BGC0000421: safracin A biosynthetic gene cluster from Pseudomonas fluorescens
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Location: 1 - 17,974 nt. (total: 17,974 nt).
This entry is originally from NCBI GenBank AY061859.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000421
Short description safracin A biosynthetic gene cluster from Pseudomonas fluorescens
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AY061859.1
via
Compounds
  • safracin A
  • safracin B
Species Pseudomonas fluorescens [taxonomy]
References
Chemical products information
safracin A Evidence:
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C28H36N4O6
Chemical database entries
PubCHEM
safracin B Evidence:
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C28H36N4O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAL33754.1
  • sfcJ
150 - 1679 (-) putative monooxygenase/hydroxylase
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    • AAL33755.1
    • sfcI
    1669 - 2331 (-) putative methyltransferase
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      • AAL33756.1
      • sfcA
      2870 - 5884 (+) putative non-ribosomal peptide synthetase
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        • AAL33757.1
        • sfcB
        5898 - 9089 (+) putative non-ribosomal peptide synthetase
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          • AAL33758.1
          • sfcC
          9093 - 13391 (+) putative non-ribosomal peptide synthetase
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            • AAL33759.1
            • sfcD
            13420 - 14472 (+) hypothetical protein
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              • AAL33760.1
              • sfcE
              14537 - 14722 (+) hypothetical protein
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                • AAL33761.1
                • sfcF
                14780 - 15847 (+) methyltransferase
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                  • AAL33762.1
                  • sfcG
                  15933 - 16976 (+) putative methyltransferase
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                    • AAL33763.1
                    • sfcH
                    17062 - 17604 (+) conserved hypothetical protein
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      sfcA
                      Substrates
                      glycine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      sfcB
                      Substrates
                      glycine, 3-hydroxy-4-methoxyphenylalanine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      sfcC
                      Substrates
                      3-hydroxy-O-methyltyrosine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      MIBiG v4 annotathon
                      • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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