LOCUS       BGC0000412             15023 bp    DNA     linear   BCT 06-FEB-2001
DEFINITION  Pseudomonas aeruginosa dihydroaeruginoic acid synthetase (pchE),
            pyochelin synthetase (pchF), reductase (pchG), ABC transporter
            (pchH), and ABC transporter (pchI) genes, complete cds.
ACCESSION   BGC0000412
VERSION     BGC0000412
KEYWORDS    .
SOURCE      Pseudomonas aeruginosa PAO1
  ORGANISM  Pseudomonas aeruginosa PAO1
            Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
COMMENT     On Feb 6, 2001 this sequence version replaced AF074705.1.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 19:05:44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15023
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15023
                     /db_xref="taxon:208964"
                     /mol_type="genomic DNA"
                     /organism="Pseudomonas aeruginosa PAO1"
                     /strain="PAO1"
     subregion       1..15023
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="NRP"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15023
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            805..5121
                     /gene="pchE"
     CDS             805..5121
                     /NRPS_PKS="Domain: PP-binding (12-80). E-value: 6.1e-09.
                     Score: 28.2. Matches aSDomain:
                     nrpspksdomains_pchE_PP-binding.1"
                     /NRPS_PKS="Domain: Heterocyclization (101-398). E-value:
                     1.1e-113. Score: 371.5. Matches aSDomain:
                     nrpspksdomains_pchE_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (562-950). E-value: 2.9e-91.
                     Score: 297.9. Matches aSDomain:
                     nrpspksdomains_pchE_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1355-1423). E-value: 5.1e-19.
                     Score: 60.1. Matches aSDomain: nrpspksdomains_pchE_PCP.1"
                     /codon_start=1
                     /gene="pchE"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 275;
                     E-value: 1.7e-83)"
                     /gene_kind="biosynthetic"
                     /note="peptide synthetase"
                     /product="dihydroaeruginoic acid synthetase"
                     /protein_id="AAC83656.1"
                     /sec_met_domain="Condensation (E-value: 4.2e-47, bitscore:
                     149.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-97, bitscore:
                     314.9, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 9.1e-18, bitscore:
                     53.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLPPDSRTALRDWLTEQLADLLGEPLADVRALADDDDLLGCGLD
                     SIRLMYLQERLRARGSTLDFAQLAQRPCLGAWLDLLACADRLSAPATVALPTAQDRDQP
                     FELSSVQQAYWLGRGAGEVLGNVSCHAFLEFRTRDVDPQRLAAAAECVRQRHPMLRARF
                     LDGRQQILPTPPLSCFDLQDWRTLQVDEAERDWQALRDWRAHECLAVERGQVFLLGLVR
                     MPGGEDRLWLSLDLLAADVESLRLLLAELGVAYLAPERLAEPPALHFADYLAHRAAQRA
                     EAAARARDYWLERLPRLPDAPALPLACAPESIRQPRTRRLAFQLSAGESRRLERLAAQH
                     GVTLSSVFGCAFALVLARWSESAEFLLNVPLFDRHADDPRIGEVIADFTTLLLLECRMQ
                     AGVSFAEAVKSFQRNLHGAIDHAAFPALEVLREARRQGQPRSAPVVFASNLGEEGFVPA
                     AFRDAFGDLHDMLSQTPQVWLDHQLYRVGDGILLAWDSVVGLFPEGLPETMFEAYVGLL
                     QRLCDSAWGQPADLPLPWAQQARRALLNGQPACATARTLHRDFFLRAAEAPDADALLYR
                     DQRVTRGELAERALRIAGGLREAGVRPGDAVEVSLPRGPQQVAAVFGVLAAGACYVPLD
                     IDQPPARRRLIEEAAGVCLAITEEDDPQALPPRLDVQRLLRGPALAAPVPLAPQASAYV
                     IYTSGSTGVPKGVEVSHAAAINTIDALLDLLRVNASDRLLAVSALDFDLSVFDLFGGLG
                     AGASLVLPAQEQARDAAAWAEAIQRHAVSLWNSAPALLEMALSLPASQADYRSLRAVLL
                     SGDWVALDLPGRLRPRCAEGCRLHVLGGATEAGIWSNLQSVDTVPPHWRSIPYGRPLPG
                     QAYRVVDTHGRDVPDLVVGELWIGGASLARGYRNDPELSARRFVHDAQGRWYRTGDRGR
                     YWGDGTLEFLGRVDQQVKVRGQRIELGEVEAALCAQAGVESACAAVLGGGVASLGAVLV
                     PRLAPRAEGSMDLPAAQPFAGLAEAEAVLTREILGALLEAPLELDDGLRRRWLDWLADS
                     AASALPSLDEALRRLGWQAAGLTAMGNALRGLLAGEQAPAALLLDPWLAPQAVAARLPD
                     GREALARLLEALPTPAAGERLRVAVLDTRAGLWLDQGMASLLRPGLELTLFERSRVLLD
                     AAATRLPERIVVQALDDGLLPAEHLGRYDRVISFAALHAYEASREGLALAAALLRPQGR
                     LLLVDLLCESPLALLGAALLDDRPLRLAELPSLLADLAAAGLAPRCLWRSERIALVEAL
                     APGLGLDAAALQAGLEQRLPQAMRPERLWCLPSLPLNGNGKVDRRRLAESMTRALGECR
                     HEPSAEEPLEAHEQALAECWEAVLKRPVRRREASFFSLGGDSLLATRLLAGIRERFGVR
                     LGMADFYRQPTLAGLARHLQVQTVEIEETQLEEGVL"
     aSDomain        841..1044
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchE_PP-binding.1"
                     /evalue="6.10E-09"
                     /label="pchE_PP-binding.1"
                     /locus_tag="pchE"
                     /protein_end="80"
                     /protein_start="12"
                     /score="28.2"
                     /tool="antismash"
                     /translation="DWLTEQLADLLGEPLADVRALADDDDLLGCGLDSIRLMYLQERLR
                     ARGSTLDFAQLAQRPCLGAWLDL"
     aSDomain        1108..1998
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchE_Heterocyclization.1"
                     /evalue="1.10E-113"
                     /label="pchE_Heterocyclization.1"
                     /locus_tag="pchE"
                     /protein_end="398"
                     /protein_start="101"
                     /score="371.5"
                     /tool="antismash"
                     /translation="DQPFELSSVQQAYWLGRGAGEVLGNVSCHAFLEFRTRDVDPQRLA
                     AAAECVRQRHPMLRARFLDGRQQILPTPPLSCFDLQDWRTLQVDEAERDWQALRDWRAH
                     ECLAVERGQVFLLGLVRMPGGEDRLWLSLDLLAADVESLRLLLAELGVAYLAPERLAEP
                     PALHFADYLAHRAAQRAEAAARARDYWLERLPRLPDAPALPLACAPESIRQPRTRRLAF
                     QLSAGESRRLERLAAQHGVTLSSVFGCAFALVLARWSESAEFLLNVPLFDRHADDPRIG
                     EVIADFTTLLLLECRM"
     aSModule        1108..5073
                     /complete
                     /domains="nrpspksdomains_pchE_Heterocyclization.1"
                     /domains="nrpspksdomains_pchE_AMP-binding.1"
                     /domains="nrpspksdomains_pchE_PCP.1"
                     /locus_tags="pchE"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1132..1158
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0001"
                     /evalue="6.80E-03"
                     /label="Cy1"
                     /locus_tag="pchE"
                     /protein_end="118"
                     /protein_start="109"
                     /score="9.3"
                     /tool="antismash"
                     /translation="VQQAYWLGR"
     CDS_motif       1216..1296
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0002"
                     /evalue="6.60E-07"
                     /label="C2_DCL_024-062"
                     /locus_tag="pchE"
                     /protein_end="164"
                     /protein_start="137"
                     /score="21.6"
                     /tool="antismash"
                     /translation="RDVDPQRLAAAAECVRQRHPMLRARFL"
     CDS_motif       1489..1533
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0003"
                     /evalue="1.00E-03"
                     /label="Cy3"
                     /locus_tag="pchE"
                     /protein_end="243"
                     /protein_start="228"
                     /score="12.4"
                     /tool="antismash"
                     /translation="RLWLSLDLLAADVES"
     CDS_motif       1825..1884
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0004"
                     /evalue="5.50E-07"
                     /label="Cy4"
                     /locus_tag="pchE"
                     /protein_end="360"
                     /protein_start="340"
                     /score="22.4"
                     /tool="antismash"
                     /translation="GVTLSSVFGCAFALVLARWS"
     CDS_motif       1897..1929
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0005"
                     /evalue="1.50E-03"
                     /label="afterCy4"
                     /locus_tag="pchE"
                     /protein_end="375"
                     /protein_start="364"
                     /score="11.3"
                     /tool="antismash"
                     /translation="FLLNVPLFDRH"
     CDS_motif       1939..1995
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0006"
                     /evalue="3.20E-07"
                     /label="Cy5"
                     /locus_tag="pchE"
                     /protein_end="397"
                     /protein_start="378"
                     /score="22.6"
                     /tool="antismash"
                     /translation="PRIGEVIADFTTLLLLECR"
     CDS_motif       2059..2100
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0007"
                     /evalue="8.90E-04"
                     /label="afterCy5"
                     /locus_tag="pchE"
                     /protein_end="432"
                     /protein_start="418"
                     /score="12.2"
                     /tool="antismash"
                     /translation="IDHAAFPALEVLRE"
     CDS_motif       2218..2289
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0008"
                     /evalue="6.30E-08"
                     /label="Cy7"
                     /locus_tag="pchE"
                     /protein_end="495"
                     /protein_start="471"
                     /score="25.3"
                     /tool="antismash"
                     /translation="SQTPQVWLDHQLYRVGDGILLAWD"
     aSDomain        2491..3654
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchE_AMP-binding.1"
                     /evalue="2.90E-91"
                     /label="pchE_AMP-binding.1"
                     /locus_tag="pchE"
                     /protein_end="950"
                     /protein_start="562"
                     /score="297.9"
                     /tool="antismash"
                     /translation="RAAEAPDADALLYRDQRVTRGELAERALRIAGGLREAGVRPGDAV
                     EVSLPRGPQQVAAVFGVLAAGACYVPLDIDQPPARRRLIEEAAGVCLAITEEDDPQALP
                     PRLDVQRLLRGPALAAPVPLAPQASAYVIYTSGSTGVPKGVEVSHAAAINTIDALLDLL
                     RVNASDRLLAVSALDFDLSVFDLFGGLGAGASLVLPAQEQARDAAAWAEAIQRHAVSLW
                     NSAPALLEMALSLPASQADYRSLRAVLLSGDWVALDLPGRLRPRCAEGCRLHVLGGATE
                     AGIWSNLQSVDTVPPHWRSIPYGRPLPGQAYRVVDTHGRDVPDLVVGELWIGGASLARG
                     YRNDPELSARRFVHDAQGRWYRTGDRGRYWGDGTLEFLGRVDQQVKVR"
     CDS_motif       2668..2709
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0009"
                     /evalue="3.90E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="pchE"
                     /protein_end="635"
                     /protein_start="621"
                     /score="13.9"
                     /tool="antismash"
                     /translation="FGVLAAGACYVPLD"
     CDS_motif       2878..2937
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0010"
                     /evalue="6.00E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="pchE"
                     /protein_end="711"
                     /protein_start="691"
                     /score="31.0"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGVPKGVEVSH"
     CDS_motif       3460..3546
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0011"
                     /evalue="1.10E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="pchE"
                     /protein_end="914"
                     /protein_start="885"
                     /score="46.5"
                     /tool="antismash"
                     /translation="DLVVGELWIGGASLARGYRNDPELSARRF"
     CDS_motif       3619..3684
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0012"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="pchE"
                     /protein_end="960"
                     /protein_start="938"
                     /score="36.7"
                     /tool="antismash"
                     /translation="FLGRVDQQVKVRGQRIELGEVE"
     CDS_motif       4261..4287
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchE_0013"
                     /evalue="6.60E+00"
                     /label="afterCy4"
                     /locus_tag="pchE"
                     /protein_end="1161"
                     /protein_start="1152"
                     /score="0.5"
                     /tool="antismash"
                     /translation="LELTLFERS"
     aSDomain        4870..5073
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchE_PCP.1"
                     /evalue="5.10E-19"
                     /label="pchE_PCP.1"
                     /locus_tag="pchE"
                     /protein_end="1423"
                     /protein_start="1355"
                     /score="60.1"
                     /tool="antismash"
                     /translation="EQALAECWEAVLKRPVRRREASFFSLGGDSLLATRLLAGIRERFG
                     VRLGMADFYRQPTLAGLARHLQV"
     gene            5118..10547
                     /gene="pchF"
     CDS             5118..10547
                     /NRPS_PKS="Domain: Heterocyclization (65-363). E-value:
                     8.5e-105. Score: 342.2. Matches aSDomain:
                     nrpspksdomains_pchF_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (519-915). E-value: 3.8e-91.
                     Score: 297.5. Matches aSDomain:
                     nrpspksdomains_pchF_AMP-binding.1"
                     /NRPS_PKS="Domain: nMT (1131-1343). E-value: 4.5e-56.
                     Score: 181.3. Matches aSDomain: nrpspksdomains_pchF_nMT.1"
                     /NRPS_PKS="Domain: PCP (1412-1485). E-value: 1.7e-12.
                     Score: 39.2. Matches aSDomain: nrpspksdomains_pchF_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1538-1797). E-value:
                     3.6e-12. Score: 39.0. Matches aSDomain:
                     nrpspksdomains_pchF_Thioesterase.1"
                     /codon_start=1
                     /gene="pchF"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic"
                     /note="peptide synthetase"
                     /product="pyochelin synthetase"
                     /protein_id="AAC83657.1"
                     /sec_met_domain="Condensation (E-value: 8.5e-38, bitscore:
                     118.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.7e-102, bitscore:
                     331.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.7e-11, bitscore:
                     31.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLGELLETCRSRRIELWSEAGRLRYRAPQGALDAGLAERLRAER
                     EALLEHLEGGPGWRAEPDMAHQRFPLTPVQAAYVLGRQAAFDYGGNACQLYAEYDWPAD
                     TDPARLEAAWNAMVERHPMLRAVIEDNAWQRVLPEVPWQRLTVHACAGLDEAAFQAHLE
                     RVRERLDHACAALDQWPVLRPELSIGRDACVLHCSVDFTLVDYASLQLLLGEWRRRYLD
                     PQWTAEPLEATFRDYVGVEQRRRQSPAWQRDRDWWLARLDALPGRPDLPLRVQPDTRST
                     RFRHFHARLDEAAWQALGARAGEHGLSAAGVALAAFAETIGRWSQAPAFCLNLTVLNRP
                     PLHPQLAQVLGDFTALSLLAVDSRHGDSFVERARRIGEQMFDDLDHPTFSGVDLLRELA
                     RRRGRGADLMPVVFTSGIGSVQRLLGDGEAPRAPRYMISQTPQVWLDCQVTDQFGGLEI
                     GWDVRLGLFPEGQAEAMFDDFVGLLRRLAQSPRAWTDGDATEPVEAPPQALPGSARSIA
                     AGFAERALLTPDATAIHDAAGSYSYRQVAQHASALRRVLEAHGAGRGRRVAVMLPKSAA
                     QLVAVIGILQAGAAYVPVDIRQPPLRRQAILASAEVVALVCLESDVPDVGCACVAIDRL
                     AADSAWPPPPAAEVAADDLAYVIYTSGSTGTPKGVMLSHAAVSNTLLDINQRYGVDAND
                     RVLGLAELSFDLSVYDFFGATAAGAQVVLPDPARGSDPSHWAELLERHAITLWNSVPAQ
                     GQMLIDYLESEPQRHLPGPRCVLWSGDWIPVSLPTRWWRRWPDSAAVQPGRRTEAAIWS
                     IEQPIRPQHTELASIPYGRALRGQSVEVLDARGRRCPPGVRGEIHIGGVGLALGYAGDP
                     QRTAERFVRHPDGRRLYRTGDLGRYLADGSIEFLGREDDQVKIRGHRIELAELDAALCA
                     HPQVNLAATVVLGETHERSLASFVTLHAPVEAGEDPRTALDAVRQRAAQALRRDWGSEE
                     GIAAAVAALDRACLASLAAWLAGSGLFASATPLDLATLCQRLGIAEARQRLLRHWLRQL
                     EEGGYLRAEGEGWLGCAERPAQSPEDAWTAFAGCAPAALWPAELVAYLRDSAQSLGEQL
                     AGRISPAALMFPQGSARIAEAMYSQGLHAQALHEAMAEAIAAIVERQPQRRWRLLELGA
                     GTAAASRTVIARLAPLVQRGAEVDYLFTDVSSYFLAAARERFADQPWVRFGRFDMNGDL
                     LDQGVAPHSVDILLSSGALNNALDTPALLAGLRELLSADAWLVIQELTREHNEISVSQS
                     LMMENPRDLRDERRQLFVHTGQWLEWLAAQGGDLACGVVPPGSALDLLGYDVLLARCKT
                     DRARLEPAELLAFVEARVPRYMLPAQLRVLERLPVTGNGKIDRKALTGFARQPQADLRH
                     GVAQAPADELENALLALWREVLDNPSLGVEQDFFGAGGDSLLIAQLIARLRERLESARR
                     HPFDRLLRWALSQPTPRGLAERLRSAPEEGRGPALAAARGVAPAPAGMSRAPLAEGAVA
                     LDPLVRLVPGEGVPRVLVHEGLGTLLPYRPLLRALGEGRPLLGLAVHDSDAYLAIPAEH
                     LNACLGRRYAEALHRAGLREVDLLGYCSGGLVALETAKSLVQRGVRVRQLDIVSSYRIP
                     YRVDDERLLLFSFAATLGLDTAALGFPAPERLGQAVQAALAQTPERLVAEALAGLPGLA
                     DLVALRGRVLQAASGSADAVSVERDTLYRLFCHSVRASQAEAPEPYVGALRLFVPDAGN
                     PLVPRYAEALETQWRAAALGACGIHEVPGGHFDCLGEALAQSLSKPMPEEASR"
     aSDomain        5313..6206
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchF_Heterocyclization.1"
                     /evalue="8.50E-105"
                     /label="pchF_Heterocyclization.1"
                     /locus_tag="pchF"
                     /protein_end="363"
                     /protein_start="65"
                     /score="342.2"
                     /tool="antismash"
                     /translation="HQRFPLTPVQAAYVLGRQAAFDYGGNACQLYAEYDWPADTDPARL
                     EAAWNAMVERHPMLRAVIEDNAWQRVLPEVPWQRLTVHACAGLDEAAFQAHLERVRERL
                     DHACAALDQWPVLRPELSIGRDACVLHCSVDFTLVDYASLQLLLGEWRRRYLDPQWTAE
                     PLEATFRDYVGVEQRRRQSPAWQRDRDWWLARLDALPGRPDLPLRVQPDTRSTRFRHFH
                     ARLDEAAWQALGARAGEHGLSAAGVALAAFAETIGRWSQAPAFCLNLTVLNRPPLHPQL
                     AQVLGDFTALSLLAVDS"
     aSModule        5313..10508
                     /complete
                     /domains="nrpspksdomains_pchF_Heterocyclization.1"
                     /domains="nrpspksdomains_pchF_AMP-binding.1"
                     /domains="nrpspksdomains_pchF_nMT.1"
                     /domains="nrpspksdomains_pchF_PCP.1"
                     /domains="nrpspksdomains_pchF_Thioesterase.1"
                     /final_module
                     /locus_tags="pchF"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       5430..5498
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0001"
                     /evalue="1.40E-10"
                     /label="C2_DCL_024-062"
                     /locus_tag="pchF"
                     /protein_end="127"
                     /protein_start="104"
                     /score="33.5"
                     /tool="antismash"
                     /translation="TDPARLEAAWNAMVERHPMLRAV"
     CDS_motif       5697..5741
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0002"
                     /evalue="1.20E-02"
                     /label="Cy3"
                     /locus_tag="pchF"
                     /protein_end="208"
                     /protein_start="193"
                     /score="9.1"
                     /tool="antismash"
                     /translation="VLHCSVDFTLVDYAS"
     CDS_motif       6033..6092
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0003"
                     /evalue="3.70E-06"
                     /label="Cy4"
                     /locus_tag="pchF"
                     /protein_end="325"
                     /protein_start="305"
                     /score="19.8"
                     /tool="antismash"
                     /translation="GLSAAGVALAAFAETIGRWS"
     CDS_motif       6105..6143
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0004"
                     /evalue="2.70E-04"
                     /label="afterCy4"
                     /locus_tag="pchF"
                     /protein_end="342"
                     /protein_start="329"
                     /score="13.5"
                     /tool="antismash"
                     /translation="FCLNLTVLNRPPL"
     CDS_motif       6144..6203
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0005"
                     /evalue="1.70E-07"
                     /label="Cy5"
                     /locus_tag="pchF"
                     /protein_end="362"
                     /protein_start="342"
                     /score="23.4"
                     /tool="antismash"
                     /translation="HPQLAQVLGDFTALSLLAVD"
     CDS_motif       6264..6311
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0006"
                     /evalue="8.20E-06"
                     /label="afterCy5"
                     /locus_tag="pchF"
                     /protein_end="398"
                     /protein_start="382"
                     /score="18.4"
                     /tool="antismash"
                     /translation="DLDHPTFSGVDLLREL"
     CDS_motif       6426..6467
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0007"
                     /evalue="1.40E-06"
                     /label="Cy7"
                     /locus_tag="pchF"
                     /protein_end="450"
                     /protein_start="436"
                     /score="21.1"
                     /tool="antismash"
                     /translation="ISQTPQVWLDCQVT"
     aSDomain        6675..7862
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchF_AMP-binding.1"
                     /evalue="3.80E-91"
                     /label="pchF_AMP-binding.1"
                     /locus_tag="pchF"
                     /protein_end="915"
                     /protein_start="519"
                     /score="297.5"
                     /tool="antismash"
                     /translation="FAERALLTPDATAIHDAAGSYSYRQVAQHASALRRVLEAHGAGRG
                     RRVAVMLPKSAAQLVAVIGILQAGAAYVPVDIRQPPLRRQAILASAEVVALVCLESDVP
                     DVGCACVAIDRLAADSAWPPPPAAEVAADDLAYVIYTSGSTGTPKGVMLSHAAVSNTLL
                     DINQRYGVDANDRVLGLAELSFDLSVYDFFGATAAGAQVVLPDPARGSDPSHWAELLER
                     HAITLWNSVPAQGQMLIDYLESEPQRHLPGPRCVLWSGDWIPVSLPTRWWRRWPDSAAV
                     QPGRRTEAAIWSIEQPIRPQHTELASIPYGRALRGQSVEVLDARGRRCPPGVRGEIHIG
                     GVGLALGYAGDPQRTAERFVRHPDGRRLYRTGDLGRYLADGSIEFLGREDDQVKIR"
     CDS_motif       6864..6902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0008"
                     /evalue="3.60E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="pchF"
                     /protein_end="595"
                     /protein_start="582"
                     /score="14.0"
                     /tool="antismash"
                     /translation="GILQAGAAYVPVD"
     CDS_motif       7002..7031
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0009"
                     /evalue="6.80E+01"
                     /label="Cy3"
                     /locus_tag="pchF"
                     /protein_end="638"
                     /protein_start="628"
                     /score="-2.4"
                     /tool="antismash"
                     /translation="CVAIDRLAAD"
     CDS_motif       7080..7139
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0010"
                     /evalue="5.50E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="pchF"
                     /protein_end="674"
                     /protein_start="654"
                     /score="34.2"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGTPKGVMLSH"
     CDS_motif       7662..7751
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0011"
                     /evalue="2.00E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="pchF"
                     /protein_end="878"
                     /protein_start="848"
                     /score="42.5"
                     /tool="antismash"
                     /translation="PPGVRGEIHIGGVGLALGYAGDPQRTAERF"
     CDS_motif       7827..7889
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0012"
                     /evalue="7.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="pchF"
                     /protein_end="924"
                     /protein_start="903"
                     /score="34.0"
                     /tool="antismash"
                     /translation="FLGREDDQVKIRGHRIELAEL"
     aSDomain        8511..9146
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchF_nMT.1"
                     /domain_subtype="nMT"
                     /evalue="4.50E-56"
                     /label="pchF_nMT.1"
                     /locus_tag="pchF"
                     /protein_end="1343"
                     /protein_start="1131"
                     /score="181.3"
                     /tool="antismash"
                     /translation="QGLHAQALHEAMAEAIAAIVERQPQRRWRLLELGAGTAAASRTVI
                     ARLAPLVQRGAEVDYLFTDVSSYFLAAARERFADQPWVRFGRFDMNGDLLDQGVAPHSV
                     DILLSSGALNNALDTPALLAGLRELLSADAWLVIQELTREHNEISVSQSLMMENPRDLR
                     DERRQLFVHTGQWLEWLAAQGGDLACGVVPPGSALDLLGYDVLLARCKT"
     CDS_motif       8682..8711
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0013"
                     /evalue="1.90E+01"
                     /label="Cy3"
                     /locus_tag="pchF"
                     /protein_end="1198"
                     /protein_start="1188"
                     /score="-0.6"
                     /tool="antismash"
                     /translation="VDYLFTDVSS"
     CDS_motif       9282..9305
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0014"
                     /evalue="7.00E+01"
                     /label="afterCy4"
                     /locus_tag="pchF"
                     /protein_end="1396"
                     /protein_start="1388"
                     /score="-2.6"
                     /tool="antismash"
                     /translation="LTGFARQP"
     aSDomain        9354..9572
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchF_PCP.1"
                     /evalue="1.70E-12"
                     /label="pchF_PCP.1"
                     /locus_tag="pchF"
                     /protein_end="1485"
                     /protein_start="1412"
                     /score="39.2"
                     /tool="antismash"
                     /translation="ENALLALWREVLDNPSLGVEQDFFGAGGDSLLIAQLIARLRERLE
                     SARRHPFDRLLRWALSQPTPRGLAERLR"
     aSDomain        9732..10508
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pchF_Thioesterase.1"
                     /evalue="3.60E-12"
                     /label="pchF_Thioesterase.1"
                     /locus_tag="pchF"
                     /protein_end="1797"
                     /protein_start="1538"
                     /score="39.0"
                     /tool="antismash"
                     /translation="HEGLGTLLPYRPLLRALGEGRPLLGLAVHDSDAYLAIPAEHLNAC
                     LGRRYAEALHRAGLREVDLLGYCSGGLVALETAKSLVQRGVRVRQLDIVSSYRIPYRVD
                     DERLLLFSFAATLGLDTAALGFPAPERLGQAVQAALAQTPERLVAEALAGLPGLADLVA
                     LRGRVLQAASGSADAVSVERDTLYRLFCHSVRASQAEAPEPYVGALRLFVPDAGNPLVP
                     RYAEALETQWRAAALGACGIHEVPGGHFDCLGEALAQ"
     CDS_motif       9918..9974
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pchF_0015"
                     /evalue="2.10E-05"
                     /label="NRPS-te1"
                     /locus_tag="pchF"
                     /protein_end="1619"
                     /protein_start="1600"
                     /score="17.1"
                     /tool="antismash"
                     /translation="DLLGYCSGGLVALETAKSL"
     gene            10544..11593
                     /gene="pchG"
     CDS             10544..11593
                     /codon_start=1
                     /gene="pchG"
                     /gene_functions="other (smcogs) SMCOG1099:hypothetical
                     protein (Score: 347; E-value: 2.1e-105)"
                     /gene_kind="other"
                     /note="11000"
                     /product="reductase"
                     /protein_id="AAK01463.1"
                     /transl_table=11
                     /translation="MSDVRSVVVAGSRFGQFYAAGVAADPRFVLRGILGQGSRRSRALA
                     ERLGVETWCEVEALPDDVRLACVAVGGAARGEQGPALAEALMARGIDVLIEHPLLPREW
                     QDLLRSAERLGRRCLLNTFYPQLPAVARFIELGRQLHRRRGIRHLDAACGVQVGFATLD
                     ILAALLEGVGPWSLESPSNDLSAMRGLSLVLAEVPLSLLVLNELAAADDGRMTLLQRVS
                     LTTDRGTLSLLSPHGPLLWTPAVAVPAEDDDGLFALFDEIAGEPLPSAQLWYAEPCSWA
                     QVHQRLWPAAAAEALALLADGDEVRRRNQRSLEVAALWQRIGERLGFPEAPPASLAPAS
                     LEQVLEQAS"
     gene            11590..13302
                     /gene="pchH"
     CDS             11590..13302
                     /codon_start=1
                     /gene="pchH"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 233.5; E-value:
                     8.1e-71)"
                     /gene_kind="transport"
                     /product="ABC transporter"
                     /protein_id="AAK01464.1"
                     /transl_table=11
                     /translation="MTPVLWRLLRTYRWRLAAAMGLQALAGLCSLLPWMLLAWLAEPLA
                     RGQAQPALLALVLLAVLAWLGCQALAAHLAHRVDADLCNDLRLRLLAHLQRLPLDWFGR
                     QGPDGVARLVEQDVRALHQLIAHAPNDLSNLLVVPLVALLWLAWLHPWLLLFCLLPLVL
                     AAAGFLLLRSARYRDLVLRRNAALERLSADYGEFAHNLLLARQYPGAGIQQGAEASAAA
                     FGEAFGAWVKRVGHLAALVYVQLSTPWLLAWVLLGALALDALGVPLALGQACAFLLLLR
                     ALAAPVQALGHGGDALLGARAAAERLQQVFDQAPLAEGRSTREPVDGAVALHGLGHAYE
                     GVEVLADIDLELEDGSLVALVGPSGSGKSTLLHLLARYMDAQRGELEVGGLALKDMPDA
                     VRHRHIALVGQQAAALEISLADNIALFRPDADLQEIRQAARDACLDERIMALPRGYDSV
                     PGRDLQLSGGELQRLALARALLSPASLLLLDEPTSALDPQTARQVLRNLRERGGGRTRV
                     IVAHRLAEVSDADLILVLVAGRLVERGEHAALLAADGAYARLWREQNGAEVAA"
     gene            13299..15023
                     /gene="pchI"
     CDS             13299..15023
                     /codon_start=1
                     /gene="pchI"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 227.2; E-value:
                     6.4e-69)"
                     /gene_kind="transport"
                     /product="ABC transporter"
                     /protein_id="AAK01462.1"
                     /transl_table=11
                     /translation="MTLFERMRALPEDCRAALRRASAWAVLAALLDAACGVLLVPLVEA
                     WFAEGALPWRWVAALLGLSLAQALLQYLALRRGFAAGGSLAAGLVRSLVARLPRLAPPA
                     LRRVAPAEGLLRGPVMQAMGIPAHLLGPLIAALVTPLGVILGLFLIDPSIALGLLLAGA
                     FLAALLRWSGRRNLAAEDARLAAERDAARQLQAFAERQPLLRAAQRESVARQGLEEALR
                     SLHRSTLDLLRRSLPSGLGFALAVQAAFAFALLGGAWAVERQWLDGARLVAVLVLLVRF
                     IEPLAQLTHLDQALRGAWQALDTLLRVFALAPLRSPEPGERPHDASLAAEAVELRLEDG
                     RALLEDISLRLEPGSLNVLVGPSGAGKSSLLALLGRLYDVDAGRVLLGGVDIRRLSETT
                     LAASRNLVFQDNGLFRGSVAWNLRMARADADLEALREAARAVGLLEEIEAWPQGWDSDV
                     GPGGALLSGGQRQRLCLARGLLSTAPLLLLDEPTASLDAASEAQVLRSLLGLRGRRTLL
                     VLTHRPALARQADQVLLLEEGRLRLSGLHADLLVRDDWYAGFVGLAGEESSATVVDR"
ORIGIN
        1 agatctacgg caccgacaag ccgttgcgct acaccatcgt ccagctcggc gtcgaagccc
       61 tggacagccg cctcggctgg ctgcccgagc aactgatacg ccgccccggc ggcgatccgc
      121 ggatcatgag ctgcccggcg ccgcgggcga tgcaggcgtt ggcctcgcag atcgccacct
      181 gccagatgct cggtccgacc cgcgatctct acctcggcgg caaggccctg gagttggccg
      241 cgctcagcgc acagttcctt tccggcgagg ggcgccccgt cgaggagccg cgcatcacct
      301 gctcggaggt cgagcgcatc cacgccgccc gcgacctgct ggtcggcgcc ttgcaggagc
      361 cgccgtcgct ggacacgctg gccagccgcg tgggcatgaa cccgcgcaag ctgactgccg
      421 gctttcgcaa ggtgttcggc gccagcgtat tcggctacct gcaggaatac cgcctgcgcg
      481 aggcgcaccg gatgctctgc gacgaagagg cgaatgtctc cacggtggcc taccgggtgg
      541 gctacagccc ggcgcatttc tccatcgctt tccgcaagcg ctacggcatc tcccccagcg
      601 agatccgctg agtctccgcg acgacccccg acccggccac gggaggggcg tcgccgctgc
      661 gggatgacgc tgcatctaac gaaacagtcc ggctgtctaa agcattgccg gccaggcctc
      721 ccaggcaagt gagataaggt cgcatttgat aatcgttgcc aggaactggc aaccgacctc
      781 agatgcttgc cctagggagc ccccatggat ctgccccccg attcccgtac cgccctgcgc
      841 gactggctga ccgagcagct cgccgacctg ctcggcgaac cgcttgctga cgtgcgcgcc
      901 ctggcggacg acgacgacct gctgggctgc ggcctcgact cgatccgcct gatgtacctg
      961 caggaacgcc tgcgcgcgcg tggctcgacg ctggacttcg cccagttggc gcagcgcccc
     1021 tgcctggggg cctggctcga cctgctggcc tgcgcggacc ggctgtccgc cccggcaacg
     1081 gtcgcgctgc cgacggcgca ggatcgcgat cagccgttcg agctgtcttc cgtgcagcag
     1141 gcctactggc tgggacgtgg cgccggcgag gtgctgggca acgtcagctg ccatgccttt
     1201 ctggaattcc gcacgcggga tgtcgacccg cagcgcctgg ccgcggcggc ggagtgcgtg
     1261 cgtcaacgcc acccgatgtt gcgggcgcgc ttcctcgacg gtcgccagca gatccttccg
     1321 acgccgccgc tgtcctgctt cgacctgcag gactggcgca ccttacaggt ggacgaggcc
     1381 gagcgcgact ggcaggcgct gcgcgactgg cgcgcccatg aatgcctggc ggtggagcgc
     1441 ggccaggtgt tcctgctcgg gctggtgcgc atgccgggcg gcgaggatcg cctctggctg
     1501 agtctcgacc tgcttgccgc cgatgtcgaa agcctgcgcc tgctgctggc cgaactgggc
     1561 gttgcctacc tggcgccgga gcgcctggcg gagccgccgg cgctgcattt cgccgactac
     1621 ctggcgcacc gtgcggcgca acgcgccgag gccgcggcgc gggcccgcga ctactggctg
     1681 gaacgcctgc cgcgcttgcc ggacgcgccg gccctgccgt tggcctgcgc gccggaaagc
     1741 atccgccagc cgcgcacccg gcgcctggca ttccagcttt ccgccggcga gagccggcgc
     1801 ctggagcgtc ttgccgcgca gcatggcgtg accttgtcca gcgtgttcgg ctgcgccttc
     1861 gcgctggtcc tggcgcgctg gagcgaaagc gcggaatttc tcctcaacgt gccgttgttc
     1921 gatcggcatg ccgacgaccc gcgtatcggc gaggtgatcg ccgacttcac caccctgttg
     1981 ctgctggagt gccggatgca ggccggggtg tccttcgccg aggcggtgaa gagcttccag
     2041 cgcaacctcc acggagccat cgaccacgcc gcattccccg ccctggaggt gctccgcgag
     2101 gcgcgccggc agggccagcc acgctcggcg ccggtggtgt tcgccagcaa cctgggcgag
     2161 gagggcttcg tcccggcggc cttccgcgac gctttcggcg atctccacga catgctctcg
     2221 cagaccccgc aggtctggct cgaccaccag ctctaccggg tgggcgacgg tatcctgctg
     2281 gcctgggata gcgtcgtcgg cctgttcccc gaaggtctgc cggaaaccat gttcgaagcc
     2341 tacgtggggc tgctccagcg tctctgcgac agcgcctggg ggcagcccgc cgatctgccg
     2401 ttgccctggg cgcagcaggc gcgccgggcc ctgctcaacg gccagccggc atgcgccacg
     2461 gcgcgcaccc tgcatcgcga cttcttcctt cgcgccgccg aggcgccgga tgccgacgcg
     2521 ctgctctatc gcgaccaacg tgtcacccgc ggcgaactgg ccgagcgtgc gctgcgcatc
     2581 gccggcggcc tgcgcgaagc cggggtgcgc cctggcgacg cggtcgaggt cagcctgccg
     2641 cgcggaccgc agcaggtcgc ggcggtattc ggcgtgctcg ccgcaggcgc ctgctacgtg
     2701 ccgttggaca tcgaccagcc gcccgcacgg cggcgcctga tcgaagaggc cgccggggta
     2761 tgcctggcga tcaccgagga ggacgatccg caggccttgc cgccgcgcct ggatgtccag
     2821 cgcctgctgc gcggcccggc gctggccgcc cccgtgccgc tggcgccgca ggcgagtgcc
     2881 tatgtgatct acacctcggg ctccaccggg gtgcccaagg gcgtcgaggt cagccacgcg
     2941 gcggcgatca ataccatcga cgcgctgctc gacctgctgc gggtgaacgc atcggatcgc
     3001 ttgctggcgg tctccgcgct ggacttcgat ctgtcggtct tcgacctgtt cggcggcctc
     3061 ggcgccggtg ccagcctggt cctgccggcc caggaacagg cgcgcgatgc cgctgcctgg
     3121 gcggaggcta tccagcggca tgcggtgagc ctgtggaact cggcgccggc cttgctggag
     3181 atggccctca gcctgccggc gagccaggcc gactatcgca gtctgcgggc ggtgctgctg
     3241 tccggcgact gggtggccct ggacctgccc ggccgcctgc gcccacgttg tgccgaaggc
     3301 tgccgcctgc atgtgctggg tggcgctacc gaagcgggca tctggtcgaa cctgcagagc
     3361 gtcgatacgg tgccgccgca ctggcgttcg attccctacg gccggccatt gccgggacag
     3421 gcctaccggg tggtcgacac ccacgggcgc gacgtgccgg acctggtggt cggcgagctg
     3481 tggatcggcg gcgccagcct ggcccgcggc tatcgcaacg atcccgaact cagcgcccgg
     3541 cgtttcgtcc acgatgccca gggccgctgg tatcgcaccg gcgatcgcgg tcgctactgg
     3601 ggcgacggta ccctggaatt cctcggtcgg gtcgaccagc aggtgaaagt gcgcggccag
     3661 cgcatcgagt tgggcgaggt ggaggccgcg ctgtgcgccc aggctggcgt ggagagcgcc
     3721 tgcgcggcgg tgctcggcgg tggcgtggcg agcctcggcg cggtgctggt accgcgcctg
     3781 gcgccacggg ccgaaggctc catggatcta ccggccgcac agcccttcgc cggcctggca
     3841 gaggccgagg cggtactcac ccgggaaatc ctcggcgcgc tgctggaggc gccgctggag
     3901 ctagacgacg gtttgcgccg gcgctggctg gactggctag cggactccgc cgccagcgcg
     3961 ctgccgtcgc tcgacgaggc gttgcgccgg ctcggctggc aggccgcggg gctgaccgcg
     4021 atgggcaacg ctctgcgcgg cctgctcgcc ggcgaacagg cgccggccgc gctgctcctc
     4081 gatccctggc tggcgccgca ggcggtggcc gcgcgcctgc cggacggccg cgaggccctg
     4141 gcgcgcctgc tcgaagcgct gccgacgccg gctgccggcg aacgcctgcg ggtggcggtg
     4201 ctggataccc gcgccgggct ctggctcgac cagggcatgg cctcgctgtt gcgcccaggg
     4261 ctggaactga ccctcttcga acgcagccgc gtcctcctcg acgccgccgc cacccgcttg
     4321 ccggaacgga tcgtggtgca ggcgctggac gacggcctgc tacctgccga gcacctcggt
     4381 cgctacgacc gggtgatcag cttcgccgcg ctgcacgcct acgaggccag ccgcgaaggc
     4441 ctggcgctgg cggcggcgct gctgcgcccg cagggccgcc tgttgctggt ggacctgcta
     4501 tgcgagtcgc cactggcgct gctcggtgcg gccttgctcg acgaccggcc gctgcgcctg
     4561 gcggagctgc cgagcctgtt ggccgatctc gccgctgcgg gactggcgcc gcgttgcctg
     4621 tggcgcagcg agcggatcgc cctggtcgag gcgctggcac cgggactcgg gctcgacgcc
     4681 gccgcgctcc aggccggcct ggagcaacgc ctgccccagg cgatgcggcc cgaacgcctg
     4741 tggtgcctgc caagcctgcc gttgaacggc aatggcaagg tcgatcgtcg ccgcctggcc
     4801 gagagcatga cccgcgcact cggcgagtgt cgtcacgagc cctcggcgga ggagccgctg
     4861 gaagcccatg agcaagcgct ggccgagtgc tgggaagcgg ttctcaaacg cccggtgcgt
     4921 cgtcgcgagg cgagcttctt cagcctcggc ggcgacagcc tgctggcgac ccgcctgctg
     4981 gccggcatac gtgagcgttt cggcgtacgc ctgggcatgg ccgacttcta tcgccagccg
     5041 accctggccg gtcttgcccg ccacttgcag gtgcagaccg tcgaaatcga ggaaacccaa
     5101 ctggaagagg gcgtgctatg agcctcggcg aactgctgga aacctgccgc agccggcgca
     5161 tcgaactctg gagcgaggcg ggccgcctgc gctatcgcgc cccccagggt gccctcgacg
     5221 ccggcctcgc cgagcgcctg cgggccgagc gcgaggccct gctggaacac ctggaaggcg
     5281 gccctggctg gcgcgccgaa cccgacatgg cccaccagcg cttcccgctg accccggtgc
     5341 aggccgccta cgtgctgggc cgccaggcgg ccttcgacta cggcggtaac gcctgccagc
     5401 tgtacgccga gtacgactgg ccggccgaca ccgatccggc gcgcctggag gcggcctgga
     5461 acgccatggt cgagcgccac ccgatgctgc gcgcggtgat cgaggacaac gcctggcagc
     5521 gcgtgctgcc cgaggtgccc tggcagcggc tgaccgtgca tgcctgcgcg gggctcgacg
     5581 aggccgcttt ccaggcgcac ctggagcggg tccgcgaacg cctcgaccac gcctgcgcgg
     5641 cgctcgacca gtggccggtc ctgcgccccg agctgagtat cggccgggat gcctgcgtac
     5701 tgcactgctc ggtggatttc accctggtcg actacgccag cctgcaattg ctgcttggcg
     5761 aatggcgccg ccgctatctc gatccgcaat ggacggcgga accgctggag gcgaccttcc
     5821 gcgactatgt cggcgtcgag cagcgccgac gccagtcgcc agcctggcag cgcgaccgcg
     5881 actggtggct ggcgcgtctc gacgcgctac cggggcgtcc cgacctgccg ctgcgggtgc
     5941 agccggacac ccggtccacg cgcttccggc acttccacgc gcgcctcgac gaggccgcct
     6001 ggcaggcgct cggcgcgcgc gccggcgaac acggcctgag cgctgccggc gtggccttgg
     6061 cggccttcgc cgagaccatc ggtcgctgga gccaggcacc ggcgttctgt ctcaacctga
     6121 cggtactcaa ccggccgccg ctgcatccgc agctggcgca ggtgctcggt gacttcaccg
     6181 cgctcagcct gctggcagtg gacagccgcc acggcgacag tttcgtcgag cgtgcccgac
     6241 gcatcggcga gcagatgttc gacgacctcg accacccgac cttcagcggc gtcgacctgc
     6301 tgcgcgaact ggcgcgccgg cgtggtcgcg gcgccgatct gatgccggtg gtgttcacca
     6361 gtggcatcgg cagcgtgcag cgcctgctcg gcgatggcga ggcgccgcgc gcgccacgct
     6421 acatgatcag ccagaccccg caggtctggc tggactgcca ggtcaccgac cagttcggcg
     6481 gcctggagat cggctgggac gtacgcctcg ggttgttccc cgagggccag gcggaagcca
     6541 tgttcgacga cttcgtcggg ctgctccggc gcctggcgca gagcccgcgc gcctggaccg
     6601 acggcgatgc cacggaaccc gtcgaggcgc cgccgcaggc gttgcccggt agtgcccgga
     6661 gcatcgccgc cggtttcgcc gagcgtgccc tgctgacccc cgacgccacg gcgatccacg
     6721 atgccgccgg cagctacagc taccgccagg tcgcccagca cgccagcgcc ctgcgccgcg
     6781 tcctggaagc gcacggcgcg ggccgtggcc ggcgggtcgc ggtgatgctg ccgaaaagcg
     6841 ccgcgcaatt ggtcgcggtg atcggcatcc tccaggccgg cgccgcctat gtgccggtgg
     6901 acatccgcca gcctccgctg cggcgccagg cgatcctcgc cagcgccgaa gtggtcgcgc
     6961 tggtctgcct ggaaagcgat gtcccggacg tcggctgcgc ctgcgtggcc atcgaccggc
     7021 tggccgccga cagcgcctgg ccgccaccgc ccgcggcgga ggtggcggcg gacgacctcg
     7081 cctacgtgat ctacacctcc ggctccaccg gcacgccaaa gggcgtgatg ctcagccatg
     7141 cggcggtgag caacacgctg ctcgacatca accagcgcta cggcgtcgac gccaacgacc
     7201 gcgtcctcgg cctcgccgag ctgagcttcg acctctcggt ctacgacttc ttcggcgcca
     7261 ccgcggcggg ggcccaggtg gtcctcccgg acccggcgcg cggcagcgat ccatcgcact
     7321 gggcggaact gctggaacgc cacgccatca ccctgtggaa ctcggtgccg gcccaaggcc
     7381 agatgctcat cgattacctg gagagcgagc cgcaacgtca cctgccggga ccgcgctgcg
     7441 tgctctggtc cggtgactgg attccggtca gcctgccgac ccgctggtgg cggcgctggc
     7501 cggacagcgc cgctgttcag cctgggcggc gcaccgaggc ggcgatctgg tcgatcgagc
     7561 agccgatccg cccgcagcac accgagctgg ccagcatccc ttatggccgt gccctgcgcg
     7621 ggcagagcgt ggaagtcctg gatgcccgcg ggcggcgctg cccgccgggc gtgcgcggcg
     7681 agatccatat cggcggggtg ggcctggcgc tcggctacgc cggcgatccg cagcgcaccg
     7741 ccgaacgctt cgtccgtcac cccgatggcc gtcgcctgta tcgcaccggc gacctcggcc
     7801 gctacctggc cgacggcagc atcgagttcc tcggccgcga ggacgaccag gtgaagattc
     7861 gcggccaccg catcgaactg gccgaactgg acgccgcgct gtgcgctcat ccgcaggtca
     7921 acctggcggc caccgtggtg ctcggcgaga cccacgagcg cagcctggcc agcttcgtca
     7981 ccctgcatgc gccggtggag gctggcgagg atccgcgtac ggcgctcgac gcggtgcgcc
     8041 agcgggcggc ccaggccttg cgccgcgact ggggcagcga ggagggcatc gccgcggcgg
     8101 tggccgcact cgaccgtgcc tgcctcgcct cgttggccgc ctggctggcc ggcagcggtc
     8161 tgttcgccag tgcgacgccg ctggacttag ccaccctgtg ccagcgcctg ggtatcgccg
     8221 aggcgcgcca gcgcctgctg cgccactggt tgcgccaact ggaggagggc ggctacctgc
     8281 gcgccgaggg cgagggctgg ctgggctgcg ccgagcgtcc cgcgcagagt ccggaggacg
     8341 cctggacggc gttcgccggc tgcgcgccgg cggcgctctg gccggccgag ctggtcgcct
     8401 acctgcgtga cagcgcgcaa tccctcggcg agcaactggc cgggcggatc agcccggcgg
     8461 cgctgatgtt cccgcagggc tcggcgcgca tcgccgaggc catgtacagc cagggcctgc
     8521 atgcccaggc gctgcacgag gccatggccg aggccatcgc cgccatcgtc gagcgccagc
     8581 cgcaacggcg ctggcgcctg ctggagcttg gcgccggcac cgccgccgcc agccgcacgg
     8641 tgatcgcccg gttggcgccg ctggtgcagc gaggggcgga ggtggactac ctgttcaccg
     8701 acgtttccag ctacttcctc gccgccgccc gcgagcgctt cgccgaccag ccgtgggtac
     8761 gcttcggccg cttcgacatg aacggcgatc ttctcgacca gggcgtggcg ccgcactcgg
     8821 tggatatcct gctcagctcc ggggccttga acaacgcgct ggacaccccg gcgctgctgg
     8881 ccggcctgcg cgagttgctg agcgccgacg cctggctggt gatccaggaa ctgacgcgcg
     8941 agcacaacga gatcagcgtc agccagagcc tgatgatgga aaacccgcgc gacctccgcg
     9001 acgagcgccg ccaactgttc gtccacaccg ggcaatggct ggagtggctg gcggcacagg
     9061 gtggcgacct ggcttgtggg gtggtgccgc cgggcagcgc tctcgacctg cttggctacg
     9121 atgtcctgct ggctcgctgc aagaccgacc gcgcccgcct ggagccggcc gagctgctgg
     9181 ccttcgtcga agcgcgggtg ccgcgctaca tgctcccggc gcagttgcgc gtgctcgaac
     9241 gcctgccggt caccggcaac ggcaagatcg accgcaaggc cctgaccggc tttgcccgcc
     9301 agccccaggc ggaccttcgg catggcgtcg cgcaggcacc ggccgacgaa ctggagaatg
     9361 cgctgctggc actctggcgg gaggtgctgg acaacccgtc gctgggcgtc gagcaagact
     9421 tcttcggggc cggcggcgac tcgctgttga tcgcccagtt gatcgcccgt ttgcgcgaac
     9481 gactggaaag cgcccgtcgg catccgttcg atcgcctgct acgctgggcg ctcagccagc
     9541 cgacgccgcg cggcctggcc gaacgcctgc gcagcgcgcc ggaagagggc cgtgggccag
     9601 ccctggccgc ggcgcgcggc gtcgccccgg cgccggccgg catgtcgcgc gcaccgctcg
     9661 ccgagggcgc ggtggcgctc gacccgctgg tgcgcctggt gcccggcgag ggcgtgccgc
     9721 gggtgctggt ccacgaaggc ctcggcacgc tactgccgta ccgcccgctg cttcgcgccc
     9781 tgggtgaggg gcggccgttg ctggggctgg ccgtgcatga cagcgacgcc tacctggcga
     9841 tccccgccga gcatctcaac gcctgcctcg gccgccgcta cgccgaggcg ctccatcgcg
     9901 ccgggctacg cgaggtcgac ctgctcggct actgctccgg cgggctggtc gccctggaga
     9961 ccgccaagtc cctggtccag cgcggggtgc gcgtgcgcca actggatatc gtctccagct
    10021 accggattcc ctaccgggtg gacgacgagc gcctgctgtt gttcagcttc gccgcgaccc
    10081 tcggcctgga taccgcggcg ctcggcttcc ccgcgccgga acgtctcggc caggcggtgc
    10141 aggcggcgct cgcgcagaca ccggagcgcc tggtcgccga ggcgctggcg gggctgccgg
    10201 gcctggccga tctcgtcgcc ctgcgcggcc gcgtgctaca ggcggccagc ggtagcgccg
    10261 acgccgtcag cgtcgaacgc gacaccctct accggctgtt ctgtcactcg gtgcgtgcca
    10321 gccaggccga ggcgccggag ccctacgtcg gcgcgctgcg gctgttcgtg ccggacgccg
    10381 gcaacccatt ggtgccgcgc tacgccgagg ctctggagac ccaatggcgg gccgccgcgc
    10441 ttggcgcgtg cggcatccac gaggtgcccg gcgggcactt cgactgcctg ggcgaagccc
    10501 tggcgcaatc cttgtcgaaa cccatgccag aggaggcgag ccgatgagcg acgtccgttc
    10561 cgtggtggtc gccggttccc ggttcggcca gttctatgcc gccggcgtcg ccgccgatcc
    10621 gcgcttcgtc ctgcgcggca tccttggcca gggcagccgg cgttcgcggg cgttggccga
    10681 acgcctcggg gtggagacct ggtgcgaggt cgaggcgttg cccgacgatg tccgcctggc
    10741 ctgcgtcgcg gtcggcggcg cggcacgcgg cgagcagggc ccggcgctgg ccgaggcgct
    10801 gatggcgcgt ggcatcgacg tgctgatcga gcatccgttg ctgccgcgcg aatggcagga
    10861 cctgctgcgc agcgccgagc gcctgggccg gcgctgcctg ctcaacacct tctatccgca
    10921 gttgccggcg gtggcgcgtt tcatcgagct gggccgccag ttgcatcgcc ggcgcggcat
    10981 ccgccacctg gacgcggcct gcggggtgca ggtcggtttc gccaccctgg acatcctcgc
    11041 cgcgttgctg gagggcgttg gcccctggtc gctggagtcg ccctcgaacg acctgtcggc
    11101 gatgcgcggg ctgtccctgg tgttggcgga agtgccattg agcctgctcg tgctcaacga
    11161 actggcggcc gccgacgacg ggcgcatgac cttgttgcag cgcgtcagcc tgaccaccga
    11221 tcgcggcacg ctgagcctgc tcagccccca tggcccgttg ttgtggacgc ctgcggtggc
    11281 ggtaccggca gaggatgacg acggcctgtt cgcgctgttc gacgagatag ccggcgaacc
    11341 gctgcccagc gcccagctct ggtatgccga accgtgcagc tgggcccagg tgcaccagcg
    11401 cctgtggccg gcggcggcgg ccgaggcgct ggcgctgctc gccgacggcg acgaggtgcg
    11461 ccggcgcaac cagcgcagcc tggaggtcgc cgccctgtgg cagcggatcg gcgagcgcct
    11521 tggcttcccc gaggcgccgc cggcgtcgct ggcgccggcg agcctggaac aggtgctgga
    11581 gcaagcctcg tgaccccggt gctgtggcgc ctgctgcgca cctatcgctg gcggctggcg
    11641 gcggccatgg ggttgcaggc cctggccggg ctctgctcgc tgttgccctg gatgcttctc
    11701 gcctggctcg ccgagccgct ggcgcgcggc caggcgcagc cggccctgct ggccctggtg
    11761 ctgctggcgg tgctggcctg gctgggctgc caggcgctgg ccgcgcacct ggcccaccgg
    11821 gtcgacgcgg acctctgcaa cgacctgcgc ctgcgcctgc tggcgcacct gcaacggctg
    11881 ccgctggact ggttcggtcg ccagggcccg gacggcgtgg cgcgcctcgt ggagcaggac
    11941 gtgcgggccc tgcaccaact gatcgcgcac gctcccaacg atctcagcaa cctgttggtg
    12001 gtgccgctcg tcgcgttgct ctggctggcc tggctgcacc cctggctgct gctgttctgc
    12061 ctgctgccgc tggtgctggc cgccgccggc ttcctgctgc tgcgctcggc gcgctaccgc
    12121 gacctggtgc tgcggcgcaa cgccgcgctg gaaaggctct cggcggacta tggcgaattc
    12181 gcccacaacc tgctgctggc ccgacagtac cccggcgccg gcatacaaca gggcgccgag
    12241 gcgtcggcgg cggccttcgg cgaagcgttc ggcgcctggg tgaagcgggt cggccacctc
    12301 gccgcgctgg tctacgtgca gttgtcgacg ccctggctgc tggcctgggt cctgctcggc
    12361 gcgctggccc tggatgccct cggcgtgccg ctggcgctcg gccaggcctg tgccttcctg
    12421 ctcctgctgc gggccttggc tgccccggtg caggcgctcg gccacggcgg cgacgcgctg
    12481 ctgggcgcgc gcgccgccgc cgagcgcctg cagcaggtgt tcgaccaggc gccgctggcc
    12541 gagggccgct cgacccgcga gccggtcgat ggcgcggtgg cgctgcacgg cctgggccat
    12601 gcctatgaag gcgtggaggt cctggccgat atcgatctgg agctggagga tggcagcctg
    12661 gtggccctgg tcggtccctc gggctccggc aagagcaccc tgctgcacct gctggcgcgc
    12721 tacatggacg cgcagcgcgg cgaactggag gttggcggcc tggcactgaa ggacatgcct
    12781 gatgccgtgc gccatcggca tatcgcgctg gtcggccagc aggcggcggc gctggagata
    12841 tccctggccg acaacattgc cctgttccgc cccgatgccg atctccagga gattcgccag
    12901 gcggcccgtg acgcctgcct cgacgagcgc atcatggccc tgccgcgtgg ctacgacagc
    12961 gtgccgggac gcgacctgca actgtccggc ggcgaactgc aacgactggc cctggcccgt
    13021 gcgctgctat cgccggcgag cctgttgctg ctcgacgagc caacctcggc gctggatccg
    13081 cagaccgccc ggcaggtcct gcgcaacctg cgcgaacgcg gcggtggccg gacccgggtg
    13141 atcgtcgccc atcgtctggc cgaagtcagc gatgccgacc tgatcctggt gctggtcgct
    13201 ggccgtctgg tcgaacgcgg cgagcacgcg gcgctgttgg cggcggacgg cgcctatgcg
    13261 cgcttgtggc gtgaacagaa cggcgcggag gtggcggcat gaccctgttc gaacgaatgc
    13321 gtgcgctgcc cgaagactgc cgtgccgcgt tgcgccgggc gagcgcctgg gcggtcctgg
    13381 cggcgctgct ggacgccgct tgcggcgtat tgctggtgcc gttggtcgag gcctggttcg
    13441 ccgaaggcgc gttgccctgg cgctgggtcg ccgcgttgct cggcttgagc ctggcgcagg
    13501 cgctgttgca gtacctggcc ctgcgtcgcg gtttcgccgc cggcggctcg ctggcggctg
    13561 gactggtgcg cagcctggtg gcgcgcttgc cgcgcctggc gccgccggcg ctgcgccggg
    13621 tcgcgccggc cgaaggcctg ctgcgcggcc cggtgatgca ggcgatgggc attccggcgc
    13681 acctgctggg gccgctgatc gccgcgttgg tgacgccgct cggggtgatc ctcgggctgt
    13741 tcctgatcga cccgtccatc gccctcggcc tgctccttgc tggtgccttc ctcgccgcgc
    13801 tgttgcgctg gagcgggcgg cgcaatctgg cggcggagga tgcccggctg gccgccgagc
    13861 gcgacgccgc acggcagttg caggcgttcg ccgaacgcca gccactgctg cgcgcggcgc
    13921 agcgcgaaag cgtcgcccgc caggggctgg aagaggcctt gcgcagtctc caccgcagca
    13981 ccctggatct gttgcggcgc agcctgccca gcggcctcgg cttcgccctg gcggtgcagg
    14041 cggcgttcgc cttcgccctg ctcggcggcg cctgggcggt ggagcggcaa tggctggacg
    14101 gcgctcggct ggtggccgtg ctggtgctgc tggtgcgctt catcgagccg ctggcccagc
    14161 tcacccatct cgaccaggcg ttgcgcggcg cctggcaggc gctggatacc ctgctgcggg
    14221 ttttcgccct ggctccgctg cgcagccccg agccgggcga gcggccgcac gacgccagcc
    14281 tggcggccga ggccgtggaa ttgcgcctgg aagatggccg cgccttgctc gaggacattt
    14341 ccctgaggct ggagccgggt tcgctgaacg tcctcgtcgg accctccggg gccggcaaga
    14401 gcagcctgct ggcgctgctc gggcggctct acgacgtcga tgccgggcgt gtcctgctgg
    14461 gtggcgtgga tatccgccgg ttgagcgaaa cgaccctcgc cgccagtcgt aacctggtgt
    14521 tccaggacaa cggcctgttc cgcggcagcg ttgcctggaa cctgcgcatg gcgcgagcgg
    14581 acgccgatct cgaagcgctg cgcgaggcgg cgcgggcggt tggcctgctg gaagagatcg
    14641 aggcctggcc gcagggctgg gacagcgacg tcggtcccgg cggcgcgctg ctgtccggcg
    14701 gccagcggca acgcctgtgc ctggctcgcg ggctgctctc gacggcgccg ttgctgctgc
    14761 tcgacgagcc caccgccagc ctcgacgccg ccagcgaggc gcaggtgctg cgcagcctgc
    14821 tcgggttgcg cggccggcgc accctgctgg tattgaccca ccgcccggcg ctggcgcgtc
    14881 aggccgacca ggtactgctg ctggaggagg ggcgcctgcg cctcagcgga cttcacgccg
    14941 atctgctcgt ccgggacgac tggtatgccg gtttcgtcgg gctggcgggc gaggaaagtt
    15001 ccgcgacggt cgtggatcga tag
//
