BGC0000423: scabichelin biosynthetic gene cluster from Streptomyces scabiei 87.22
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Location: 9,541,287 - 9,571,306 nt. (total: 30,020 nt).
This entry is originally from NCBI GenBank FN554889.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000423
Short description scabichelin biosynthetic gene cluster from Streptomyces scabiei 87.22
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FN554889.1
9541287 - 9571306
via
Compounds
  • scabichelin
Species Streptomyces scabiei 87.22 [taxonomy]
References
Chemical products information
scabichelin Evidence:
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C26H49N9O10
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCAB_85431
  • CBG75488.1
 9541287 - 9543020 (+) putative ABC transport system integral membrane component
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    • SCAB_85441
    • CBG75489.1
    		 9543017 - 9544885 (+) putative ABC-transport system ATP-binding component
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      • SCAB_85451
      • CBG75490.1
      		 9544882 - 9545955 (+) putative secreted siderophore-binding lipoprotein (transport system associated)
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        • SCAB_85461
        • CBG75491.1
        		 9546026 - 9546235 (-) putative MbtH homolog
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          • SCAB_85471
          • CBG75492.1
          		 9546250 - 9565308 (-) putative NRPS/siderophore biosynthesis protein
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            • SCAB_85481
            • CBG75493.1
            		 9565505 - 9566545 (+) putative siderophore transport system integral membrane component, FecCD family
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              • SCAB_85491
              • CBG75494.1
              		 9566828 - 9567937 (+) putative siderophore transport system integral membrane component, FecCD family
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                • SCAB_85501
                • CBG75495.1
                		 9567942 - 9568856 (+) putative siderophore transport system ATP-binding component
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                  • SCAB_85511
                  • CBG75496.1
                  		 9568900 - 9569847 (-) putative formyltransferase
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                    • SCAB_85521
                    • CBG75497.1
                    		 9569900 - 9571306 (+) putative peptide N-oxygenase
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      SCAB_85471
                      Substrates
                      ornithine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      SCAB_85471
                      Substrates
                      serine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      SCAB_85471
                      Substrates
                      ornithine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      SCAB_85471
                      Substrates
                      ornithine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      SCAB_85471
                      Substrates
                      ornithine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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