Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000416.1:
Cluster 1NRP115337

BGC0000416, rhabdopeptides biosynthetic gene cluster from Xenorhabdus nematophila. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Rhabdopeptide 1
SMILES string: Copy to clipboard
Molecular formula: C32H56N5O4
Exact molecular mass: 574.432682 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
None
Release / cyclization type:
Other

Nonribosomal peptide synthetases:
CBJ90287.1
Module 1
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
CBJ90288.1
Module 2
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module is iterated
Evidence for iteration: Unknown
CBJ90289.1
Module 3
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 4
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL

Gene cluster description

rhabdopeptides (BGC0000416). Gene Cluster 1. Biosynthetic class = NRP. GenBank FN667742, positions 2154724-2170060. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Helge B. Bode (Molecular Biotechnology, Institute for Molecular Bioscience, Goethe University Frankfurt, 60438 Frankfurt/Main, Germany)

Literature references

1. Reimer D et al. (2013) Rhabdopeptides as insect-specific virulence factors from entomopathogenic bacteria. Chembiochem 14(15):1991-7. doi: 10.1002/cbic.201300205. Epub 2013