BGC0000414: quinocarcin biosynthetic gene cluster from Streptomyces melanovinaceus
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Location: 1 - 48,769 nt. (total: 48,769 nt).
This entry is originally from NCBI GenBank AB819321.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000414
Short description quinocarcin biosynthetic gene cluster from Streptomyces melanovinaceus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AB819321.1
via
Compounds
  • quinocarcin
Species Streptomyces melanovinaceus [taxonomy]
References
Chemical products information
quinocarcin Evidence:
Copy SMILES
C18H22N2O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAO84850.1
  • qcn1
 5399 - 6877 (+) putative peptidase
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    • BAO84851.1
    • qcn2
    		 6934 - 9675 (+) putative dehydrogenase
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      • BAO84852.1
      • qcn3
      		 9672 - 10619 (+) putative molybdopterin dehydrogenase, FAD-binding protein
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        • BAO84853.1
        • qcn4
        		 10648 - 11526 (-) putative monooxygenase
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          • BAO84854.1
          • qcn5
          		 11612 - 12241 (-) putative methyltransferase
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            • BAO84855.1
            • qcn6
            		 12438 - 15032 (+) putative UV-repair protein
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              • BAO84856.1
              • qcn7
              		 15148 - 16092 (+) putative dehydrogenase alpha subunit
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                • BAO84857.1
                • qcn8
                		 16089 - 16319 (+) putative phosphopantetheine binding protein
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                  • BAO84858.1
                  • qcn9
                  		 16316 - 18499 (+) putative dehydrogenase beta subunit
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                    • BAO84859.1
                    • qcn10
                    		 18539 - 19573 (+) 3-oxoacyl-(acyl-carrier-protein (acp)) synthase III domain-containing protein
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                      • BAO84860.1
                      • qcn11
                      		 19652 - 20389 (-) putative N-methyltransferase
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                        • BAO84861.1
                        • qcn12
                        		 20420 - 23668 (-) putative non-ribosomal peptide synthetase
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                          • BAO84862.1
                          • qcn13
                          		 23719 - 25923 (-) putative long-chain-fatty-acid-CoA ligase
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                            • BAO84863.1
                            • qcn14
                            		 26193 - 26987 (+) thioesterase domain-containing protein
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                              • BAO84864.1
                              • qcn15
                              		 26984 - 30355 (+) putative non-ribosomal peptide synthetase
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                                • BAO84865.1
                                • qcn16
                                		 30437 - 30646 (+) putative MbtH like protein
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                                  • BAO84866.1
                                  • qcn17
                                  		 30796 - 35256 (+) putative non-ribosomal peptide synthetase
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                                    • BAO84867.1
                                    • qcn18
                                    		 35338 - 36372 (+) putative dioxygenase
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                                      • BAO84868.1
                                      • qcn19
                                      		 36462 - 39179 (+) putative non-ribosomal peptide synthetase
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                                        • BAO84869.1
                                        • qcn20
                                        		 39261 - 40133 (-) AfsR/DnrI/RedD family transcriptional regulator
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                                          • BAO84870.1
                                          • qcn21
                                          		 40398 - 40925 (+) putative regulator component
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                                            • BAO84871.1
                                            • qcn22
                                            		 40987 - 41505 (+) putative regulator component
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                                              • BAO84872.1
                                              • qcn23
                                              		 41495 - 42739 (+) putative regulator component
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                                                • BAO84873.1
                                                • qcn24
                                                		 42787 - 44076 (+) major facilitator transporter
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  Unk01
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  qcn12
                                                  Substrates
                                                  alanine (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk02
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  qcn15
                                                  Substrates
                                                  glycolic acid (evidence: )
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk03
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  qcn17
                                                  Substrates
                                                  4,5-dehydroarginine (evidence: ATP-PPi exchange assay [1])
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Name
                                                  Unk04
                                                  Type
                                                  nrps-type1
                                                  Genes
                                                  qcn19
                                                  Substrates
                                                  meta-tyrosine, 3-hydroxy-O-methyl-5-methyltyrosine (evidence: ATP-PPi exchange assay [1])
                                                  Integrated Monomers
                                                  Domains
                                                  adenylation
                                                  Annotation changelog

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Added NRP substrate specificities
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-06-12
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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