BGC0000421: safracin A biosynthetic gene cluster from Pseudomonas fluorescens
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 17,974 nt. (total: 17,974 nt).
This entry is originally from NCBI GenBank AY061859.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000421
Short description safracin A biosynthetic gene cluster from Pseudomonas fluorescens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY061859.1
via
Compounds
  • safracin A
  • safracin B
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
safracin A Evidence:
Copy SMILES
C28H36N4O6
Chemical database entries
PubCHEM
safracin B Evidence:
Copy SMILES
C28H36N4O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAL33754.1
  • sfcJ
 150 - 1679 (-) putative monooxygenase/hydroxylase
    copy AA seq
    copy Nt seq
    • AAL33755.1
    • sfcI
    		 1669 - 2331 (-) putative methyltransferase
      copy AA seq
      copy Nt seq
      • AAL33756.1
      • sfcA
      		 2870 - 5884 (+) putative non-ribosomal peptide synthetase
        copy AA seq
        copy Nt seq
        • AAL33757.1
        • sfcB
        		 5898 - 9089 (+) putative non-ribosomal peptide synthetase
          copy AA seq
          copy Nt seq
          • AAL33758.1
          • sfcC
          		 9093 - 13391 (+) putative non-ribosomal peptide synthetase
            copy AA seq
            copy Nt seq
            • AAL33759.1
            • sfcD
            		 13420 - 14472 (+) hypothetical protein
              copy AA seq
              copy Nt seq
              • AAL33760.1
              • sfcE
              		 14537 - 14722 (+) hypothetical protein
                copy AA seq
                copy Nt seq
                • AAL33761.1
                • sfcF
                		 14780 - 15847 (+) methyltransferase
                  copy AA seq
                  copy Nt seq
                  • AAL33762.1
                  • sfcG
                  		 15933 - 16976 (+) putative methyltransferase
                    copy AA seq
                    copy Nt seq
                    • AAL33763.1
                    • sfcH
                    		 17062 - 17604 (+) conserved hypothetical protein
                      copy AA seq
                      copy Nt seq
                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      sfcA
                      Substrates
                      glycine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      sfcB
                      Substrates
                      glycine, 3-hydroxy-4-methoxyphenylalanine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      sfcC
                      Substrates
                      3-hydroxy-O-methyltyrosine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2024-05-15
                      MIBiG v4 annotathon
                      • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
                      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                      A domain glossary is available here, and an explanation of the visualisation is available here.
                      Selected features only
                      Show module domains
                      Similar known gene clusters from MIBiG 4.0
                      Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                      Click on reference genes to show details of similarities to genes within the current region.
                      Click on an accession to open that entry in the MiBIG database.