BGC0000414: quinocarcin biosynthetic gene cluster from Streptomyces melanovinaceus
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Location: 1 - 48,769 nt. (total: 48,769 nt).
This entry is originally from NCBI GenBank AB819321.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000414
Short description quinocarcin biosynthetic gene cluster from Streptomyces melanovinaceus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AB819321.1
Compounds
  • quinocarcin
Species Streptomyces melanovinaceus [taxonomy]
References
Chemical products information
quinocarcin
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C18H22N2O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAO84850.1
  • qcn1
 5399 - 6877 (+) putative peptidase
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  • BAO84851.1
  • qcn2
 6934 - 9675 (+) putative dehydrogenase
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  • BAO84852.1
  • qcn3
 9672 - 10619 (+) putative molybdopterin dehydrogenase, FAD-binding protein
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  • BAO84853.1
  • qcn4
 10648 - 11526 (-) putative monooxygenase
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  • BAO84854.1
  • qcn5
 11612 - 12241 (-) putative methyltransferase
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  • BAO84855.1
  • qcn6
 12438 - 15032 (+) putative UV-repair protein
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  • BAO84856.1
  • qcn7
 15148 - 16092 (+) putative dehydrogenase alpha subunit
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  • BAO84857.1
  • qcn8
 16089 - 16319 (+) putative phosphopantetheine binding protein
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  • BAO84858.1
  • qcn9
 16316 - 18499 (+) putative dehydrogenase beta subunit
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  • BAO84859.1
  • qcn10
 18539 - 19573 (+) 3-oxoacyl-(acyl-carrier-protein (acp)) synthase III domain-containing protein
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  • BAO84860.1
  • qcn11
 19652 - 20389 (-) putative N-methyltransferase
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  • BAO84861.1
  • qcn12
 20420 - 23668 (-) putative non-ribosomal peptide synthetase
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  • BAO84862.1
  • qcn13
 23719 - 25923 (-) putative long-chain-fatty-acid-CoA ligase
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  • BAO84863.1
  • qcn14
 26193 - 26987 (+) thioesterase domain-containing protein
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  • BAO84864.1
  • qcn15
 26984 - 30355 (+) putative non-ribosomal peptide synthetase
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  • BAO84865.1
  • qcn16
 30437 - 30646 (+) putative MbtH like protein
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  • BAO84866.1
  • qcn17
 30796 - 35256 (+) putative non-ribosomal peptide synthetase
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  • BAO84867.1
  • qcn18
 35338 - 36372 (+) putative dioxygenase
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  • BAO84868.1
  • qcn19
 36462 - 39179 (+) putative non-ribosomal peptide synthetase
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  • BAO84869.1
  • qcn20
 39261 - 40133 (-) AfsR/DnrI/RedD family transcriptional regulator
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  • BAO84870.1
  • qcn21
 40398 - 40925 (+) putative regulator component
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  • BAO84871.1
  • qcn22
 40987 - 41505 (+) putative regulator component
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  • BAO84872.1
  • qcn23
 41495 - 42739 (+) putative regulator component
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  • BAO84873.1
  • qcn24
 42787 - 44076 (+) major facilitator transporter
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
qcn12
Module ?
Specificity: alanine
Evidence for specificity:
qcn15
Module ?
Specificity: glycolic acid
Evidence for specificity:
qcn17
Module ?
Specificity: 4,5-dehydroarginine
Evidence for specificity:
  • ATP-PPi exchange assay
qcn19
Module ?
Specificity: meta-tyrosine / 3-hydroxy-O-methyl-5-methyltyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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