BGC0000405: δ-(L-α-aminoadipyl)-L-cysteine-D-valine biosynthetic gene cluster from Penicillium chrysogenum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 1 - 59,497 nt. (total: 59,497 nt).
This entry is originally from NCBI GenBank EF601124.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
other genes
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000405
Short description δ-(L-α-aminoadipyl)-L-cysteine-D-valine biosynthetic gene cluster from Penicillium chrysogenum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Beta-lactam)
Loci NCBI GenBank: EF601124.1
Compounds
  • δ-(L-α-aminoadipyl)-L-cysteine-D-valine
  • isopenicillin N
  • benzylpenicillin
  • phenoxymethylpenicillin
Species Penicillium chrysogenum [taxonomy]
References
Chemical products information
δ-(L-α-aminoadipyl)-L-cysteine-D-valine [synonyms: acv]
Copy SMILES
C14H24N3O6S1
Chemical database entries
ChEBI
isopenicillin N [synonyms: ipn]
Copy SMILES
C14H21N3O6S1
Chemical database entries
ChEBI
benzylpenicillin [synonyms: penicillin g]
Copy SMILES
C16H17N2Na1O4S1
Chemical database entries
ChEBI
phenoxymethylpenicillin [synonyms: penicillin v]
(no structure information available)
C16H18N2O5S1
Chemical database entries
ChEMBL
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABR12607.1
1 - 1659 (-) isoamyl alcohol oxidase
copy AA seq
copy Nt seq
  • ABR12608.1
4468 - 5130 (-) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12609.1
5821 - 7011 (-) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12610.1
7456 - 8991 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12611.1
9836 - 12187 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12612.1
14735 - 15622 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12613.1
16080 - 17960 (-) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12614.1
18585 - 20930 (-) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12615.1
  • pcbAB
25677 - 37052 (-) ACV synthetase
  • Scaffold biosynthesis
  • Mutation phenotype: no penicillin production
Activity assay
copy AA seq
copy Nt seq
  • ABR12616.1
  • pcbC
38068 - 39063 (+) IPN synthase
  • Tailoring (Oxidation)
  • Mutation phenotype: accumulation of ACV tripeptide
Activity assay
copy AA seq
copy Nt seq
  • ABR12617.1
  • penDE
40561 - 41835 (+) IPN:acyltransferase
  • Tailoring (Unknown)
  • Mutation phenotype: accumulation of isopenicillin N
Activity assay
copy AA seq
copy Nt seq
  • ABR12618.1
42849 - 43628 (-) probable oxidoreductase
copy AA seq
copy Nt seq
  • ABR12619.1
44942 - 46297 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12620.1
49317 - 49781 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12621.1
50291 - 50914 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ABR12622.1
  • erg25
56117 - 57262 (-) C4-methylsterol oxidase
copy AA seq
copy Nt seq
NRP-specific information
Subclass Beta-lactam
Cyclic? no
Release type
  • Macrolactamization
NRP-synthases
Gene Modules
ABR12615.1
Module 0
Specificity: 2-Amino-adipic-acid
Evidence for specificity:
  • Activity assay
Module 1
Specificity: Cysteine
Evidence for specificity:
  • Activity assay
Condensation domain type: DCL
Module 2
Specificity: Valine
Evidence for specificity:
  • Activity assay
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 53KWSSAVU3NHQPX32A2FHV6D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains