BGC0000404: penicillin biosynthetic gene cluster from Penicillium chrysogenum
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Location: 1 - 56,820 nt. (total: 56,820 nt).
This entry is originally from NCBI GenBank DQ192518.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000404
Short description penicillin biosynthetic gene cluster from Penicillium chrysogenum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
DQ192518.1
via
Compounds
  • penicillin
Species Penicillium chrysogenum [taxonomy]
References
Chemical products information
penicillin Evidence:
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C16H17N2Na1O4S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABA70575.1
 1969 - 2847 (-) hypothetical protein
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    • ABA70576.1
    		 3499 - 4725 (-) hypothetical protein
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      • ABA70577.1
      		 5170 - 6387 (+) hypothetical protein
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        • ABA70578.1
        		 7551 - 9902 (+) hypothetical protein
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          • ABA70579.1
          		 12451 - 13338 (+) hypothetical protein
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            • ABA70580.1
            		 13796 - 15676 (-) hypothetical protein
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              • ABA70581.1
              		 16301 - 18194 (-) hypothetical protein
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                • ABA70582.1
                • pcbAB
                		 23318 - 34654 (-) alpha-aminoadypil-cysteinyl-valine synthetase
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                  • ABA70583.1
                  • pcbC
                  		 35670 - 36665 (+) isopenicillin N synthetase
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                    • ABA70584.1
                    • penDE
                    		 38163 - 39437 (+) acyl-coenzyme A:Isopenicillin N acyltransferase
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                      • ABA70585.1
                      		 40456 - 42020 (-) hypothetical protein
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                        • ABA70586.1
                        		 42560 - 43915 (+) hypothetical protein
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                          • ABA70587.1
                          		 46934 - 47398 (+) hypothetical protein
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                            • ABA70588.1
                            		 52260 - 52819 (-) hypothetical protein
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                              • ABA70589.1
                              		 54319 - 55297 (+) hypothetical protein
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                                • ABA70590.1
                                		 55514 - 56662 (+) hypothetical protein
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  pcbAB
                                  Substrates
                                  2-aminoadipic acid (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  pcbAB
                                  Substrates
                                  cysteine (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  pcbAB
                                  Substrates
                                  valine (evidence: Structure-based inference [1], [2])
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: next

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2024-07-24
                                  MIBiG v4 annotathon
                                  • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                  • (ID: X3QVFXOIMTNXSB4JQGP4RI6A)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2015-06-12
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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