BGC0000422 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000422 (Streptomyces lavendulae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	melanin,NRPS	1	62,804	saframycin A/saframycin B	NRPS:Type I	100%

BGC0000422 - Region 1 - NRPS,melanin

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Location: 1 - 62,804 nt. (total: 62,804 nt) Show pHMM detection rules used

Region on contig edge.

melanin: melC
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 62,805
Label		BGC0000422

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000422	1.07	NRP	saframycin A, saframycin B	Streptomyces lavendulae
BGC0000910	0.51	Other	melanin	Streptomyces coelicolor A3(2)
BGC0000911	0.49	Other	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000912	0.41	Other	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001050	0.39	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001133	0.37	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002017	0.35	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001168	0.34	NRP	livipeptin	Streptomyces lividans 1326
BGC0000457	0.33	NRP	vicibactin	Rhizobium etli CFN 42
BGC0002347	0.33	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000422	1.00	NRP	saframycin A, saframycin B	Streptomyces lavendulae
BGC0000910	0.79	Other	melanin	Streptomyces coelicolor A3(2)
BGC0000911	0.78	Other	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000912	0.73	Other	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000662	0.70	Terpene	grixazone A	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001133	0.70	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002017	0.68	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0001168	0.67	NRP	livipeptin	Streptomyces lividans 1326
BGC0000457	0.66	NRP	vicibactin	Rhizobium etli CFN 42

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 57763:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala) + (Gly) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 4413 - 57763:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ala) + (Gly) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sfmA

Search NORINE for peptide: strict or relaxed

CAL_domain (124..567): pk

minowa: NH2

Prediction, score:

NH2: 95.7
Acetyl-CoA: 18.2
fatty_acid: 12.0
shikimic_acid: 0.0
AHBA: 0.0

AMP-binding (1236..1624): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNNALTYK
Nearest Stachelhaus code(s):: Ala DLFNNALTYK (100% 8Å match); Gly DLFNNALTYK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

sfmB

Search NORINE for peptide: strict or relaxed

AMP-binding (456..845): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

sfmC

AMP-binding (475..876): X

nrpys: ohdmTyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DPWGLGLIDK
Nearest Stachelhaus code(s):: ohdmTyr DPWGLGLIDK (100% 8Å match); ohmeTyr DPWGLGLIDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)