BGC0000416 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000416 (Xenorhabdus nematophila ATCC 19061)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	55,337	Low	nematophin	NRPS:Type I

BGC0000416 - Region 1 - NRPS

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Location: 1 - 55,337 nt. (total: 55,337 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 55,338
Label		BGC0000416

Tailoring functions

Ligases: ligase

XNC1_2228: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

XNC1_2229: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

XNC1_2230: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000416.5	0.97	NRPS	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001692.5	0.83	NRPS	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0001434.3	0.72	NRPS	nematophin	Xenorhabdus budapestensis
BGC0002713.2	0.70	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.67	NRPS	AbT1	Aureobasidium pullulans
BGC0000465.4	0.65	NRPS	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001249.5	0.63	NRPS	dimethylcoprogen	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000416.5	0.97	NRPS	rhabdopeptide 1, rhabdopeptide 2, rhabdopeptide 3, rhabdopeptide 4	Xenorhabdus nematophila ATCC 19061
BGC0001692.5	0.83	NRPS	nematophin	Xenorhabdus nematophila ATCC 19061
BGC0001434.3	0.72	NRPS	nematophin	Xenorhabdus budapestensis
BGC0002713.2	0.70	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.67	NRPS	AbT1	Aureobasidium pullulans
BGC0000465.4	0.65	NRPS	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.65	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001249.5	0.63	NRPS	dimethylcoprogen	Alternaria alternata

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 55337:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Leu) + (NMe-Val) + (NMe-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

XNC1_2228: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (549..944): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Leu DALVLAVSIK (100% 8Å match); Val DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_2229: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (545..941): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

XNC1_2230: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (549..945): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALVLAVSIK
Nearest Stachelhaus code(s):: Val DALVLAVSIK (100% 8Å match); Leu DALVLAVSIK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor