BGC0000405 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000405 (Penicillium chrysogenum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	59,497	δ-(L-α-aminoadipyl)-L-cysteine-D-valine/isopenicillin N/benzylpenicillin/phenoxymethylpenicillin	NRPS:Type I	100%

BGC0000405 - Region 1 - NRPS

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Location: 1 - 59,497 nt. (total: 59,497 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 59,498
Label		BGC0000405

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000405	1.00	NRP	δ-(L-α-aminoadipyl)-L-cysteine-D-valine, isopenicillin N, benzylpenicillin, phenoxymethylpenicillin	Penicillium chrysogenum
BGC0000404	0.74	NRP	penicillin	Penicillium chrysogenum
BGC0000900	0.31	Other	ferrichrome	Aspergillus oryzae
BGC0001825	0.27	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.27	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001824	0.26	NRP	xefoampeptides A-G	Xenorhabdus beddingii
BGC0001135	0.25	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001873	0.25	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001128	0.25	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286	0.25	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000405	1.00	NRP	δ-(L-α-aminoadipyl)-L-cysteine-D-valine, isopenicillin N, benzylpenicillin, phenoxymethylpenicillin	Penicillium chrysogenum
BGC0000404	0.82	NRP	penicillin	Penicillium chrysogenum
BGC0000900	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0000348	0.64	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001825	0.60	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.60	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001824	0.59	NRP	xefoampeptides A-G	Xenorhabdus beddingii
BGC0001135	0.59	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001873	0.58	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0001128	0.58	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 5676 - 57052:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Aad - Cys - D-Val)

Direct lookup in NORINE database: strict or relaxed

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NRPS/PKS substrate predictions

pcbAB

Search NORINE for peptide: strict or relaxed

AMP-binding (328..741): Aad

nrpys: Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: aad (Aad)
Single AA prediction:: aad (Aad)

Stachelhaus prediction details:

Stachelhaus sequence:: EPRNIVEFVK
Nearest Stachelhaus code(s):: Aad EPRNIVEFVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1422..1833): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DHESDVGITK
Nearest Stachelhaus code(s):: Cys DHESDVGITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2505..2915): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DFESTAAVYK
Nearest Stachelhaus code(s):: Val DFESTAAVYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)