BGC0000408: polymyxin biosynthetic gene cluster from Paenibacillus polymyxa
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Location: 1 - 41,040 nt. (total: 41,040 nt).
This entry is originally from NCBI GenBank EU371992.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000408
Short description polymyxin biosynthetic gene cluster from Paenibacillus polymyxa
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
EU371992.1
via
Compounds
  • polymyxin
Species Paenibacillus polymyxa [taxonomy]
References
Chemical products information
polymyxin Evidence:
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C56H100N16O17S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACA97576.1
 1 - 14862 (+) PmxA
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    • ACA97577.1
    		 15017 - 18325 (+) PmxB
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      • ACA97578.1
      		 18315 - 20141 (+) PmxC
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        • ACA97579.1
        		 20138 - 21871 (+) PmxD
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          • ACA97580.1
          		 22102 - 41040 (+) PmxE
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            Biosynthesis information

            Biosynthetic modules

            Name
            Unk01
            Type
            nrps-type1
            Genes
            ACA97576.1
            Substrates
            leucine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk02
            Type
            nrps-type1
            Genes
            ACA97576.1
            Substrates
            threonine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk03
            Type
            nrps-type1
            Genes
            ACA97576.1
            Substrates
            2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk04
            Type
            nrps-type1
            Genes
            ACA97576.1
            Substrates
            2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk05
            Type
            nrps-type1
            Genes
            ACA97577.1
            Substrates
            threonine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk06
            Type
            nrps-type1
            Genes
            ACA97580.1
            Substrates
            2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk07
            Type
            nrps-type1
            Genes
            ACA97580.1
            Substrates
            threonine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk08
            Type
            nrps-type1
            Genes
            ACA97580.1
            Substrates
            2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk09
            Type
            nrps-type1
            Genes
            ACA97580.1
            Substrates
            2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Name
            Unk10
            Type
            nrps-type1
            Genes
            ACA97580.1
            Substrates
            2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
            Integrated Monomers
            Domains
            adenylation
            Annotation changelog

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Added NRP substrate specificities
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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