BGC0000420 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000420 (Penicillium rubens Wisconsin 54-1255)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	20,659	histidyltryptophanyldiketopiperazine/dehydrohistidyltryptophanyldiketopiperazine/roquefortine D/roquefortine C/glandicoline A/glandicoline B/meleagrine	NRPS:Type I	100%

BGC0000420 - Region 1 - NRPS,indole

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Location: 1 - 20,659 nt. (total: 20,659 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,660
Label		BGC0000420

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000420	1.45	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0002736	0.61	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0001989	0.61	Other	pulcherrimin	Kluyveromyces lactis
BGC0001777	0.51	Terpene	shearinine D	Escovopsis weberi
BGC0002226	0.51	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0000811	0.41	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0001260	0.39	Terpene	terpendole E	Tolypocladium album
BGC0001267	0.38	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0000688	0.38	Terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001082	0.38	Terpene	paxilline, paspaline, 13-dehydroxypaxilline, paspaline B	Penicillium paxilli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000420	1.00	NRP	histidyltryptophanyldiketopiperazine, dehydrohistidyltryptophanyldiketopiperazine, roquefortine D, roquefortine C, glandicoline A, glandicoline B, meleagrine	Penicillium rubens Wisconsin 54-1255
BGC0002226	0.71	NRP	acu-dioxomorpholine B, acu-dioxomorpholine A	Aspergillus aculeatus ATCC 16872
BGC0002157	0.67	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0002736	0.64	Terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0001989	0.64	Other	pulcherrimin	Kluyveromyces lactis
BGC0002710	0.64	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0001261	0.62	NRP	AM-toxin	Alternaria alternata
BGC0002248	0.62	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 20659:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp - His)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PCH_Pc21g15480

Search NORINE for peptide: strict or relaxed

AMP-binding (216..610): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSLELVAVVK
Nearest Stachelhaus code(s):: Trp DSLELVAVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1288..1679): His

nrpys: His

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DIAMIGSMYK
Nearest Stachelhaus code(s):: His DIAMIGSMYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)