BGC0000409: porothramycin A biosynthetic gene cluster from Streptomyces albus subsp. albus
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Location: 1 - 54,514 nt. (total: 54,514 nt).
This entry is originally from NCBI GenBank HQ872605.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000409
Short description porothramycin A biosynthetic gene cluster from Streptomyces albus subsp. albus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: HQ872605.1
Compounds
  • porothramycin A
Species Streptomyces albus subsp. albus [taxonomy]
References
Chemical products information
porothramycin A
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C18H21N3O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEA29651.1
 912 - 1421 (-) hypothetical protein
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  • AEA29652.1
 1698 - 1946 (-) hypothetical protein
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  • AEA29653.1
 2151 - 2420 (-) hypothetical protein
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  • AEA29654.1
 2739 - 2900 (+) hypothetical protein
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  • AEA29655.1
 3342 - 3830 (-) putative transcription regulator
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  • AEA29624.1
 4507 - 5040 (+) NADPH-dependent FMN reductase
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  • AEA29625.1
 5550 - 6233 (+) Por2
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  • AEA29626.1
 6261 - 8495 (-) Por3
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  • AEA29627.1
 8558 - 9508 (+) putative transcriptional regulator
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  • AEA29628.2
 9538 - 10977 (-) putative flavin containing oxidoreductase
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  • AEA29629.1
 11016 - 12218 (-) putative transmembrane efflux protein
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  • AEA29630.1
 12243 - 13019 (-) putative hydroxylase/glyoxylase
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  • AEA29631.1
 13087 - 14955 (-) putative amidotransferase
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  • AEA29632.1
 15034 - 16227 (-) putative cytochrom P-450 hydroxylase
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  • AEA29633.1
 16262 - 17314 (-) putative methyltransferase
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  • AEA29634.1
 17353 - 19152 (-) Por11
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  • AEA29635.2
 19211 - 20626 (-) putative oxidoreductase
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  • AEA29636.2
 21176 - 21646 (+) putative L-DOPA 2,3-dioxygenase
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  • AEA29637.2
 21643 - 22560 (+) putative tyrosine hydroxylase
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  • AEA29638.1
 22557 - 23450 (+) putative F-420 dependent reductase
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  • AEA29639.2
 23447 - 24316 (+) Por16
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  • AEA29640.1
 24313 - 25560 (+) putative kinureninase
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  • AEA29641.1
 25782 - 26825 (+) putative C aromatic methyltransferase
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  • AEA29642.1
 26818 - 27684 (+) putative aryl formamidase
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  • AEA29643.1
 27692 - 29515 (+) putative nonribosomal peptide synthetase
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  • AEA29644.1
 29517 - 35333 (+) putative nonribosomal peptide synthetase and kinurenine monooxygenase
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  • AEA29645.1
 35379 - 36251 (+) Por22
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  • AEA29646.2
 36309 - 37742 (+) putative FMNH2-dependent monooxygenase
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  • AEA29647.1
 37867 - 39204 (+) putative glutamin synthetase
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  • AEA29648.1
 39267 - 41690 (+) putative aminomethyltransferase
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  • AEA29649.1
 41735 - 42793 (+) putative O-methyltransferase
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  • AEA29650.1
 42891 - 44237 (+) putative flavin containing monooxygenase
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  • AEA29656.1
 44420 - 45829 (+) putative endoglykoceramidase
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  • AEA29657.1
 46135 - 47034 (-) putative acetyltransferase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
AEA29643.1
Module ?
Specificity: 3-methoxyanthranilic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
AEA29644.1
Module ?
Specificity: 4R-propylproline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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