Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000420.1:
Cluster 1NRP120659

BGC0000420, roquefortine C / meleagrin biosynthetic gene cluster from Penicillium rubens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: histidyltryptophanyldiketopiperazine
Molecular formula: C17H17N5O2
Exact molecular mass: 324.1455 Da ([M+H]+)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Other (linear)
Thioesterase type:
Release / cyclization type:

Nonribosomal peptide synthetases:
roqA (CAP96445.1)
Module 0
A specificity: Tryptophan
Evidence for specificity: Activity assay
C domain subtype: N/A
Module 1
A specificity: Histidine
Evidence for specificity: Activity assay
C domain subtype: DCL
Module 2
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: DCL

Gene cluster description

roquefortine C / meleagrin (BGC0000420). Gene Cluster 1. Biosynthetic class = NRP. GenBank AM920436. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
Contact for this cluster:Arnold J.M. Driessen (University of Groningen)

Literature references

1. Ali H et al. (2013 TI) A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum. PLoS One 8(6):e65328. doi: 10.1371/journal.pone.0065328. Print 2013.
2. Ries MI et al. (2013) Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway. J Biol Chem 288(52):37289-95. doi: 10.1074/jbc.M113.512665. Epub
3. Garcia-Estrada C et al. (2011) A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem Biol 18(11):1499-512. doi: 10.1016/j.chembiol.2011.08.012.