BGC0000418: Ristocetin A biosynthetic gene cluster from Amycolatopsis lurida
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Location: 1 - 80,193 nt. (total: 80,193 nt).
This entry is originally from NCBI GenBank KJ364518.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000418
Short description Ristocetin A biosynthetic gene cluster from Amycolatopsis lurida
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KJ364518.1
via
Compounds
  • Ristocetin A
  • Desmethyl ristocetin A
  • Ristocetin B
  • Desmethyl ristocetin B
Species Amycolatopsis lurida [taxonomy]
References
Chemical products information
Ristocetin A [synonyms: Ristomycin A] Evidence: NMR [1], [2], [3]
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C95H110N8O44
Chemical database entries
PubCHEM
NPAtlas
Desmethyl ristocetin A Evidence: Mass spectrometry [4]
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C94H108N8O44
Ristocetin B Evidence: Mass spectrometry [4]
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C84H92N8O35
Chemical database entries
PubCHEM
Desmethyl ristocetin B Evidence: Mass spectrometry [4]
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C83H90N8O35
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIE77051.1
 2314 - 3345 (+) VanH
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    • AIE77052.1
    		 3347 - 4387 (+) VanA
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      • AIE77053.1
      		 4384 - 4992 (+) VanX
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        • AIE77054.1
        		 6334 - 7125 (+) StrR family transcriptional regulator
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          • AIE77055.1
          		 7246 - 8097 (+) prephenate dehydrogenase
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            • AIE77056.1
            		 8410 - 10272 (+) ABC-transporter
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              • AIE77057.1
              		 10275 - 16457 (+) peptide synthetase
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                • AIE77058.1
                		 16454 - 19603 (+) peptide synthetase module 3
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                  • AIE77059.1
                  		 19978 - 31968 (+) peptide synthetase
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                    • AIE77060.1
                    		 32056 - 37617 (+) peptide synthetase module 7
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                      • AIE77061.1
                      		 37632 - 37841 (+) putative MbtH protein
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                        • AIE77062.1
                        		 38059 - 39234 (+) OxyA monooxygenase
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                          • AIE77063.1
                          		 39258 - 40415 (+) p450 monooxygenase-like protein
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                            • AIE77064.1
                            		 40405 - 41601 (+) p450 monooxygenase-like protein
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                              • AIE77065.1
                              		 41929 - 43170 (+) p450 monooxygenase-like protein
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                                • AIE77066.1
                                		 43183 - 44340 (+) glycosyltransferase
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                                  • AIE77067.1
                                  		 44371 - 45579 (+) glycosyltransferase
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                                    • AIE77068.1
                                    		 45601 - 46809 (+) glycosyltransferase
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                                      • AIE77069.1
                                      		 46836 - 47648 (+) methyltransferase
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                                        • AIE77070.1
                                        		 47669 - 48796 (+) glycosyltransferase
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                                          • AIE77071.1
                                          		 48907 - 49737 (+) hypothetical protein
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                                            • AIE77072.1
                                            		 49808 - 51535 (+) mannosyltransferase
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                                              • AIE77073.1
                                              		 51599 - 52639 (+) methyltransferase
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                                                • AIE77074.1
                                                		 52817 - 54103 (-) phenylglycine amino transferase
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                                                  • AIE77075.1
                                                  		 54274 - 55104 (+) alpha/beta hydrolase
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                                                    • AIE77076.1
                                                    		 55101 - 56837 (+) peptide synthetase
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                                                      • AIE77077.1
                                                      		 56852 - 58042 (+) p450 monooxygenase
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                                                        • AIE77078.1
                                                        		 58145 - 59206 (+) 4-hydroxyphenylpyruvate dioxygenase
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                                                          • AIE77079.1
                                                          		 59203 - 60273 (+) putative phenylglycolate oxidase
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                                                            • AIE77080.1
                                                            		 60279 - 61688 (+) putative NDP-hexose 2,3-dehydratase
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                                                              • AIE77081.1
                                                              		 61690 - 62655 (+) NAD-dependent epimerase dehydratase
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                                                                • AIE77082.1
                                                                		 62652 - 63761 (+) putative C-3 aminotransferase
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                                                                  • AIE77083.1
                                                                  		 63778 - 64395 (+) putative 3,5 epimerase
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                                                                    • AIE77084.1
                                                                    		 64592 - 66295 (+) mannosyltransferase
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                                                                      • AIE77085.1
                                                                      		 66547 - 67647 (+) dihydroxyphenylacetic acid synthase-like protein
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                                                                        • AIE77086.1
                                                                        		 67641 - 68303 (+) enoyl-CoA hydratase
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                                                                          • AIE77087.1
                                                                          		 68300 - 69517 (+) enoyl-CoA hydratase-like protein
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                                                                            • AIE77088.1
                                                                            		 69514 - 70311 (+) enoyl-CoA hydratase-like protein
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                                                                              • AIE77089.1
                                                                              		 70483 - 71565 (+) putative aldolase
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                                                                                Biosynthesis information

                                                                                Biosynthetic modules

                                                                                Name
                                                                                Unk01
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77057.1
                                                                                Substrates
                                                                                4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk02
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77057.1
                                                                                Substrates
                                                                                R-beta-hydroxytyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk03
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77058.1
                                                                                Substrates
                                                                                3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk04
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77059.1
                                                                                Substrates
                                                                                4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk05
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77059.1
                                                                                Substrates
                                                                                4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk06
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77059.1
                                                                                Substrates
                                                                                R-beta-hydroxytyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk07
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77060.1
                                                                                Substrates
                                                                                3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk08
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                AIE77076.1
                                                                                Substrates
                                                                                tyrosine (evidence: Homology [4])
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Annotation changelog

                                                                                Entry version: next

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2024-04-24
                                                                                MIBiG v4 annotathon
                                                                                • (ID: D4PT7DYQL5DZKSW73RASEGB6)
                                                                                • (ID: TVYWRCMOBR5VOOLSE2IIZG7H)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 4

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2022-10-07
                                                                                Update chemical activity to schema version 2.11
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 3

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2022-09-15
                                                                                Updated bioactivity data
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                2022-09-15
                                                                                Added NRP substrate specificities
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 2

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2019-10-16
                                                                                Migrated from v1.4
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 1

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2015-06-12
                                                                                Submitted
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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