BGC0000413: Pf-5 pyoverdine biosynthetic gene cluster from Pseudomonas protegens Pf-5
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Location: 4,702,146 - 4,877,199 nt. (total: 175,054 nt).
This entry is originally from NCBI GenBank CP000076.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000413
Short description Pf-5 pyoverdine biosynthetic gene cluster from Pseudomonas protegens Pf-5
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CP000076.1
Compounds
  • Pf-5 pyoverdine
Species Pseudomonas protegens Pf-5 [taxonomy]
References
Chemical products information
Pf-5 pyoverdine
Copy SMILES
C48H68N15O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PFL_4077
  • AAY93338.1
 4702146 - 4702862 (-) MgtC family protein
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  • PFL_4078
  • AAY93339.1
  • mgtA_2
 4703067 - 4705832 (-) magnesium-importing ATPase
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  • PFL_4079
  • AAY93340.1
  • pvdA
 4706381 - 4707718 (-) L-ornithine 5-monooxygenase PvdA
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  • PFL_4080
  • AAY93341.2
  • fpvI
 4707868 - 4708347 (-) RNA polymerase sigma-70 factor, ECF subfamily, FpvI
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  • PFL_4081
  • AAY93342.1
 4708677 - 4709849 (+) efflux transporter, RND family, MFP subunit
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  • PFL_4082
  • AAY93343.1
 4709850 - 4711823 (+) efflux ABC transporter, ATP-binding/permease protein
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  • PFL_4083
  • AAY93344.1
 4711831 - 4713222 (+) efflux transporter, outer membrane factor lipoprotein, NodT family
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  • PFL_4084
  • AAY93345.1
 4713323 - 4713622 (+) conserved hypothetical protein
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  • PFL_4085
  • AAY93346.1
 4713641 - 4714078 (+) conserved hypothetical protein
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  • PFL_4086
  • AAY93347.2
  • pvdP
 4714089 - 4715717 (-) chromophore maturation protein PvdP
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  • PFL_4087
  • AAY93348.2
  • pvdM
 4715925 - 4717298 (+) putative dipeptidase precursor
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  • PFL_4088
  • AAY93349.1
  • pvdN
 4717320 - 4718615 (+) chromophore maturation protein PvdN
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  • PFL_4089
  • AAY93350.1
  • pvdO
 4718663 - 4719556 (+) chromophore maturation protein PvdO
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  • PFL_4090
  • AAY93351.2
  • pvdF
 4719611 - 4720474 (-) N(5)-hydroxyornithine transformylase PvdF
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  • PFL_4091
  • AAY93352.1
  • pvdE
 4720675 - 4722327 (+) pyoverdine ABC transporter, permease/ATP-binding protein PvdE
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  • PFL_4092
  • AAY93353.1
  • fpvA
 4722429 - 4724897 (+) TonB-dependent outermembrane ferripyoverdine receptor FpvA
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  • PFL_4093
  • AAY93354.1
  • pvdD
 4725296 - 4738528 (-) non-ribosomal peptide synthetase PvdD
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  • PFL_4094
  • AAY93355.1
  • pvdJ
 4738541 - 4745122 (-) non-ribosomal peptide synthetase PvdJ
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  • PFL_4095
  • AAY93356.2
  • pvdI
 4745122 - 4756269 (-) non-ribosomal peptide synthetase PvdI
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  • PFL_4096
  • AAY93357.2
 4756482 - 4757450 (+) siderophore-interacting protein
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  • PFL_4097
  • AAY93358.1
 4757632 - 4758363 (-) thioesterase
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  • PFL_4098
  • AAY93359.1
 4758443 - 4759615 (-) transporter, major facilitator family
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  • PFL_4099
  • AAY93360.1
 4759751 - 4760338 (+) transcriptional regulator, TetR family
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  • PFL_4100
  • AAY93361.1
  • gdh
 4760451 - 4761251 (+) glucose 1-dehydrogenase
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  • PFL_4101
  • AAY93362.1
 4761244 - 4763070 (+) glycosyl hydrolase, family 15
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  • PFL_4102
  • AAY93363.1
 4763137 - 4763514 (+) conserved hypothetical protein
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  • PFL_4103
  • AAY93364.1
 4763511 - 4763972 (+) conserved hypothetical protein
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  • PFL_4104
  • AAY93365.1
 4764310 - 4765215 (+) alpha/beta hydrolase family protein
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  • PFL_4105
  • AAY93366.1
 4765217 - 4765765 (+) conserved hypothetical protein
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  • PFL_4106
  • AAY93367.1
 4765781 - 4767223 (+) NAD dependent epimerase/dehydratase family protein
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  • PFL_4107
  • AAY93368.1
 4767238 - 4769676 (+) conserved hypothetical protein
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  • PFL_4108
  • AAY93369.2
 4769686 - 4770669 (-) transcriptional regulator, AraC family
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  • PFL_4109
  • AAY93370.1
  • inhA
 4770762 - 4771448 (+) isonitrile hydratase InhA
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  • PFL_4110
  • AAY93371.1
 4771453 - 4771797 (-) conserved hypothetical protein
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  • PFL_4111
  • AAY93372.1
 4771822 - 4772454 (-) translocator protein, LysE family
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  • PFL_4112
  • AAY93373.1
 4772542 - 4773867 (+) transcriptional regulator, GntR family/aminotransferase, classes I and II family protein
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  • PFL_4113
  • AAY93374.2
  • str
 4774202 - 4775005 (-) streptomycin 3''-kinase
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  • PFL_4114
  • AAY93375.1
 4775084 - 4775542 (-) conserved hypothetical protein
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  • PFL_4115
  • AAY93376.1
 4775676 - 4776998 (+) ADP-ribosylglycohydrolase family protein
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  • PFL_4116
  • AAY93377.1
 4777036 - 4777437 (+) conserved hypothetical protein
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  • PFL_4117
  • AAY93378.1
  • peaD
 4777540 - 4778658 (-) quinohemoprotein amine dehydrogenase, beta subunit PeaD
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  • PFL_4118
  • AAY93379.2
  • peaC
 4778682 - 4779005 (-) quinohemoprotein amine dehydrogenase, gamma subunit PeaC
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  • PFL_4119
  • AAY93380.1
  • peaB
 4779007 - 4780440 (-) putative quinohemoprotein amine dehydrogenase modification protein PeaB
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  • PFL_4120
  • AAY93381.1
  • peaA
 4780520 - 4782100 (-) quinohemoprotein amine dehydrogenase, alpha subunit PeaA
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  • PFL_4121
  • AAY93382.1
 4782408 - 4784168 (+) KWG repeat protein
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  • PFL_4122
  • AAY93383.1
 4784270 - 4784935 (+) HAD hydrolase, family IA, variant 3
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  • PFL_4123
  • AAY93384.1
 4785323 - 4787038 (-) putative 2-isopropylmalate synthase
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  • PFL_4124
  • AAY93385.2
 4787314 - 4788144 (+) transcriptional regulator, AraC family
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  • PFL_4125
  • AAY93386.1
 4788149 - 4789738 (-) drug resistance transporter, EmrB/QacA family
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  • PFL_4126
  • AAY93387.1
 4789731 - 4790840 (-) auxiliary transport protein, membrane fusion protein family
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  • PFL_4127
  • AAY93388.1
 4790837 - 4792315 (-) efflux transporter, outer membrane factor lipoprotein, NodT family
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  • PFL_4128
  • AAY93389.1
 4792342 - 4792584 (-) conserved hypothetical protein
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  • PFL_4129
  • AAY93390.1
 4792570 - 4793130 (+) conserved hypothetical protein
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  • PFL_4130
  • AAY93391.1
  • peaE
 4793331 - 4794821 (+) phenylacetaldehyde dehydrogenase PeaE
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  • PFL_4131
  • AAY93392.1
 4795008 - 4796927 (+) amidohydrolase family protein
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  • PFL_4132
  • AAY93393.1
  • peaF
 4797065 - 4798384 (-) phenylethylamine degradation protein PeaF
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  • PFL_4133
  • AAY93394.1
 4798369 - 4799052 (-) conserved hypothetical protein
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  • PFL_4134
  • AAY93395.1
  • peaH
 4799042 - 4800760 (-) 2-phenylethylamine uptake protein PeaH
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  • PFL_4135
  • AAY93396.1
  • peaR
 4800760 - 4802664 (-) sigma-54 dependent transcriptional activator PeaR
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  • PFL_4136
  • AAY93397.1
  • aphA_2
 4803120 - 4804145 (-) acetylpolyamine aminohydrolase
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  • PFL_4137
  • AAY93398.2
 4804156 - 4805385 (-) N-carbamyl-L-amino acid amidohydrolase
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  • PFL_4138
  • AAY93399.1
 4805405 - 4806718 (-) transporter, major facilitator family
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  • PFL_4139
  • AAY93400.1
 4806897 - 4807862 (+) transcriptional regulator, LysR family
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  • PFL_4140
  • AAY93401.1
  • mrdA_1
 4807864 - 4809756 (-) penicillin-binding protein 2
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  • PFL_4146
  • AAY93402.2
 4815878 - 4816765 (+) integral membrane protein, DUF6 family
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  • PFL_4147
  • AAY93403.1
 4816924 - 4817205 (+) putative lipoprotein
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  • PFL_4148
  • AAY93404.1
 4817215 - 4817784 (-) transcriptional regulator, TetR family
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  • PFL_4149
  • AAY93405.1
 4817878 - 4818618 (+) short chain dehydrogenase/reductase family protein
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  • PFL_4150
  • AAY93406.1
 4818656 - 4819252 (+) DsbA-like thioredoxin domain protein
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  • PFL_4151
  • AAY93407.1
 4819337 - 4821145 (-) peptidase, M24 family
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  • PFL_4152
  • AAY93408.1
 4821201 - 4822370 (-) aminotransferase, class V
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  • PFL_4153
  • AAY93409.1
 4822581 - 4823195 (-) translocator protein, LysE family
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  • PFL_4154
  • AAY93410.1
 4823404 - 4823628 (-) putative lipoprotein
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  • PFL_4155
  • AAY93411.1
  • msuE
 4823959 - 4824522 (+) NADH-dependent FMN reductase
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  • PFL_4156
  • AAY93412.1
  • msuD
 4824532 - 4825671 (+) methanesulfonate sulfonatase MsuD
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  • PFL_4157
  • AAY93413.2
  • msuC
 4825806 - 4826993 (+) putative monooxygenase MsuC
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  • PFL_4158
  • AAY93414.1
 4827018 - 4828118 (+) sigma-54 dependent transcriptional regulator
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  • PFL_4159
  • AAY93415.1
 4828115 - 4828480 (-) antibiotic biosynthesis monooxygenase
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  • PFL_4160
  • AAY93416.1
  • soxR
 4828589 - 4829062 (+) redox-sensitive transcriptional activator SoxR
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  • PFL_4162
  • AAY93418.1
 4831091 - 4831735 (+) organic radical activating enzyme family protein
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  • PFL_4163
  • AAY93419.1
 4831751 - 4838068 (+) histidine kinase
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  • PFL_4164
  • AAY93420.1
 4838065 - 4839399 (+) conserved hypothetical protein
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  • PFL_4165
  • AAY93421.1
 4839497 - 4840267 (-) lipoprotein, NLPA family
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  • PFL_4166
  • AAY93422.1
 4840350 - 4841015 (-) putative ABC transporter, permease protein
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  • PFL_4167
  • AAY93423.1
 4841019 - 4842311 (-) monooxygenase, DszC family
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  • PFL_4168
  • AAY93424.1
 4842526 - 4842993 (+) glyoxalase family protein
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  • PFL_4169
  • AAY93425.1
 4843290 - 4844513 (+) PepSY-associated TM helix domain protein
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  • PFL_4170
  • AAY93426.1
 4844510 - 4845052 (+) conserved hypothetical protein
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  • PFL_4171
  • AAY93427.1
 4845049 - 4845387 (+) conserved hypothetical protein
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  • PFL_4172
  • AAY93428.1
 4845384 - 4845956 (+) conserved hypothetical protein
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  • PFL_4173
  • AAY93429.2
 4845992 - 4846921 (+) cation ABC transporter, MZT family, periplasmic cation-binding protein
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  • PFL_4174
  • AAY93430.1
 4846918 - 4847661 (+) cation ABC transporter, MZT family, ATP-binding protein
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  • PFL_4175
  • AAY93431.1
 4847661 - 4848560 (+) cation ABC transporter, MZT family, permease protein
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  • PFL_4176
  • AAY93432.1
 4848561 - 4849544 (+) conserved hypothetical protein
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  • PFL_4177
  • AAY93433.1
 4849756 - 4850583 (+) methyltransferase domain protein
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  • PFL_4178
  • AAY93434.1
 4850873 - 4851097 (-) MbtH-like protein
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  • PFL_4179
  • AAY93435.2
  • pvdH
 4851180 - 4852592 (-) 2,4-diaminobutyrate 4-transaminase
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  • PFL_4180
  • AAY93436.1
 4852828 - 4854153 (-) sensor histidine kinase
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  • PFL_4181
  • AAY93437.1
 4854154 - 4854831 (-) DNA-binding response regulator
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  • PFL_4182
  • AAY93438.1
  • dsbD
 4854985 - 4856736 (+) thiol:disulfide interchange protein DsbD
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  • PFL_4183
  • AAY93439.1
 4856736 - 4857599 (+) antioxidant, AhpC family
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  • PFL_4184
  • AAY93440.1
  • dsbG
 4857575 - 4858342 (+) thiol:disulfide interchange protein DsbG
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  • PFL_4185
  • AAY93441.1
 4858556 - 4859368 (-) alpha/beta hydrolase family protein
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  • PFL_4186
  • AAY93442.1
 4859477 - 4860100 (-) conserved hypothetical protein
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  • PFL_4187
  • AAY93443.1
 4860392 - 4861441 (-) conserved hypothetical protein
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  • PFL_4188
  • AAY93444.1
 4861561 - 4862811 (-) conserved hypothetical protein
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  • PFL_4189
  • AAY93445.1
  • pvdL
 4862826 - 4875854 (-) non-ribosomal peptide synthetase PvdL
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  • PFL_4190
  • AAY93446.1
  • pvdS
 4876228 - 4876776 (+) RNA polymerase sigma-70 factor, ECF subfamily, PvdS
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  • PFL_4191
  • AAY93447.1
  • pvdY
 4876810 - 4877199 (-) pyoverdine biosynthesis protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
pvdD
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: N5-formyl-N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
pvdJ
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
pvdI
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: N5-formyl-N5-hydroxyornithine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
pvdL
Module ?
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Changed chemical structures for compounds: Pf-5 pyoverdine.
  • Renamed compounds: pyoverdin to Pf-5 pyoverdine.
  • Updated NPAtlas ID for compounds: Pf-5 pyoverdine.
Detailed domain annotation
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