcttcc ggctcgccga ggagccttcg
     9181 cttcgcgccg aattgttcgt gcttggcgag aacgaatacg ccctgctgct gctgctgcac
     9241 catatcgcgg gcgacggctg gtcgctggtg ccgctcaccc gcgagctgtc cgccgcctac
     9301 gccgcccgtc tgcggggaga atcgccggct tgggcccggc tgccagtgca atatgccgac
     9361 tattcgatct ggcaggaacg gctgcttggc agtgagggcg atgctgacag cttgattgcg
     9421 cagcagctcg cctactggac ccggacgctg cagggcttgc cggacgagct gacgctgccg
     9481 accgtccgtc cgaggccttc ggccgcaagc tatcggggcg gagttatccg cttccgaatc
     9541 ggcagcgagc tgaacctccg gcttgcggag cttgcccgcg aaagcaaggc cagcttgttt
     9601 atggtgctgc agtccgcgct ggcggcgctg cttactcggc ttggcggcgg gacggatatc
     9661 ccgatcggca gtccgattgc gggacggagc gacgacgcgc tggacggcct gatcggcttg
     9721 ttcatcaata cgctggtgct tcgtaccgat acgtccggcg atccgtcctt ccgcgagctg
     9781 ctagcccgcg tccggaaggc aagtctggcc gcatacgagc atcaggatgt gcctttcgaa
     9841 cgtttggtcg aggtgctgaa tcccgtacgt tcgcgggccc gacatccgct gttccagatt
     9901 atgctggtac tgcaaaatac gccggatgcc gcgctggagc tgcccggagt gtcggcacgt
     9961 ctccaattgg acagcccggg cacgtctaag ttcgatctga ccttcgagct gaacgagcgc
    10021 cgcaggccgg atggcacgcc agacgggctg gaggggcttc tggagtacag ctccgacctg
    10081 ttcgagggca gcacggcgga aaggctggcc acacggtttg tacaggtgct cgaaggagcg
    10141 gcggccgagc cggatcagcc gatcgggcgg ctggacatct tgatgcctga cgagcgcagc
    10201 agcctgctgg agcaatggcg cgagccgctg cccgtgacgc cgggggcgca tctgcccgtg
    10261 ctgttcgagg cgcaggcggc ccgtactccc gatgcggcgg cggtcgttta cgaggatgcg
    10321 ctactcgact atgccgagct gaaccgccgt gccaaccggc tggcgcatct gctgatcgcc
    10381 gaaggcgtcg gccccgagca gatggtggcg ttagcgctgc cgcgttcggt agagatggta
    10441 gtcggcgtgc tggccgtgct gaaggccggg gctgcatact tgccgctgga cccggattac
    10501 cctgccgacc ggctggctta tatgctggag gacgccagac cggtgtatgt cgtcacaagc
    10561 gaagccgggg cccagggctt gccggatacc ggcagcctgc cgcgtctggt gctggatgcg
    10621 ccggatacgg cggaaaggct aagggcgtat tcgccggata accccggcga cggcgatcgc
    10681 agagggccgc tgtcgccgct cagccccgcg tatatgatct atacctcggg ctcgacgggc
    10741 aagccgaagg gtgtcgtaat tccgcatcag aacgtcatac ggttatttgc ctcgacgcag
    10801 cattggttcg gcttcggttc agaggatgtc tggacgctgt tccattcgta tgctttcgat
    10861 ttttccgtat gggaaatctg gggaccgctt ctccatggca gccgcctcgt ggtggtatcg
    10921 catacggtca gccgctcgcc cgcggagttc ctgcaattgc tcgtacggga gcgggtgacg
    10981 gtgctgaatc agacgccgtc ggcattttat cagctgatgc aggcggaccg tgagcatccg
    11041 tcgctgggcg gggagctggc tctgcgctac gtcgtcttcg gcggcgaggc gctggagctc
    11101 ggacggctgg aggaatggta tgcgcgccat ccggacgacg ccccgagatt gatcaacatg
    11161 tacggcatta ccgagacaac cgtgcatgtc agctacaagg agctggaccg cagcagcgcc
    11221 gcttcggggg ccggcagcct gatcggcgaa gcgattccgg atttgcgggt ctacgttctg
    11281 gatgaggcgc tgcagcccgt accgcccggg gttgcggggg aaatgtatgt cgccggcgcc
    11341 gggctggcgc gtggctattg gggacgtccg ggtctaacgg cggagcgctt cgtggccgat
    11401 ccgttcggcg cgccgggctc ccggatgtac cgtaccggcg atttggcccg gcgcttcgcc
    11461 gacggctcgc tggattattt gggccgggcg gatcatcagg tgaagatccg cgggttccgc
    11521 atcgagccgg gcgagatcga ggcggttctg gcaaagcatc ccggcgtcgc tcaggtcgcg
    11581 gtcgtggtgc gcgaggatca gccgggcgac aagcggctag tcgcttatgt cgtccccgcg
    11641 ccggactcgc tcgccgagcc tgccgagctg cgccggtatg cgggcgccgg cctgccggat
    11701 tacatggtgc cgtcggccgt catcggcatg gacgccctgc cgcttacgcc gaacggcaag
    11761 ctggaccgga aggcgctgcc tgcgccggat tggaccgtcg accccgatgg aagaggcccg
    11821 cgcacgccgc aagaagaggt gctgtgcgat ttgttcgccg aagtgctcgg gctgcggcgc
    11881 gtggggatcg acgacggctt tttcgagctc ggggggcatt cgctgctggc ggtgcggctg
    11941 atgagccgca ttcgcgaagc gatgggccgc gatctcggca tcggcgtcct cttcgagacg
    12001 ccgacggtgg ctgggcttgc ggagcggctg gagatgggga cggatcaatc cgcgctccaa
    12061 gtgctcctgc cgctgcgggc ccatggtacc gaacggccgc tcttctgcgt gcatccggcg
    12121 ggcgggctta gctggtgcta cgccggtctg atgaagcatc tcgggatgga acacccgatc
    12181 tacggccttc aggcccgggg cattgcgcag agcgagacgc tgccggagtc gctggacgag
    12241 atgacggcgg attacattgc gcacatccgc acagtgcagc caaccggccc gtatcggctg
    12301 ctcggctggt cgctcggcgg caacgtggcg caggccatgg ccgttcagct gcagcaggaa
    12361 ggggaggaag tcgagttcct tgcgatgctg gacgccttcc caagccatta tttgccgatt
    12421 cgcggcgagg tggacgagga agaagcgctg accgcgatgc tggcgctcgg cggctacgac
    12481 ccggacagtc tgggcgacgt tccgcttact atggccgccg ccattgagat tctgcgcagc
    12541 gacggcagcg ccctggcaag cttggacgaa gcaattatcc ggaatctgcg cacgacctac
    12601 gaaaattcgg tccgtttgtt aggggcctac gtgccgaagc ggtacgaggg cgatctgctg
    12661 ttcttccatt ccacgattat tccggactgg ttcgatccga tcgatcccga gatgtggctt
    12721 ccgtatatta gcgggcagat ggagcgctac gatattgcgt gccggcataa agacctgtgc
    12781 cagcccggac cgctgacgga aatcggacag cagatctcgg tgaagctgca ggcgctgaaa
    12841 agccggacag ccaaaacctt cagggaggaa atcaaacgat ga
//
