LOCUS       BGC0000420             20659 bp    DNA     linear   PLN 27-FEB-2015
DEFINITION  Penicillium chrysogenum Wisconsin 54-1255 complete genome, contig
            Pc00c21.
ACCESSION   BGC0000420
VERSION     BGC0000420
KEYWORDS    .
SOURCE      Penicillium rubens Wisconsin 54-1255
  ORGANISM  Penicillium rubens Wisconsin 54-1255
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium; Penicillium chrysogenum species complex.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 19:10:36
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..20659
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[13201:20659]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      13202..20659
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..20659
                     /SMILES="NC([*])C(=O)N1C(CCC1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..20659
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000420"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20659
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="indole"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..13978
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2639:3978]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      2640..3978
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    1..13978
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     exon            1..153
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=1
     mRNA            join(<1..153,224..603,657..1083,1133..>1792)
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
     gene            <1..>1792
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
     CDS             join(1..153,224..603,657..1083,1133..1792)
                     /codon_start=1
                     /db_xref="GOA:B6HJU0"
                     /db_xref="InterPro:IPR005829"
                     /db_xref="InterPro:IPR011701"
                     /db_xref="InterPro:IPR016196"
                     /db_xref="InterPro:IPR020846"
                     /db_xref="UniProtKB/TrEMBL:B6HJU0"
                     /gene="Pc21g15420"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 387.6; E-value:
                     9.8e-118)"
                     /gene_kind="transport"
                     /inference="protein motif:COGS:COG0477"
                     /inference="similar to AA sequence:TREMBL:AF091042.1"
                     /locus_tag="PCH_Pc21g15420"
                     /note="Title: strong similarity to cercosporin transporter
                     CFP - Cercospora kikuchii"
                     /product="Transporter"
                     /protein_id="CAP96439.1"
                     /transl_table=1
                     /translation="MEKEVATDPLPQEIPSDAPDEGGSLSRPAANTWTVVSLTIALCLG
                     VFCMSLDVTIITTAIPRITDQFDSLDDIGWYGSSYLLTNCATTLAFGKFYTFYSTKWVY
                     LSALFLFEVGSLVCGVTPTSVGLILGRCIAGLGAGGLFSGSLLIIAQTVPLHRRPVFTA
                     LLGSMYGIASVAGPPLGGALTDRVSWRWCFYINLPIGAVTAAFVLFFFHAPNSVKRRPE
                     LRKLLSELDPIGSFFFLPAIVCLLLALQWGGTQYSWKSPRIIVLFVLTGVLLLAFVAVQ
                     IRQNEKATLPPRIVQNRNIWSSAWFAITLNGAYFVFIYYLPIWFQAIKAASATKSGVMN
                     LPSIIAVVVVSIISGMLVTIFGYYNPVMIMSSVTLSIGAGLLSTLKTDSGSGEWIGYQI
                     LMGLGVGLGMQQPFMVVQNVLPDGDVPTGTAVITFAQTLGGAIFISVGQNIFQNQFAHT
                     MHLEDPSVNVATVLSAGTTTLRKYLPAEQLPAVLRSYNTAITQAFYVGVALASLSCIGT
                     IALEWKSVKKPRNTTPNDHSGS"
     intron          154..223
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=1
     exon            224..603
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=2
     intron          604..656
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=2
     exon            657..1083
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=3
     intron          1084..1132
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=3
     exon            1133..1792
                     /gene="Pc21g15420"
                     /locus_tag="PCH_Pc21g15420"
                     /number=4
     exon            2640..3808
                     /gene="Pc21g15430"
                     /locus_tag="PCH_Pc21g15430"
                     /number=1
     mRNA            join(<2640..3808,3879..>3978)
                     /gene="Pc21g15430"
                     /locus_tag="PCH_Pc21g15430"
     gene            <2640..>3978
                     /gene="Pc21g15430"
                     /locus_tag="PCH_Pc21g15430"
     CDS             join(2640..3808,3879..3978)
                     /codon_start=1
                     /db_xref="GOA:B6HJU1"
                     /db_xref="InterPro:IPR012148"
                     /db_xref="InterPro:IPR017795"
                     /db_xref="UniProtKB/TrEMBL:B6HJU1"
                     /gene="Pc21g15430"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /inference="similar to AA sequence:TREMBLNEW:AY259840.1"
                     /locus_tag="PCH_Pc21g15430"
                     /note="unknown EC_number=2.5.1.34; Title: strong similarity
                     to dimethylallyltryptophan synthase dmaW - Claviceps
                     purpurea"
                     /product="dimethylallyltryptophan synthase"
                     /protein_id="CAP96440.1"
                     /sec_met_domain="dmat (E-value: 8.6e-119, bitscore: 386.1,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTVSSTVQPLKACVPEATEAADMPHHTLSKSMTFANLDQYQYWHA
                     VGPMLGRMLSNGSYSIHKQYEYLCLFAHVIIPKLGPFPGGRDIYKCLLGGTGSVELSQN
                     VQKLGLTARVAFEPTSYIASTGVDPLNRHTVHATLVELRAIGSASIDMELHQMLVNELT
                     LTDREERLMSPEAISGTAWKTQILLALDLGQTGITIKEYFYPALKASVTGQSVAKLCFS
                     AIRKVDKQGRFEPASKAIETYMKTQSQTDLYFLSCDLVDPAATRIKLYLMELDMRLAKV
                     EEHWTMGGKLNDEETLLGLKMLQELWVEFGIIEGMRNEPERPSLPGDPDTIVPFIMNYE
                     MSPGEALPKPKFYFPLVGIPELKIANVLTAFFERYGMPEQAAVYRNNLQTPSKDLVIAT
                     DHQAWLSFSYTKKKGPYLTMYYH"
     intron          3809..3878
                     /gene="Pc21g15430"
                     /locus_tag="PCH_Pc21g15430"
                     /number=1
     exon            3879..3978
                     /gene="Pc21g15430"
                     /locus_tag="PCH_Pc21g15430"
                     /number=2
     exon            complement(4335..4723)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=1
     mRNA            complement(join(<4335..4723,4769..4825,4881..4919,
                     4986..>5367))
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
     gene            complement(<4335..>5367)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
     CDS             complement(join(4335..4723,4769..4825,4881..4919,
                     4986..5367))
                     /codon_start=1
                     /db_xref="GOA:B6HJU2"
                     /db_xref="InterPro:IPR013216"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/TrEMBL:B6HJU2"
                     /gene="Pc21g15440"
                     /inference="protein motif:COGS:COG0500"
                     /inference="protein motif:COGS:COG2226"
                     /inference="protein motif:COGS:COG4106"
                     /inference="similar to AA sequence:PIR:E87682"
                     /locus_tag="PCH_Pc21g15440"
                     /note="Title: weak similarity to hypothetical UbiE/COQ5
                     family methlytransferase - Caulobacter crescentus"
                     /product="methyltransferase"
                     /protein_id="CAP96441.1"
                     /transl_table=1
                     /translation="MTRATNFTELYAGKGILDTYMVAEKITRYYTQDLIQLSGLSESSL
                     TPLVILDLACGTGVVSDALHDMLNFQPKGNWELTCGDISTELTGHVKQKILERGWENSI
                     AKVVDAQNTELPTGHYTHVFAALAFTSFPDTYAAMKEVMRILQPGGTLTISTWQRTEWL
                     AVVEAAVAIIPADLPFPTTKEFMSCMNPGWDSEDYVHSRFEEAGFHSVQVTTISKQFET
                     SVEDLYKIAQPVIPIIVSKWWNQEQRDKYENDILPALQRHLNETYGENGLVPQEWTAVF
                     ATGQKGS"
     intron          complement(4724..4768)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=1
     exon            complement(4769..4825)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=2
     intron          complement(4826..4880)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=2
     exon            complement(4881..4919)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=3
     intron          complement(4920..4985)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=3
     exon            complement(4986..5367)
                     /gene="Pc21g15440"
                     /locus_tag="PCH_Pc21g15440"
                     /number=4
     exon            5950..6159
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=1
     mRNA            join(<5950..6159,6225..6341,6407..6506,6564..6632,
                     6689..7282,7381..>7802)
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
     gene            <5950..>7802
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
     CDS             join(5950..6159,6225..6341,6407..6506,6564..6632,
                     6689..7282,7381..7802)
                     /codon_start=1
                     /db_xref="GOA:B6HJU3"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002403"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="UniProtKB/TrEMBL:B6HJU3"
                     /gene="Pc21g15450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 136.7; E-value: 1.8e-41)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:COGS:COG2124"
                     /inference="protein motif:PFAM:PF00067"
                     /inference="similar to AA sequence:TREMBL:GFP450I.1"
                     /locus_tag="PCH_Pc21g15450"
                     /note="Title: strong similarity to cytochrome P450
                     monooxygenase P450I - Gibberella fujikuroi"
                     /product="P450 monooxygenase"
                     /protein_id="CAP96442.1"
                     /sec_met_domain="p450 (E-value: 1.2e-42, bitscore: 135.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDVVARFMVSYSGTACAISLFIFGITLLFPFHKSQSFVCMNSHSW
                     DIFRNKAKREFESNAEKLIKDALRKGLTAFQLVTNMGTYLILADQYAEELRNDKRLSAY
                     DALNDVILLELPGLETMFQGSLHNHVSPTAIHAMNRELVHLTRALSDEANHRLQTQWTD
                     SSEWHTVSIHDTVLALVAQMTTRAFVGAELCRNAEWLDIAINFTINRAIAVQAVQAWPW
                     ILQPVVHWFLPTCKAVRRQIQRARTILMPVLERERQTMHRKDSSSDRIFSTLTFIDQYA
                     QGSRYDATMAQLRLTAVSVLTTSDMVEKVLARICEHPELIQPLREEVVSVFESSGLHHK
                     SLLKLTLMESVMKESQRLEPATLISMFRAAKKTVTLQDGTTIPKGTRLAFANDLRLDPE
                     LYPDPETFDGYRFERMRKDPEQAKLAPFTKTRTSHLAFGHGKHACPGRFLSCDEAKLIL
                     CHILLKYDFKALDGRVPDLHVRSMFIQRDTGGMLSVRRRQEEVTL"
     intron          6160..6224
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=1
     exon            6225..6341
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=2
     intron          6342..6406
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=2
     exon            6407..6506
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=3
     intron          6507..6563
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=3
     exon            6564..6632
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=4
     intron          6633..6688
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=4
     exon            6689..7282
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=5
     intron          7283..7380
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=5
     exon            7381..7802
                     /gene="Pc21g15450"
                     /locus_tag="PCH_Pc21g15450"
                     /number=6
     exon            complement(8150..8773)
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
                     /number=1
     mRNA            complement(join(<8150..8773,8837..9414,9488..>9659))
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
     gene            complement(<8150..>9659)
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
     CDS             complement(join(8150..8773,8837..9414,9488..9659))
                     /codon_start=1
                     /db_xref="GOA:B6HJU4"
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR003042"
                     /db_xref="InterPro:IPR003953"
                     /db_xref="UniProtKB/TrEMBL:B6HJU4"
                     /gene="Pc21g15460"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 192.7; E-value: 1.9e-58)"
                     /gene_kind="other"
                     /inference="protein motif:COGS:COG0644"
                     /inference="protein motif:COGS:COG0654"
                     /inference="protein motif:PFAM:PF01360"
                     /inference="similar to AA sequence:PIR:S70702"
                     /locus_tag="PCH_Pc21g15460"
                     /note="unknown EC_number=1.14.-.-; Title: strong similarity
                     to maackiain detoxification protein MAK1 - Nectria
                     haematococca"
                     /product="MAK1-type monooxygenase"
                     /protein_id="CAP96443.1"
                     /transl_table=1
                     /translation="MTVAHGVGPNGVAPPGSSGIQVIIVGLGIAGLVAAIECHYKGHVV
                     VGLERSPGIRVLGSNATKVLQSWNNGEVLRHLVSQSDDVAAMEILDPAGKLYALDSMDG
                     YGMGEGMIIHRGTLVHGLYEHAKSLGIDLRFASAATDYWEDEGQAGVTVNGEQRIAAAC
                     VVGADGVHSKTRDYVLGYQIAPQPSGLAAFRACFSANLLAGDPDAQWILEEAGVQDRMR
                     RYITTGGLGLTLSTGKRGQNVIWQVWHRKHEKADESWENVTDARVEDALALLQDWPTYP
                     QVAAVLRHTPSEKLADYKIISRDPLPTWRSRGGRIMVIGDAAHAMSAIAGQGGGQSVED
                     AATLAICLELAGKSRVNLALHVVERIRYQRTSIIQDSGNAIYSQMRDPDWETIEKDPSM
                     MKFPRPEWLFGYDVHRDVYEQFPYAMRAVQDNTGYRPRNIPSNSKYQVVHDYEKPVAA"
     mat_peptide     complement(join(8153..8773,8837..9414,9488..9554))
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
                     /product="unnamed"
     intron          complement(8774..8836)
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
                     /number=1
     exon            complement(8837..9414)
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
                     /number=2
     intron          complement(9415..9487)
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
                     /number=2
     exon            complement(9488..9659)
                     /gene="Pc21g15460"
                     /locus_tag="PCH_Pc21g15460"
                     /number=3
     sig_peptide     complement(9555..9659)
                     /gene="Pc21g15460"
                     /inference="protein motif:SignalP:2.0"
                     /locus_tag="PCH_Pc21g15460"
     exon            complement(11020..12250)
                     /gene="Pc21g15470"
                     /locus_tag="PCH_Pc21g15470"
                     /number=1
     mRNA            complement(join(<11020..12250,12361..>12665))
                     /gene="Pc21g15470"
                     /locus_tag="PCH_Pc21g15470"
     gene            complement(<11020..>12665)
                     /gene="Pc21g15470"
                     /locus_tag="PCH_Pc21g15470"
     CDS             complement(join(11020..12250,12361..12665))
                     /codon_start=1
                     /db_xref="GOA:B6HJU5"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="UniProtKB/TrEMBL:B6HJU5"
                     /gene="Pc21g15470"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 134.9; E-value: 6.5e-41)"
                     /gene_kind="biosynthetic-additional"
                     /inference="protein motif:COGS:COG2124"
                     /inference="protein motif:PFAM:PF00067"
                     /inference="similar to AA sequence:TREMBL:AF019142.1"
                     /locus_tag="PCH_Pc21g15470"
                     /note="Title: similarity to mitochondrial 25-hydroxyvitamin
                     D3 24-hydroxylase cP450cc24 - Gallus gallus"
                     /product="cytochrome P450 oxidoreductase"
                     /protein_id="CAP96444.1"
                     /sec_met_domain="p450 (E-value: 3.9e-38, bitscore: 120.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MSGYVLLTVQLAAVLLLVTLWRAFRPNTRSNRVVSYIINVGNTPK
                     IHQKNKADFHPRTNVEISPLVVPNLFDRWLNAHSDLPLSISRWRGKYQVPGGGERLPIL
                     TGADEIKAVFKDSGNHRKASNLNGGWVMGDLVGDGVGLISEGHWKRVHAVVSPPFTQKP
                     TTYVPFVQSRISRHFSELYPEDEGGRTLRIKPAEDLKLLPFWVISDLLYGNLSPEMTEE
                     LLQITDLRTDVFRYAFKGGLSLFSISKIFYPDIRNKLHVFHTRWANFNRKAYQCALNRD
                     DASACAIVTLYRAVEQGQITPTELMHTLDEALFANIDVTIGSFSWIPQFLAEDAALQSK
                     LRKEISHARSDTAPESWVKYIGSNSTLLASCINESARLKPVTNYTYAQSMPTDRDVGGY
                     RIPRGTFMVVDTNALNIWDDAWGSDKTSYRPQRFLEESRASFRYRFWRFGFGPRQCIAQ
                     ALADTILKVLVAYTVENYELKSTGKSAANEEDAHKQGEAWFKVAEQGIILEAL"
     mat_peptide     complement(join(11023..12250,12361..12596))
                     /gene="Pc21g15470"
                     /locus_tag="PCH_Pc21g15470"
                     /product="unnamed"
     intron          complement(12251..12360)
                     /gene="Pc21g15470"
                     /locus_tag="PCH_Pc21g15470"
                     /number=1
     exon            complement(12361..12665)
                     /gene="Pc21g15470"
                     /locus_tag="PCH_Pc21g15470"
                     /number=2
     sig_peptide     complement(12597..12665)
                     /gene="Pc21g15470"
                     /inference="protein motif:SignalP:2.0"
                     /locus_tag="PCH_Pc21g15470"
     exon            13202..13576
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=1
     mRNA            join(<13202..13576,13630..20184,20241..20393,20624..>20659)
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
     gene            <13202..>20659
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
     CDS             join(13202..13576,13630..20184,20241..20393,20624..20659)
                     /NRPS_PKS="Domain: AMP-binding (216-610). E-value: 5.5e-83.
                     Score: 270.6. Matches aSDomain:
                     nrpspksdomains_PCH_Pc21g15480_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (752-818). E-value: 1.6e-14. Score:
                     45.7. Matches aSDomain:
                     nrpspksdomains_PCH_Pc21g15480_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (855-1122). E-value:
                     6.8e-37. Score: 119.0. Matches aSDomain:
                     nrpspksdomains_PCH_Pc21g15480_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1288-1679). E-value:
                     2.2e-81. Score: 265.4. Matches aSDomain:
                     nrpspksdomains_PCH_Pc21g15480_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1837-1885). E-value: 2e-11. Score:
                     35.8. Matches aSDomain:
                     nrpspksdomains_PCH_Pc21g15480_PCP.2"
                     /NRPS_PKS="Domain: Condensation_DCL (1961-2227). E-value:
                     2.2e-33. Score: 107.5. Matches aSDomain:
                     nrpspksdomains_PCH_Pc21g15480_Condensation_DCL.2"
                     /codon_start=1
                     /db_xref="GOA:B6HJU6"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR001242"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR010071"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="UniProtKB/TrEMBL:B6HJU6"
                     /gene="Pc21g15480"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     264.6; E-value: 2.4e-80)"
                     /gene_kind="biosynthetic"
                     /inference="protein motif:COGS:COG1020"
                     /inference="protein motif:PFAM:PF00501"
                     /inference="protein motif:PFAM:PF00550"
                     /inference="protein motif:PFAM:PF00668"
                     /locus_tag="PCH_Pc21g15480"
                     /note="Title: strong similarity to cyclic peptide AM-toxin
                     synthase like protein An03g00650 - Aspergillus niger"
                     /product="NRPS"
                     /protein_id="CAP96445.1"
                     /sec_met_domain="Condensation (E-value: 2.2e-38, bitscore:
                     120.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-90, bitscore:
                     292.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.3e-13, bitscore:
                     38.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDSYLGRDTISFPLSKELEAEWTDNGEVLLRSHLLKACWALLLGR
                     LSETHTITFAVLEQLVAPPRDACSKLVASSPHLETWQISDRPDSLLVDAAKETHREPLS
                     GTQTSTAVVIRWHDELNGPTSLPYAFNAIVVLDCSISPAKVYMEYSRASLTVNQAWSQL
                     TATVHILEQLVMSPGISLRELDFLGSYSTKLILQWNNPYSLARPQVCIHTLILEHCRSQ
                     PDAEALCAWDGSVTYAELDRFSLAVAHQLLSLGVGPESVVPLYFEKSRWTVVAMLGVLR
                     AGGAFVLLDPSHPMPRLAEICSEVQATVVITSESLQELGRKLGPRAVTILDTINSHVDT
                     GRNAFNTSVKPSNAAYVAFTSGSTGKPKGIVIEHQCFVANTLAQNAVQNINSQTRAFQF
                     ASYGFDSSILETLMTLVAGGCVCIPSEKQRLNGLADAIRGMRANWLELTPSVARFINPE
                     EVPDVSSVLLVGEPMSQDHITQWSGSGKIQLLNAYGPAECSVVATVQPNVQLEDPQNIG
                     CSYSSHCWITNPQDHDQLEPLGAVGELLISGPIVARGYLNQPHQKSFISNPRWATRFGI
                     PPGERVYKTGDLVRYNLDDGALRYVGRKDREVKIHGQRVDLHEIEHHASRFQKGMLAVA
                     DVLQVNGGSAGKLLALFIVADNDETRMTKESFVVPMNDTLLDLVTSIKHWLRDCLPPYM
                     IPTKYTFVNRFPLTRTGKLDRRALVDLGAASSHSSTREQPSNQRDKEDVELDPGLSAKE
                     NTLCSVFAEALGCLAINIGPEDGFYDMGGNSLAAIELVARARNHGLEITVADVIRLQNP
                     RKIARCTAESKDVREISPFSLLVDTEQSLSAATAQCGIGREMIEDIYPCTPLQEGLMHL
                     SITNPGAFMGTYRFSLAPSTDLYRVWAAWEQLWLVHPILRTRIIQLQDGQKLQVVTKQK
                     LPFEDISGMDNCQPMNLGTPLARVTYHRGRGSSGSDSGIFLLTMHHALFDGWSYLQMLG
                     DLQVIYAGDKLSPRPSFKHAINYISKLSIEEGRSFWSQELKDFQATMFPTSSRRPTTSP
                     HWQVRSQQIILAESDMNWTLANKIKLAWTLVISSQTHSNDVVYGLTVSGRNAPVPEIDR
                     IVGPTFATFPFRTQLEDDISVEDMLVQMRQHDVSIMPFEHVGLRRIAESSSDAALACGF
                     QNLLTIRLQSLQMPPGALIELPENENHDLKFASYALSIVAQQEGTSLGVKAIFNSCILG
                     ADRTEALLEQFDTLLQRILREPGTKMKDLRTQLSPEWQQLAAINKKSPSHLRCLHDIIN
                     HFSITQPNSEAVCAWDGSLTYSELVALARRLAGLLQSFGSGSEPGAVIGICVERSKWFP
                     VAILGVMMSGAAMVLLEPNFPTQRLRHILRDAGARTMICSTVFQEKCAGLVDDMLVLTH
                     DIVTQADYDAWTPSAVSHHDPMYVAFTSGSTGAPKGVVIEHGMVYSMLKAHKDIIGASI
                     ASRGLLFASPAFDICLAEIVLILCSGGCVCVPSEAQRMNSLAKTMTTMQVNMAMLTPSV
                     ARTLAPAAIPCLQTLILGGEAPSASDLETWASRVKLHQSYGPAECAMYTTTTHPLTSSS
                     DLGNVGSSQNASCWIVDPDNHDELQPVGSIGELLIGGPIVGRGYINRAQESAAAFICDP
                     VWSENFPFLQGARLYKTGDLAILNADGSLNLVGRKDTQVKLNGQRIELHEIEHCAERYQ
                     HGTAVIAELIKPVGIQRPRLIMFVYDPATVETTVGIDSTCHDHRGLFLPPSRQNQAYLE
                     GVRDHLNQHLPPYMIPSHFLSLSRLPLSPSGKADRKTLRQVASKMDRETLEMYLDNPVA
                     EKRKPTTEQERFVRASFATALSLNEEAIGMDDSFFALGGDSITAMRVLTLCRRRNMAIS
                     MQEFLSKNTVTLFCKHVILIQGQAVDSKRQKLLDSQDLVRGEDHLVQFQHLDYQLDMVR
                     SQLNLLKSDSIQEIYPCSDAHSGVLELYTSNYTSTAIFEIRATGSVTPMQVSNAWSQLV
                     HRHVALRTVLMKEPKVHADYLHVVLDKGPAQILALPRSKNALSELKGLEPVKSWGLSPP
                     HRLIIGHDHSGTLFMRLETGYALIDAFSMTILLEELSLLLQGQPLPERGVSYREYLSNL
                     RSQSSAETLQYWTQVLYGVYPSHLPRVPVTQSPLPEPRSQSRCLPFAQSKRLDSFWRSN
                     NLTITNVFQLAWALTLAHYTNSRDVCFGTITSGRDIPHLEVWNIVGSFFNVLPCRIAIE
                     PTRTVIDTLRQNQEDIQRRNDHQYCSIPDMIRKSGIRSLDNNQQLFNTVLTVQNPFSIQ
                     SSTAKDGSNEIDVKLIDLEDATEYDLCVAILPSPSHLKVELRYWSTTVSEGYASDILDR
                     LFSQLEQIVHHATKPDFVQVYECTKH"
     intron          13577..13629
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=1
     exon            13630..20184
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=2
     aSDomain        13903..15084
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PCH_Pc21g15480_AMP-binding.1"
                     /evalue="5.50E-83"
                     /label="PCH_Pc21g15480_AMP-binding.1"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="610"
                     /protein_start="216"
                     /score="270.6"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="EHCRSQPDAEALCAWDGSVTYAELDRFSLAVAHQLLSLGVGPESV
                     VPLYFEKSRWTVVAMLGVLRAGGAFVLLDPSHPMPRLAEICSEVQATVVITSESLQELG
                     RKLGPRAVTILDTINSHVDTGRNAFNTSVKPSNAAYVAFTSGSTGKPKGIVIEHQCFVA
                     NTLAQNAVQNINSQTRAFQFASYGFDSSILETLMTLVAGGCVCIPSEKQRLNGLADAIR
                     GMRANWLELTPSVARFINPEEVPDVSSVLLVGEPMSQDHITQWSGSGKIQLLNAYGPAE
                     CSVVATVQPNVQLEDPQNIGCSYSSHCWITNPQDHDQLEPLGAVGELLISGPIVARGYL
                     NQPHQKSFISNPRWATRFGIPPGERVYKTGDLVRYNLDDGALRYVGRKDREVKI"
     aSModule        13903..15708
                     /complete
                     /domains="nrpspksdomains_PCH_Pc21g15480_AMP-binding.1"
                     /domains="nrpspksdomains_PCH_Pc21g15480_PCP.1"
                     /locus_tags="PCH_Pc21g15480"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       14083..14124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0001"
                     /evalue="2.40E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="290"
                     /protein_start="276"
                     /score="11.5"
                     /tool="antismash"
                     /translation="LGVLRAGGAFVLLD"
     CDS_motif       14317..14376
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0002"
                     /evalue="1.40E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="374"
                     /protein_start="354"
                     /score="29.9"
                     /tool="antismash"
                     /translation="AYVAFTSGSTGKPKGIVIEH"
     CDS_motif       14731..14757
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0003"
                     /evalue="1.80E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="501"
                     /protein_start="492"
                     /score="5.2"
                     /tool="antismash"
                     /translation="YGPAECSVV"
     CDS_motif       14863..14931
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0004"
                     /evalue="6.50E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="559"
                     /protein_start="536"
                     /score="37.7"
                     /tool="antismash"
                     /translation="PLGAVGELLISGPIVARGYLNQP"
     CDS_motif       15052..15117
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0005"
                     /evalue="3.70E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="621"
                     /protein_start="599"
                     /score="28.8"
                     /tool="antismash"
                     /translation="YVGRKDREVKIHGQRVDLHEIE"
     aSDomain        15511..15708
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PCH_Pc21g15480_PCP.1"
                     /evalue="1.60E-14"
                     /label="PCH_Pc21g15480_PCP.1"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="818"
                     /protein_start="752"
                     /score="45.7"
                     /tool="antismash"
                     /translation="ENTLCSVFAEALGCLAINIGPEDGFYDMGGNSLAAIELVARARNH
                     GLEITVADVIRLQNPRKIARC"
     aSDomain        15820..16620
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PCH_Pc21g15480_Condensation_DCL.
                     1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="6.80E-37"
                     /label="PCH_Pc21g15480_Condensation_DCL.1"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1122"
                     /protein_start="855"
                     /score="119.0"
                     /tool="antismash"
                     /translation="EDIYPCTPLQEGLMHLSITNPGAFMGTYRFSLAPSTDLYRVWAAW
                     EQLWLVHPILRTRIIQLQDGQKLQVVTKQKLPFEDISGMDNCQPMNLGTPLARVTYHRG
                     RGSSGSDSGIFLLTMHHALFDGWSYLQMLGDLQVIYAGDKLSPRPSFKHAINYISKLSI
                     EEGRSFWSQELKDFQATMFPTSSRRPTTSPHWQVRSQQIILAESDMNWTLANKIKLAWT
                     LVISSQTHSNDVVYGLTVSGRNAPVPEIDRIVGPTFATFPFRTQL"
     aSModule        15820..18909
                     /complete
                     /domains="nrpspksdomains_PCH_Pc21g15480_Condensation_DCL.1"
                     /domains="nrpspksdomains_PCH_Pc21g15480_AMP-binding.2"
                     /domains="nrpspksdomains_PCH_Pc21g15480_PCP.2"
                     /locus_tags="PCH_Pc21g15480"
                     /monomer_pairings="pro -> pro"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       16174..16239
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0006"
                     /evalue="1.10E-04"
                     /label="C3_DCL_135-156"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="995"
                     /protein_start="973"
                     /score="14.9"
                     /tool="antismash"
                     /translation="MHHALFDGWSYLQMLGDLQVIY"
     CDS_motif       16516..16611
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0007"
                     /evalue="5.00E-11"
                     /label="C5_DCL_263-294"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1119"
                     /protein_start="1087"
                     /score="35.1"
                     /tool="antismash"
                     /translation="DVVYGLTVSGRNAPVPEIDRIVGPTFATFPFR"
     aSDomain        17119..18291
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PCH_Pc21g15480_AMP-binding.2"
                     /evalue="2.20E-81"
                     /label="PCH_Pc21g15480_AMP-binding.2"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1679"
                     /protein_start="1288"
                     /score="265.4"
                     /specificity="consensus: pro"
                     /tool="antismash"
                     /translation="TQPNSEAVCAWDGSLTYSELVALARRLAGLLQSFGSGSEPGAVIG
                     ICVERSKWFPVAILGVMMSGAAMVLLEPNFPTQRLRHILRDAGARTMICSTVFQEKCAG
                     LVDDMLVLTHDIVTQADYDAWTPSAVSHHDPMYVAFTSGSTGAPKGVVIEHGMVYSMLK
                     AHKDIIGASIASRGLLFASPAFDICLAEIVLILCSGGCVCVPSEAQRMNSLAKTMTTMQ
                     VNMAMLTPSVARTLAPAAIPCLQTLILGGEAPSASDLETWASRVKLHQSYGPAECAMYT
                     TTTHPLTSSSDLGNVGSSQNASCWIVDPDNHDELQPVGSIGELLIGGPIVGRGYINRAQ
                     ESAAAFICDPVWSENFPFLQGARLYKTGDLAILNADGSLNLVGRKDTQVKL"
     CDS_motif       17293..17331
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0008"
                     /evalue="1.40E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1359"
                     /protein_start="1346"
                     /score="3.2"
                     /tool="antismash"
                     /translation="LGVMMSGAAMVLL"
     CDS_motif       17524..17583
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0009"
                     /evalue="7.20E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1443"
                     /protein_start="1423"
                     /score="27.8"
                     /tool="antismash"
                     /translation="MYVAFTSGSTGAPKGVVIEH"
     CDS_motif       17929..17955
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0010"
                     /evalue="5.60E-01"
                     /label="NRPS-A_a5"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1567"
                     /protein_start="1558"
                     /score="3.8"
                     /tool="antismash"
                     /translation="SYGPAECAM"
     CDS_motif       18067..18156
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0011"
                     /evalue="3.60E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1634"
                     /protein_start="1604"
                     /score="38.5"
                     /tool="antismash"
                     /translation="PVGSIGELLIGGPIVGRGYINRAQESAAAF"
     CDS_motif       18262..18324
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0012"
                     /evalue="1.80E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1690"
                     /protein_start="1669"
                     /score="32.8"
                     /tool="antismash"
                     /translation="VGRKDTQVKLNGQRIELHEIE"
     aSDomain        18766..18909
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PCH_Pc21g15480_PCP.2"
                     /evalue="2.00E-11"
                     /label="PCH_Pc21g15480_PCP.2"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="1885"
                     /protein_start="1837"
                     /score="35.8"
                     /tool="antismash"
                     /translation="LNEEAIGMDDSFFALGGDSITAMRVLTLCRRRNMAISMQEFLSKN
                     TVT"
     aSDomain        19138..19935
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_PCH_Pc21g15480_Condensation_DCL.
                     2"
                     /domain_subtype="Condensation_DCL"
                     /evalue="2.20E-33"
                     /label="PCH_Pc21g15480_Condensation_DCL.2"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="2227"
                     /protein_start="1961"
                     /score="107.5"
                     /tool="antismash"
                     /translation="TSNYTSTAIFEIRATGSVTPMQVSNAWSQLVHRHVALRTVLMKEP
                     KVHADYLHVVLDKGPAQILALPRSKNALSELKGLEPVKSWGLSPPHRLIIGHDHSGTLF
                     MRLETGYALIDAFSMTILLEELSLLLQGQPLPERGVSYREYLSNLRSQSSAETLQYWTQ
                     VLYGVYPSHLPRVPVTQSPLPEPRSQSRCLPFAQSKRLDSFWRSNNLTITNVFQLAWAL
                     TLAHYTNSRDVCFGTITSGRDIPHLEVWNIVGSFFNVLPCRIAI"
     CDS_motif       19474..19518
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0013"
                     /evalue="3.60E-02"
                     /label="C3_DCL_135-156"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="2088"
                     /protein_start="2073"
                     /score="6.9"
                     /tool="antismash"
                     /translation="LIDAFSMTILLEELS"
     CDS_motif       19831..19926
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_PCH_Pc21g15480_0014"
                     /evalue="9.70E-08"
                     /label="C5_DCL_263-294"
                     /locus_tag="PCH_Pc21g15480"
                     /protein_end="2224"
                     /protein_start="2192"
                     /score="24.5"
                     /tool="antismash"
                     /translation="DVCFGTITSGRDIPHLEVWNIVGSFFNVLPCR"
     intron          20185..20240
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=2
     exon            20241..20393
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=3
     intron          20394..20623
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=3
     exon            20624..20659
                     /gene="Pc21g15480"
                     /locus_tag="PCH_Pc21g15480"
                     /number=4
ORIGIN
        1 atggagaagg aggtagcaac tgatcctcta ccgcaggaga tcccaagcga cgcacccgat
       61 gaaggggggt cgctatctcg ccccgcggcg aatacttgga cggtcgtctc tctcactatt
      121 gccctttgcc taggtgtctt ttgcatgtca ctggtaagtg gaacgctgta gacagcagtc
      181 agcgttaaaa acagaagaac cgtggagagc tgacctttcc caggatgtca caattatcac
      241 aactgcgatt cctcgtatca cagatcagtt cgactcacta gacgacattg gttggtacgg
      301 cagttcgtat ctccttacaa actgcgccac taccctcgcc tttggtaaat tctacacatt
      361 ctattccaca aaatgggtat acctatctgc tctctttcta ttcgaagtcg gttcccttgt
      421 ctgcggagtt acacctacct ctgttggtct gattttgggt cggtgcattg ccggtctggg
      481 cgctggaggt ctcttctcgg ggagcctctt gatcatcgct cagactgttc ctttgcatcg
      541 tcgccctgtc ttcacggcct tacttggtag tatgtacggt attgctagtg tcgctggccc
      601 tccgtgagtt gaactacttt cttcctcttg cctttgctat ctcctaacct gatcagattg
      661 ggaggggcat tgacagatcg tgtctcctgg cgttggtgtt tctacattaa cttgcccatc
      721 ggtgctgtta ctgcggcatt cgtcctattt ttcttccacg cccccaattc agtcaaaagg
      781 cgcccagaac tacgcaaact gctgagcgag ttagatccta tcggctcgtt ctttttccta
      841 cctgccatcg tctgtcttct tctggccctc cagtggggtg gcacccaata ctcttggaaa
      901 agcccccgga tcatcgttct tttcgtgctc actggtgttc tcctgctcgc cttcgtggcc
      961 gttcagatcc gccagaatga aaaagccaca cttcctccgc gtatcgtcca aaatcgaaac
     1021 atctggtcat cagcctggtt tgccattaca cttaatggtg catactttgt cttcatttac
     1081 tacgtatgtc gagtctacaa cagctccgtg atcgctcaag ctaactttct agcttcccat
     1141 atggttccag gcaataaagg cggcctcggc cacgaaatca ggtgttatga atctaccgag
     1201 catcatcgca gttgttgtcg tctctattat atccggtatg ctcgtcacta tcttcggcta
     1261 ctacaacccc gtcatgatta tgtcctcggt cacattatcc atcggggctg gtctactcag
     1321 taccctcaag acagactcag ggagtggcga atggatcgga taccagattc taatgggatt
     1381 gggggtcggt ctcggaatgc aacagccgtt catggtggtg cagaatgtgc tacccgacgg
     1441 cgacgttccc actggtacgg ccgtgataac atttgcgcag accttgggag gtgcaatctt
     1501 tatttctgtg ggtcaaaata tcttccagaa ccagtttgct catactatgc acttggaaga
     1561 tccctcggtg aatgtagcca cagttctctc ggctggcacg accacattgc ggaagtatct
     1621 tccagctgaa cagctgccag ccgtcctaag atcctacaat accgctatta cccaggcctt
     1681 ttatgttggc gtggctttgg cgtcactttc ctgtattgga actatcgcgt tggaatggaa
     1741 gtctgtcaag aagccgagaa acactacacc caacgatcac agtgggagtt gaatgtggat
     1801 gtgacttggg caggtaacta tatagcagag ctaaatgacg gcttaagccg tccttaatgt
     1861 taatttcggg gatcacatat agagactcaa aattgaacgc ataaggcgct aaggaagccc
     1921 ttaagtcacc cgagggcccc agtgtctttc ttgcccttaa catacaaagt actccgtatt
     1981 cagtaattga ttgctataac ttgaacttca attttcaagt ggtccatcca catcccagcc
     2041 tcggcctctc atatcttgac gagtcaagtc atcggggttc ctgtcgcagg ggccgtcgca
     2101 gggcgcgctg tattgactgg cagaaagtta ttggtcgctt gttcttttct tttctttttt
     2161 gctttttttc ctccattttt ctctcacaaa atcaaatcca ctagtgcctt gttgggcgcc
     2221 tggattttcc ttgacatatc ttgcttggcc tttgattcaa cttcctcaaa aaggaacagg
     2281 gcaacctgca ttggaatttg cccaggcgag cggagtcatg tggcaacaga tggaaccctg
     2341 cggagtacac gtagaattcc cttacatgat gtgacatgtc taatcggcac atgccaacat
     2401 cgtagcctgg ttgtactccg tacgtagcac gaagtcatgg aaagtattca gccgcataac
     2461 ataccaagtg ccactgcatg agacgagtct tcgggtccta ctccaaaatg gaaacttgag
     2521 ctattggcac tggcgtggaa tatagggccc acatcttgca ttttcaatgg cctttggaca
     2581 acattaaaga tctccgactt actttcttcc tagacaaata ctcataccgc tatcccagaa
     2641 tgacagtctc ttccactgtt cagcctctca aggcctgtgt gccagaggcc acagaagcgg
     2701 cagatatgcc tcaccataca ctcagcaagt cgatgacctt tgccaatctg gaccaatacc
     2761 aatactggca tgccgtgggt ccgatgctgg ggagaatgct ctccaatggc agctacagca
     2821 tccacaagca atatgaatac ctgtgtctct ttgcgcatgt tataattcca aagctgggac
     2881 cgttcccggg tgggagggat atctacaaat gtctgctcgg aggaactggc tccgtggagc
     2941 tgagtcagaa tgttcagaaa ttaggcctga ctgcacgggt tgccttcgag cctacaagct
     3001 acattgctag caccggtgtc gacccactca accggcacac tgtccacgct accctggtcg
     3061 agttgagggc tatagggtct gccagcatcg acatggagct gcatcaaatg cttgtcaacg
     3121 agctgacatt gacggaccgc gaagaaagac tgatgtcccc ggaagcaatc tcgggaaccg
     3181 cgtggaagac gcaaattctg cttgctttgg atttgggtca aaccggaatc acaatcaagg
     3241 agtatttcta tccggccctc aaagcttccg tgacggggca aagcgtggcc aagttgtgct
     3301 tctctgctat tcggaaagtg gacaagcaag gacgttttga gcctgcaagc aaggcgattg
     3361 agacctatat gaaaacacag agccagacag acctttactt tttgtcctgt gatctggtcg
     3421 atccagcggc aactcggatc aagctttacc tgatggagct tgacatgagg ttggcaaagg
     3481 tcgaggagca ctggaccatg ggcggcaagc tcaatgacga agagacattg cttggactga
     3541 aaatgctgca agaactgtgg gtagagtttg ggattatcga aggcatgcga aatgagccgg
     3601 agcggccatc gctgcctggg gatccggaca ctattgttcc atttattatg aactatgaga
     3661 tgagtcccgg cgaggcattg cccaaaccca aattctactt ccccttggtc ggcattcccg
     3721 agctgaaaat tgcaaatgtg ctcactgcct ttttcgaacg ctacggtatg cctgagcagg
     3781 ccgcagtcta tcgcaataat ttgcagacat actagtaggt tccctctcta ggcgcacacg
     3841 cggaatgttt cttgctaatc tgactcgtgt aatatcagcc ctagcaagga cttggttatc
     3901 gcaacggatc accaggcatg gctgtccttt tcatacacca agaaaaaagg accatacctc
     3961 accatgtact atcactagga tattacaata gtcacagtca gggtacgctt gaagcagagg
     4021 agctacggtt tcaagagtga ttgcggagcg gcatgaaagg atgggcaatt tgttcatata
     4081 taatttagct agccagaatg aagaagagcc aatgccccat gggaatatcc tgttcttcaa
     4141 gtagtgcttc tcaaatccgc aaacattacg caaatatcag aagataattc tctctttgtg
     4201 tgctaaagaa gattaagata tggggcgagg gtttctccag tctctgcacc cactttcggg
     4261 ataatattca gtaaataaaa cgacacttca aagctatgga tactaggctg actgctaccg
     4321 tctcgctggt tgccctaaga tcccttctga ccagttgcaa aaacagcagt ccactcctgt
     4381 ggcaccagac cgttctctcc ataagtttca ttcagatgcc tctgaagtgc tggcaggata
     4441 tcattctcat acttatccct ttgctcctgg ttccaccatt tactaacaat gataggaatg
     4501 accggctgtg cgatcttgta caagtcctcg acgctagttt cgaattgctt cgaaattgta
     4561 gtgacttgga cgctgtggaa ccctgcctcc tcaaatctag agtgaacgta gtcttccgaa
     4621 tcccatcctg ggttcataca ggacatgaat tccttggtag ttgggaatgg tagatctgcc
     4681 ggtattatgg caacagcggc ctcaacaacg gcaagccact cagctgtgat acgtcagaac
     4741 ttgagatcat gtagcgggcg agacatactt cgctgccaag ttgagatagt aagcgttccc
     4801 cccggctgaa gaatccgcat gacctctgtt tatgaacatg agcttctatt tgagcacgcc
     4861 ttgattatga gtgagccaac ctttcattgc agcataggta tcgggaaatg aggtaaaggc
     4921 taaatggcga cagtatctta tatcagtgat tggttgaatt caagtggttc cgacattttg
     4981 cgtaccaaga gccgcaaaca cgtgagtata atgtccggta gggagctcgg tgttttgcgc
     5041 atccaccacc ttggcaattg aattctccca tcctctctcc aaaatcttct gcttcacatg
     5101 gccagtaagc tcagttgata tatcgccgca cgtcagttcc cagttccctt ttggctggaa
     5161 attcaacatg tcatggaggg catcagagac aacacccgtt ccgcaggcga ggtccagaat
     5221 taccagaggt gtcagactag attcactcag tcccgagagc tgaatcagat cctgggtata
     5281 atagcgggtg atcttttccg cgaccatgta ggtatcaagg attcccttgc ccgcgtagag
     5341 ctcggtaaag ttggtggcgc gagtcatgat aggatggtga tgctgatgga tcaaacaatt
     5401 ggggcaatat ttgttggcta ggatttagag aaagcgatag agagatatta tctttggcgg
     5461 tttataagat cgggatgcat tttcctaata ggatagtagc agtggacgtg atatatttac
     5521 attcttcagc tctgtacgga gtccagacta cctccggagt acttcatgca atccatcaga
     5581 gacaaaggaa aggttcgatg aaagacatag gcatggtttc cactactcga tctagacttc
     5641 tgcatagccg tacgtgcctt tgcattgcat gcaaggagtc actagacggt gggtcccgca
     5701 ttccaactgg tctgaatgtt gtatggacta cttcgtgctg cgtaaagatc ccaagggtta
     5761 cagccactaa aagaactgca ggttgtcctt acagacgcac aatctgacct tgtagaccat
     5821 ttgaaatacc gtcagcctcg caaaacagga tttccccatg tcacttcgga agatctaccg
     5881 ttgcactaga tataccttgt atgcgcaata agttggtcaa tcgagccgac aaagaaagaa
     5941 cagtcgacaa tggatgtggt tgccagattc atggtttcct actcagggac agcatgtgca
     6001 atttcactgt ttatctttgg aattaccttg ctgtttccat ttcacaaaag ccaatccttc
     6061 gtctgcatga actcgcactc gtgggatatt ttcagaaaca aagcaaagcg agaattcgaa
     6121 tcaaatgcag aaaagctcat caaagatgca ctacgaaagg tcggttaatt taacccgtca
     6181 tgtgttggta gcaggacgac gacgacgatt gctgacaccc acaggggctc acggccttcc
     6241 aattggtaac caacatgggc acctatctga tccttgcaga ccaatacgcc gaagaactga
     6301 gaaacgataa aaggcttagc gcttatgatg ccttgaatga tgtatgtgtt ttttcccttt
     6361 ctcgaaatgt tcattatgca tagttgtctg atccagtcac ttgcaggtaa tcttgctgga
     6421 gctgccgggc cttgaaacta tgtttcaggg ctcgctgcat aaccatgtgt cccctactgc
     6481 aatccatgct atgaacaggg agctaggtaa gtggctgggc cctggactgt tcgatccatg
     6541 catgattaat tgccacctcg cagtccactt gactcgggcg ctgtcggatg aagcaaacca
     6601 ccgtctgcag actcagtgga cggacagttc cggtatgctc gaattgccca ctcacactga
     6661 tcttaccgtg gagtctgata aattgcagaa tggcacactg tttcaatcca cgacactgtc
     6721 ttggccttgg ttgctcagat gaccacgcga gcatttgtcg gagcggagct gtgccgcaat
     6781 gccgaatggc tcgatattgc cattaacttt acgataaacc gggctattgc agtccaggca
     6841 gtccaggctt ggccatggat cctgcagccc gttgtccatt ggttcttgcc cacctgcaag
     6901 gctgtccgcc gccagattca gcgagctcga accatcctga tgccagttct agaacgtgag
     6961 aggcagacta tgcacagaaa agactcgtca tctgaccgaa tattctcgac attaactttc
     7021 attgatcagt atgctcaagg gtctcgctac gacgccacca tggcccagct gagactgacc
     7081 gctgtatctg tcttgaccac atccgacatg gtggagaagg tactggcaag aatttgcgag
     7141 catccagaac taatccagcc gctccgtgag gaagtagtgt cggtctttga aagtagtggc
     7201 ttgcatcaca agtccttact caagctgaca ctcatggaga gcgtgatgaa agaaagccag
     7261 cggcttgaac ctgccacact gagtgcgttg tttcttttct tttcttttcg tttttttctt
     7321 tcctccccca ttcccagttt ggctttgtct ttcttccttg ctgattactt tgattttcag
     7381 tctccatgtt ccgcgccgct aagaagacag tcacattgca agatggtaca actatcccta
     7441 agggtacccg tcttgccttt gcaaacgacc ttcgtctaga ccctgagttg tatccggatc
     7501 ccgaaacctt tgacggttat cgatttgaaa gaatgaggaa agatccagag caggctaagc
     7561 ttgccccatt taccaaaacg aggacgagtc atttggcctt cggccatggg aaacatgctt
     7621 gtcctgggag gttcctttcg tgcgatgaag ctaagttgat tctttgtcat atcttgctca
     7681 agtacgactt caaagcatta gatgggcgtg tccctgatct gcatgttcgc agcatgttta
     7741 tccagagaga tacaggaggg atgctctcgg tgaggagacg ccaggaggaa gttacactgt
     7801 aaagatagct atgcctacac tgaattatta aatcaatctg ttattgttcc atcgaaaggg
     7861 gttgtggtca gtgtatattc ctaaaggcct atagttctgg ccaaataaat tgctaggatt
     7921 tgaacagtat caggaaggtt caaccgacct acgtcgtagt tgggagactt tgctattgta
     7981 cgatggctaa tttatcggct cctagtccct tcgacactat atttagaatg ataatacaaa
     8041 tcttcggcgc gaagtatata tttcagcata atcaaatgta aaactcggat attcaagaaa
     8101 taggggcaag gctagcaaga ctatataaca tgccaacgag aagatgtcat caagctgcca
     8161 ctggcttctc gtaatcgtgc accacctggt acttgctgtt ggatggaata ttccgtggcc
     8221 gatagcccgt gttatcttga acagctctca tcgcatatgg aaactgctcg taaacatcac
     8281 ggtgaacgtc gtagccgaag agccactcag gacgtgggaa cttcatcatc gacggatctt
     8341 tctcaatcgt ctcccagtcc ggatctcgca tctgactata aatcgcatta ccactgtcct
     8401 ggataatgct ggtccgctgg tatcgaattc tttccaccac atggagagcc agattcaccc
     8461 ggcttttacc tgccagctcc agacaaatgg ctaacgtagc cgcatcttca acagactgac
     8521 cacctccctg gcccgcaatc gccgacatcg cgtgggctgc atcgcctatg accatgatgc
     8581 gcccaccacg ggaacgccat gtcggcagag gatcacgaga gatgatcttg tagtctgcga
     8641 gcttttcgct gggcgtgtgt cgcagaacag cagccacttg agggtacgta ggccagtcct
     8701 ggagtaaggc gagggcatcc tcaacacggg catcggtgac attttcccag gactcatcag
     8761 ccttctcgtg tttctgaaaa cccccaatac caagtcagtt ttcgtctcga tgctcgaagt
     8821 tgtgagtaat acacacccgg tgccagacct gccaaatcac attctggccg cgttttccag
     8881 ttgacaaagt caaccccaga cccccggtcg ttatgtacct tcgcatccga tcctgcacac
     8941 ctgcttcctc cagaatccat tgagcatcag gatcacccgc cagcaagttg gcgctgaagc
     9001 atgcacgaaa cgcagctagt ccagagggct gaggagcaat ttgatatcct agcacataat
     9061 ctcgggtctt gctatgtacg ccgtccgcgc ccacgacaca ggcagccgca atccgttgct
     9121 caccattgac agtcacaccg gcttgaccct catcctccca gtaatcggtg gcagctgagg
     9181 caaagcgcaa atcaataccc agggatttgg catgttcgta taacccatgg accaatgttc
     9241 cacgatggat aatcatgccc tctcccatgc catacccgtc catggaatcc aaggcataca
     9301 gcttccccgc ggggtctaga atctccatgg cggcgacatc gtcggactga gagacaagat
     9361 gacgcagcac ttcaccattg ttccaactct gtaggacctt tgtcgcgttg ctccctaagg
     9421 caatgctatc tcctgctcca gtcaataaat gacccatgga caaccgattt ggtgtcatat
     9481 agctcaccta gaactctgat gcccggactt ctctcaaggc cgactaccac atgtcccttg
     9541 tagtggcact cgatggcagc aaccagacca gcaatcccaa gcccgacaat aatcacttgg
     9601 attccacttg aaccaggtgg cgcgactcca ttgggaccaa cgccgtgtgc tacagtcatc
     9661 gtgatgcgct tgattaaaca gttaactttg tggcttcgga ctagtatcta caataagcac
     9721 gacacaatcc ctctttatgg ccactcggcc gccgatcgtc actacagcgg cttggaccat
     9781 accacatgct agtcggcgat tgtgggctag atggcgggct taccctgcat ccttctgact
     9841 gcagtcatcg tgaacataac ttgctttatg catcgagtat tgcgttccga tgacaccatg
     9901 cgatgtctcg atgcgctgtt tgctccaggt agtattgaat ctaccatgta gaccgccacc
     9961 acaccgctgc ggaatgacgc cttggaacca atccctacta aatgtcacct gtaatgtaca
    10021 ggtgactccc aaggcaggtc gcctcgaaaa tgctgcaatg cacgactaca ggaatagccc
    10081 caacccggga ttgagctaag cctatttcgg aaatagccca aagccaagaa tggctcagga
    10141 ctacctactt gcctttcatg cctggggtta tgcaggatag ttggctgcaa tgcactccgt
    10201 atgaatgcga ggtgaggtaa gaatgcgaga aaatggtata ccagttccga cgcggtgaga
    10261 catgtggaga gcccgctacg ggtacggaga tcgcggatcg ggcctgatgc aagggagatt
    10321 agccacggcg cctccacatt cactaacaca atgactgcag agaatcagat gctacgtcgt
    10381 attctgtgtc tcccttggca ctgcagttta gcggagaaaa catccgtgat atggatctgc
    10441 gaaaatctct cctagggctc cgtgtccgtt gattggctca caagaacatt aggccaacat
    10501 cggtctccac tactagttgg aaatcatgca gcattagcgt agggtagtct aaggcaatag
    10561 tgcatggact atcgattgcc tatcgattcc ctctcaattc cgagtgcgat ctggatcgtg
    10621 actgatatta tctgcagggg gtaaccggat tttttggtct tacaatggct gatgcgtgag
    10681 cgagaccgag gcacgagact tagacttgct tcgaaatgac gcgaagggta gctgtgggct
    10741 gtgtcgaaat ttgatggctc gagaacgacg tggtcatagc cagtggatag tagcatagat
    10801 cttgacatag acaagcctta caagacaccg gtagttctta ctccctgccc aaccggtatt
    10861 atacaatgtg gttgttcgga gtacatcatc atccaaacat agtcataaat ctcacagtta
    10921 gaatgcagaa tccgagcaaa aagagttcaa accaaccaag gcatgtattt caactagcca
    10981 gatattccca gcctactcaa atagagaaaa gaacatgtac tatagcgctt ccaaaatgat
    11041 tccctgctct gcaaccttga accacgcttc gccttgttta tgggcatcct cctcattcgc
    11101 agcagacttc ccagtggatt tcaactcgta gttctcaaca gtgtacgcaa ccagaacctt
    11161 gaggatcgtg tctgccaacg cctgcgcaat acactggcgg ggcccaaagc caaaccgcca
    11221 aaagcgatac cgaaagctgg ccctggactc ctccaggaac cgctgagggc ggtagcttgt
    11281 tttatcagag ccccaggcgt catcccagat attcaaggca ttggtgtcaa ccaccataaa
    11341 ggtaccacgg ggaatgcggt atccacccac gtcacggtca gtgggcatcg actgcgcgta
    11401 ggtgtagttg gtgactggct tcaacctcgc agattcattt atgcagctcg ccagcagagt
    11461 cgagttgctg ccaatgtatt tgacccatga ttcaggagcc gtgtcagatc tggcgtgtga
    11521 gatctctttc ctaagcttgc tctgtaaagc ggcatcctca gccagaaatt gtgggatcca
    11581 ggagaagctg ccaattgtaa cgtcgatgtt ggcaaacagt gcttcgtcca atgtgtgcat
    11641 cagctcggtt ggtgtaatct gaccttgttc gacggctcta tacaaggtaa caatagcaca
    11701 agcagaggca tcgtcacggt ttaatgcaca ttgatatgct ttcctattga aattggccca
    11761 gcgagtgtgg aagacgtgta gcttgttcct tatgtcaggg taaaatatct tgctgatgga
    11821 gaacagcgat aatccaccct tgaaggcata tcgaaacaca tccgtgcgca ggtctgtgat
    11881 ttgcaagagt tcctctgtca tctccgggga caggttccca tataagaggt cgctaatgac
    11941 ccagaagggc aggagcttga gatcctcagc gggcttgatg cgcagcgttc tcccgccttc
    12001 atcctccggg tatagctcgg agaaatggcg agaaatgcgg gactggacaa agggaacata
    12061 ggtcgtaggt ttctgggtga atggtggtga aactacagca tggactcgtt tccagtgccc
    12121 ttcactgatg agtccgacac cgtcacccac tagatcgccc attacccatc caccattcag
    12181 gtttgaagcc ttgcggtggt taccagagtc tttaaagact gccttgatct catccgcgcc
    12241 ggtcaaaatg ctatgctttt gtttagcata ggcggttcat cttaggagag gaagctcaca
    12301 tttctggcgt gagaccaacc cagattcgat ataccgggcc atatttctcg gcccactgac
    12361 gggagacgtt ctccgcctcc aggaacttga tacttccccc gccatctgga aatcgatagg
    12421 ggcaagtcgg aatgggcgtt gagccatctg tcgaataaat tgggtaccac cagaggagaa
    12481 atctctacgt tggtacgagg atgaaagtca gccttgttct tttgatgtat ttttggagta
    12541 ttaccaacat ttattatgta ggaaactact cgatttgacc gagtatttgg tcgaaaggcg
    12601 cgccacaatg tgactagaag taatacagct gccaactgca ccgtaagaag aacgtaacct
    12661 gacattatgt ggagctgacg ttgggaagaa gcagaagcaa caaatggcgg atttaaatga
    12721 cgagtttgaa ttcaatttgc aatcaacagc atgtccgcat tttcctgaat aggcacgtcc
    12781 agtgatagag ccgatcttat tcgaattccc acaagtgcgg ctgacaatcc agggcaactt
    12841 caccgagtgg ccagaatctg acatgtacaa agtacgtgtg ggtcaaatgt tgatcagcaa
    12901 ggatcaacat gcatggtcgc atcacattga tctagacgac cgcatggcgt tgagatatgc
    12961 aaggacttgt ggggattgtt gtaggtgtag ccatggacta agaaccattg gtggccagcc
    13021 tgagcttggc ggctatacaa cattcttgtt gctgaccacc cattcttggc cactttcgaa
    13081 gatatatccg ggagaagtca tttcggcgga agtacgagca ttccatgtat tcattaccgc
    13141 gaaggaaccc ccatatctcg ggaggaacct taactttcgg agtacttgtc ccatcatcgc
    13201 catggattct tatcttggtc gtgatactat ctcctttcct ttgagtaagg aattggaagc
    13261 agaatggact gataatggcg aagtattgct ccgatcacat cttctcaagg catgctgggc
    13321 cttgttgctt ggcaggctct cagaaacaca cacgataact tttgcagtgt tggagcaact
    13381 cgtagcccct ccaagggatg cgtgttcgaa attagtggct tcatctcccc atttagagac
    13441 atggcaaata tcagacaggc cggatagtct cttggtggat gcagcgaagg aaacgcacag
    13501 agaacctctt tcgggcacac agacctcgac ggctgtggtc atcaggtggc atgatgaact
    13561 gaacggcccg acgtctgtaa gtagcagtcg gtaatgcgat tttctctcga cgtactaata
    13621 gagtctcagt taccctatgc attcaatgca attgttgttt tggactgcag tatatcaccc
    13681 gccaaagtat atatggaata ctcaagagcc tctctcacag tgaaccaagc ctggtcacaa
    13741 ttaacggcta cggttcacat tctcgagcaa ctagttatga gcccagggat atcacttcgg
    13801 gagctggatt tcctgggctc atatagtaca aaattgatcc tgcaatggaa caatccgtac
    13861 tcactcgcac gcccacaagt gtgcattcac accttgatcc tggagcattg ccggagccag
    13921 ccagatgccg aagcgctgtg tgcttgggat ggttctgtca catatgcaga acttgatcga
    13981 ttttcactcg cagtcgcaca ccagctgctg tcacttggtg ttggcccaga gtcagtggtg
    14041 ccgctgtact tcgaaaagtc gcgctggacg gtagtcgcca tgctgggagt gctcagagcg
    14101 ggaggtgctt ttgtcctcct tgatccttct catcctatgc ctcgactggc cgagatttgc
    14161 tcggaggtgc aggcaacagt tgtcatcacc tcggagtcat tacaggaact cggacggaag
    14221 ctgggccctc gagctgtcac gatcctcgac acaataaata gtcatgtcga tacaggcaga
    14281 aacgccttta acacatctgt gaagccttca aatgccgcat acgtggcttt tacttccggg
    14341 tccactggga agcccaaagg aatcgtgatt gaacatcagt gcttcgttgc aaacacgcta
    14401 gcccagaacg cagtccagaa tattaatagt caaacacggg catttcagtt tgcttcttat
    14461 gggtttgaca gcagcattct cgagacactc atgactttgg tggcgggtgg ttgcgtgtgt
    14521 ataccctcgg agaagcagcg gctgaacggc ctggcagatg ctatccgcgg gatgcgagcc
    14581 aactggcttg aactgacccc atctgtcgcg cggttcatca accctgaaga ggtaccggac
    14641 gtgagctctg tcttgcttgt cggtgaaccc atgtctcaag accacatcac acaatggtcg
    14701 gggtcgggaa agatccagct cctcaatgcg tacggccccg ccgagtgcag tgtggtggcc
    14761 actgtgcagc ccaatgtgca actggaagat ccccaaaata tcggctgctc atacagcagt
    14821 cactgctgga tcacgaatcc tcaagatcat gaccagctcg agcccctggg tgcggtggga
    14881 gagttactca tcagcggacc aatcgtggcc cgaggctacc tcaaccagcc ccaccagaag
    14941 tctttcatct ccaaccctcg ttgggcgacg cgattcggga ttcctccagg tgagcgcgtt
    15001 tacaaaacgg gagatctcgt gcgatataac cttgacgatg gcgcgttgcg atatgttggg
    15061 cgcaaagacc gggaggtgaa aatccacggg caacgtgtcg acttgcacga aattgaacat
    15121 catgcctccc ggtttcagaa gggaatgctt gcagtggccg atgtacttca agtgaacggt
    15181 ggcagtgcgg ggaaactcct tgctttgttt attgtcgcag ataatgatga gactcgcatg
    15241 acgaaggaaa gcttcgttgt ccccatgaat gacaccctcc tcgatttggt gaccagtatc
    15301 aagcattggc ttcgcgactg tctaccgcca tatatgattc caacgaaata tacgttcgtc
    15361 aatcgctttc ctctgacgag aactggcaaa ctcgatcgac gagccttggt tgatcttgga
    15421 gcagcatcca gccactcatc gacaagagag caaccgtcaa atcagcgtga taaagaagat
    15481 gtcgagttgg acccggggct ttctgccaag gaaaacactc tatgctccgt ctttgctgag
    15541 gctttagggt gtctcgcaat taacattggc ccagaagacg gtttctacga catgggagga
    15601 aattcactag ctgctatcga gctggtagcc cgtgcacgca atcatggtct cgagatcacg
    15661 gtggcggatg tcatccgtct ccagaatcca cgaaagattg cgcgatgcac tgcggaaagc
    15721 aaagacgtcc gcgagatctc accattctct ctcctcgtgg ataccgaaca gagtctatcc
    15781 gccgcgaccg cgcagtgtgg cattgggaga gaaatgattg aagatattta cccttgcact
    15841 cctctccagg aaggtctcat gcacctgtca attaccaatc caggagcatt catgggcaca
    15901 tatcgattct ccttggctcc ttctacggac ctttatcggg tctgggctgc atgggaacag
    15961 ctttggctcg tacaccccat tctccgaacg cgaatcatcc agcttcaaga tggccaaaag
    16021 cttcaagtag tcacgaagca aaagctccca ttcgaggata tttcaggcat ggataattgt
    16081 cagcccatga acttgggcac cccgcttgca cgtgtgacat atcatcgtgg acggggttcc
    16141 agcggatcgg actctggtat attcctgctg accatgcatc acgccctttt tgatggatgg
    16201 tcatatctgc agatgctcgg ggatctccag gtgatttacg ctggggacaa attgtcacca
    16261 cgcccttcct tcaaacatgc cattaactac atctccaagc tcagcattga ggaaggtcgc
    16321 tctttctgga gccaagagct caaagatttc caagcaacaa tgttccctac ctcctcccgg
    16381 cggccaacca cttcaccaca ttggcaagtc agaagccagc aaattatcct ggccgaatca
    16441 gatatgaatt ggaccctcgc caataagatc aaattagcgt ggactcttgt gatctcttcc
    16501 caaactcact caaacgatgt ggtatacgga ttgactgtct cgggccgaaa cgccccagtt
    16561 ccagagatcg atcgtattgt tgggccaact ttcgcaacat ttccattccg tacgcagctt
    16621 gaggacgaca tatcggtgga agatatgttg gttcaaatgc gacagcacga cgtctctatc
    16681 atgccatttg agcatgttgg actcaggcgt atcgcagagt caagctcaga cgcggccctg
    16741 gcttgtggat tccagaatct cctcaccatt aggttgcaat ctcttcagat gcctcccggc
    16801 gccctgattg agttacctga gaacgaaaat catgacctga agtttgcgtc gtatgccctg
    16861 tcaatcgtcg cccagcagga aggcacatcg ctgggggtca aggccatctt taatagctgc
    16921 attctgggcg ctgataggac cgaggcactc ttggaacagt tcgatacatt attgcagcga
    16981 atcctccgag aacctgggac aaaaatgaag gatctgagga cgcagctttc tcctgagtgg
    17041 cagcaattgg cagcgataaa caaaaagagt ccgtcccacc ttcgttgcct acatgatatt
    17101 atcaaccact tcagcatcac ccaaccaaac tctgaggccg tctgcgcatg ggatggctcg
    17161 ctcacatata gcgaacttgt cgcgttagcg cggagattgg caggtcttct gcagtctttc
    17221 ggatccgggt cggagcccgg tgcggtcatc gggatttgcg tcgaaagatc gaaatggttc
    17281 cctgttgcca ttctgggtgt catgatgtct ggagccgcca tggttctgtt ggaacccaac
    17341 ttccccacac agcgtttgcg gcatatcttg cgagacgctg gggcgcgaac gatgatatgc
    17401 tctacggtat tccaagagaa atgcgcgggc ttggttgatg acatgttggt tctgactcac
    17461 gatattgtga cccaagcgga ctacgatgct tggaccccat cagccgtctc tcaccacgac
    17521 ccaatgtatg tcgcgtttac atccgggtca acgggtgcgc caaagggagt tgtgatcgag
    17581 catggcatgg tatactcgat gctcaaggca cacaaggaca tcattggcgc atcaattgct
    17641 tcccggggtt tgcttttcgc gtcgcctgcg tttgatatct gccttgctga gattgtactt
    17701 atcctctgtt ccgggggctg cgtctgtgtg ccttctgaag ctcaacgcat gaacagcttg
    17761 gcgaaaacca tgacaaccat gcaggtcaac atggccatgc tgaccccttc ggtggcgcga
    17821 accctcgcgc cagcagcgat tccttgtctc caaaccctga ttcttggagg tgaggcacca
    17881 tcagcatctg atctggagac atgggcttca cgggtcaagc tgcatcagtc ctatgggccg
    17941 gccgaatgtg ctatgtacac gactactaca cacccgttga cttccagctc ggatttggga
    18001 aacgtcgggt cttcccaaaa cgcgtcttgt tggatcgttg acccggacaa ccatgatgag
    18061 cttcagcctg taggctcgat aggagagcta ttgatcggtg ggccgattgt tggaagaggg
    18121 tatatcaacc gagcccagga gtctgccgct gccttcattt gcgatcccgt ctggagtgaa
    18181 aactttccct tcttgcaagg agcgcgactt tacaagactg gagatctggc tatcttgaac
    18241 gcagacgggt ctttaaattt ggtcggccga aaggacacac aggtcaaact caacgggcag
    18301 cggattgaat tgcacgagat tgagcattgt gccgagagat accaacacgg taccgcggtt
    18361 attgcagaat tgataaagcc tgtcggcata caaagacccc gacttatcat gttcgtctat
    18421 gatcctgcga ctgtagaaac gacggtgggc atcgattcta cttgtcacga ccatcgggga
    18481 ctgtttctcc caccgtcaag gcaaaatcaa gcttaccttg aaggtgtaag agaccatctc
    18541 aaccaacacc ttccacccta tatgatacct tcccattttc tttcgctatc tcgtctgccg
    18601 cttagcccaa gtggcaaggc tgaccgcaag acattacgcc aggttgcatc gaaaatggat
    18661 agagagacac tggagatgta tctggacaat ccagtggcag agaaaaggaa accaaccaca
    18721 gagcaagagc gattcgtccg tgcaagcttt gccacagccc tgtccttaaa tgaggaggcc
    18781 attggtatgg acgatagctt cttcgccttg ggaggcgatt ccatcactgc catgcgggtt
    18841 ctcactttgt gtcggagaag gaatatggcc atctcgatgc aggaattctt atcaaagaac
    18901 accgtaacac tgttttgcaa acatgtcatt ctgattcagg gccaggccgt tgattccaag
    18961 cgccagaaac tcctggattc ccaagacttg gtgcgagggg aagatcatct cgtccagttt
    19021 cagcacctcg actaccagct ggatatggtt cgatctcagt tgaatttgct gaaatcggat
    19081 tctattcagg aaatctaccc ttgctctgac gcccacagtg gagtgttgga gctctatacg
    19141 tccaattaca cgagcactgc aattttcgaa attcgtgcta cgggatcagt taccccgatg
    19201 caggtgagca acgcttggag tcaactagtg caccgtcatg tggccttacg gacggttctc
    19261 atgaaagagc caaaggttca tgcagattat cttcatgtag tcctcgacaa gggaccagct
    19321 caaattcttg ctcttcctcg cagcaagaat gccctttcgg aactgaaagg ccttgaacca
    19381 gtcaaatcct ggggcctgtc gccaccacac cggttaatca tcggtcatga ccattccggg
    19441 acactcttca tgagactgga aacgggctat gccttgattg acgccttttc catgaccatt
    19501 ctactagaag agctttctct cctgctccag ggtcagcctt tgccagagcg aggggtctcg
    19561 tatcgtgaat atctgtccaa tttgcgcagc cagtcatctg cagaaacatt gcaatactgg
    19621 acacaggtgc tttacggagt ttacccttcc cacctgccca gagtccctgt cacgcagtca
    19681 cctctgcctg aacctcgttc acagagccgc tgcctgccat ttgcacaatc gaagcgccta
    19741 gattccttct ggcgctccaa taatcttacc atcaccaacg ttttccagct agcatgggcc
    19801 ttaaccctcg ctcactatac caattcccgc gatgtgtgct tcggaaccat cacctcggga
    19861 cgtgatatcc cccacctaga agtatggaat attgtcggat cattcttcaa cgttcttccg
    19921 tgccgaattg cgattgaacc cacgcgcacg gtgatagaca ctctgcgaca gaaccaggag
    19981 gatattcagc gtcgaaatga ccaccaatac tgttccatac cggatatgat ccgcaaatct
    20041 ggaataagaa gcttggacaa caaccaacag ctatttaata cagttttgac agttcagaac
    20101 ccattctcga tacaatcgtc cactgcgaaa gatgggagca acgagatcga tgtcaaactc
    20161 atcgatttag aggatgcaac tgaggtgagc gccttcggaa cgtgaaccat gataagaccg
    20221 actaatcata attctttcag tatgaccttt gcgttgctat tcttccctcc ccttcccacc
    20281 tcaaggtgga actacgttac tggtcgacca ccgtgtctga gggatatgct tcggatattc
    20341 tggatcgcct tttcagccag ctggaacaaa tcgtgcatca tgcgaccaag ccagtgagtg
    20401 tcatcgccag cattggatga taaacaaacc atatatctct ttcgactacg accctttcat
    20461 gattgctcct ttgatgagga tacgaagttc gaggtcaatt ataacgtgca cttttgttgt
    20521 ctaataatct tctactgttt acttgatatt tccacgttat gtgctctcag atactcccgg
    20581 gtccaattga caataataca aatcattaaa tactgattta aaggactttg tccaagtcta
    20641 cgagtgcacc aagcattag
//
