BGC0000420: histidyltryptophanyldiketopiperazine biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
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Location: 3,638,081 - 3,658,739 nt. (total: 20,659 nt).
This entry is originally from NCBI GenBank AM920436.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000420
Short description histidyltryptophanyldiketopiperazine biosynthetic gene cluster from Penicillium rubens Wisconsin 54-1255
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AM920436.1
Compounds
  • histidyltryptophanyldiketopiperazine
  • dehydrohistidyltryptophanyldiketopiperazine
  • roquefortine D
  • roquefortine C
  • glandicoline A
  • glandicoline B
  • meleagrine
Species Penicillium rubens Wisconsin 54-1255 [taxonomy]
References
Chemical products information
histidyltryptophanyldiketopiperazine [synonyms: htd]
(no structure information available)
dehydrohistidyltryptophanyldiketopiperazine [synonyms: dhtd]
(no structure information available)
C17H15N5O2
roquefortine D
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C22H25N5O2
Chemical database entries
NPAtlas
roquefortine C [synonyms: Isoroquefortine C, Roquefortine]
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C22H23N5O2
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NPAtlas
PubCHEM
glandicoline A
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C22H21N5O3
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PubCHEM
glandicoline B
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C22H21N5O4
Chemical database entries
PubCHEM
meleagrine
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C23H23N5O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PCH_Pc21g15420
  • CAP96439.1
  • Pc21g15420
 3638081 - 3639872 (+) Transporter
  • Transport
Sequence-based prediction
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  • PCH_Pc21g15430
  • CAP96440.1
  • Pc21g15430
 3640720 - 3642058 (+) dimethylallyltryptophan synthase
  • Tailoring (Prenylation)
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  • PCH_Pc21g15440
  • CAP96441.1
  • Pc21g15440
 3642415 - 3643447 (-) methyltransferase
  • Tailoring (Methylation)
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  • PCH_Pc21g15450
  • CAP96442.1
  • Pc21g15450
 3644030 - 3645882 (+) P450 monooxygenase
  • Tailoring (Oxidation)
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  • PCH_Pc21g15460
  • CAP96443.1
  • Pc21g15460
 3646230 - 3647739 (-) MAK1-type monooxygenase
  • Tailoring (Oxidation)
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  • PCH_Pc21g15470
  • CAP96444.1
  • Pc21g15470
 3649100 - 3650745 (-) cytochrome P450 oxidoreductase
  • Tailoring (Oxidation)
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  • PCH_Pc21g15480
  • CAP96445.1
  • Pc21g15480
 3651282 - 3658739 (+) NRPS
  • Scaffold biosynthesis
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
Pc21g15480
Module 0
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Homology
Module 1
Specificity: histidine
Evidence for specificity:
  • Structure-based inference
  • Homology
Condensation domain type: DCL
Module 2
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 53KWSSAVU3NHQPX32A2FHV6D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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