BGC0000408

BGC0000408: polymyxin biosynthetic gene cluster from Paenibacillus polymyxa

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Location: 1 - 41,040 nt. (total: 41,040 nt).
This entry is originally from NCBI GenBank EU371992.1.

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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General

Compounds

Genes

NRP

History

NRPS/PKS domains

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000408
Short description	polymyxin biosynthetic gene cluster from Paenibacillus polymyxa
Status	Minimal annotation: no A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: Unknown Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	NRP
Loci	NCBI GenBank: EU371992.1
Compounds	polymyxin
Species	Paenibacillus polymyxa [taxonomy]
References	Identification of a polymyxin synthetase gene cluster of Paenibacillus polymyxa and heterologous expression of the gene in Bacillus subtilis. Choi SK et al., J Bacteriol (2009) PMID:19304848

Chemical products information

polymyxin

Copy SMILES

C₅₆H₁₀₀N₁₆O₁₇S₁

Chemical database entries
PubCHEM

List of genes involved in compound(s) production

Identifiers	Position	Product	Extra
ACA97576.1	1 - 14862 (+)	PmxA	copy AA seq copy Nt seq
ACA97577.1	15017 - 18325 (+)	PmxB	copy AA seq copy Nt seq
ACA97578.1	18315 - 20141 (+)	PmxC	copy AA seq copy Nt seq
ACA97579.1	20138 - 21871 (+)	PmxD	copy AA seq copy Nt seq
ACA97580.1	22102 - 41040 (+)	PmxE	copy AA seq copy Nt seq

NRP-specific information

Subclass	N/A
Cyclic?	no

NRP-synthases

Gene	Modules
ACA97576.1	Module ? Specificity: leucine Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: threonine Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: 2,4-diaminobutyric acid Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: 2,4-diaminobutyric acid Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
ACA97577.1	Module ? Specificity: threonine Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
ACA97580.1	Module ? Specificity: 2,4-diaminobutyric acid Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: threonine Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: 2,4-diaminobutyric acid Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: 2,4-diaminobutyric acid Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction
	Module ? Specificity: 2,4-diaminobutyric acid Evidence for specificity: Structure-based inference Mass spectrometry Sequence-based prediction

Annotation changelog

MIBiG version	Submitter	Notes
1.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4
3.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Updated bioactivity data Added NRP substrate specificities
3.1	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Update chemical activity to schema version 2.11

Detailed domain annotation

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