BGC0000416: rhabdopeptide 1 biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
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Location: 2,154,724 - 2,170,060 nt. (total: 15,337 nt).
This entry is originally from NCBI GenBank FN667742.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000416
Short description rhabdopeptide 1 biosynthetic gene cluster from Xenorhabdus nematophila ATCC 19061
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Overlaps, and possibly shares genes with nematophin (BGC0001692)."
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FN667742.1
2154724 - 2170060
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • rhabdopeptide 1
  • rhabdopeptide 2
  • rhabdopeptide 3
  • rhabdopeptide 4
Species Xenorhabdus nematophila ATCC 19061 [taxonomy]
References
Chemical products information
rhabdopeptide 1 Evidence:
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C32H55N5O4
rhabdopeptide 2 Evidence:
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C33H57N5O4
rhabdopeptide 3 Evidence:
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C38H66N6O5
rhabdopeptide 4 Evidence:
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C39H68N6O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNC1_2228
  • CBJ90287.1
 2154724 - 2159406 (+) peptide synthetase
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    • XNC1_2229
    • CBJ90288.1
    		 2159403 - 2164067 (+) Peptide synthetase
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      • XNC1_2230
      • CBJ90289.1
      		 2164064 - 2170060 (+) peptide synthetase
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        Biosynthesis information

        Biosynthetic modules

        Name
        1
        Type
        nrps-type1
        Genes
        XNC1_2228
        Substrates
        leucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation, methyltransferase
        Name
        2
        Type
        nrps-type1
        Genes
        XNC1_2229
        Substrates
        valine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation, methyltransferase
        Name
        3
        Type
        nrps-type1
        Genes
        XNC1_2230
        Substrates
        valine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation, methyltransferase
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-10-07
        Add note about possible overlap with BGC0001692
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Corrected NRP module activity
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Changed amino acid substrates to lower case
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2015-06-12
        Submitted
        • (ID: SCFYH7235HZBUM2XBV52IUHT)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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