BGC0000424: serobactin C biosynthetic gene cluster from Herbaspirillum seropedicae SmR1
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Location: 2,645,251 - 2,687,402 nt. (total: 42,152 nt).
This entry is originally from NCBI GenBank CP002039.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000424
Short description serobactin C biosynthetic gene cluster from Herbaspirillum seropedicae SmR1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP002039.1
2645251 - 2687402
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • serobactin C
  • serobactin B
  • serobactin A
Species Herbaspirillum seropedicae SmR1 [taxonomy]
References
Chemical products information
serobactin C Evidence:
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C37H63N7O17
serobactin B Evidence:
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C35H59N7O17
serobactin A Evidence:
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C33H55N7O17
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Hsero_2337
  • ADJ63836.1
  • cirA
 2645251 - 2647749 (+) TonB-dependent transducer
  • Regulation
  • Knock-out
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  • Hsero_2338
  • ADJ63837.1
  • pfrI
 2647830 - 2648366 (+) ferric regulator sigma-24 subunit protein
  • Regulation
  • Knock-out
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  • Hsero_2339
  • ADJ63838.1
 2648532 - 2648753 (+) MbtH-like protein
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    • Hsero_2340
    • ADJ63839.1
    		 2648760 - 2649509 (+) thioesterase involved in non-ribosomal peptide biosynthesis protein
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      • Hsero_2341
      • ADJ63840.1
      		 2649511 - 2650191 (+) 4'-phosphopantetheinyl transferase protein
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        • Hsero_2342
        • ADJ63841.1
        		 2650197 - 2651225 (+) clavaminic acid synthetase (CAS)-like protein
        • Tailoring
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        • Hsero_2343
        • ADJ63842.1
        		 2651343 - 2678825 (+) Serobactin synthetase
        • Scaffold biosynthesis
        • Knock-out
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        • Hsero_2344
        • ADJ63843.1
        		 2679043 - 2679996 (-) esterase/lipase protein
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          • Hsero_2345
          • ADJ63844.1
          • fhuA
          		 2680085 - 2682202 (-) TonB-dependent Fe3+-serobactin transporter
          • Transport
          • Knock-out
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          • Hsero_2346
          • ADJ63845.1
          		 2682281 - 2683612 (-) L-ornithine N5-monooxygenase protein
          • Tailoring
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          • Hsero_2347
          • ADJ63846.1
          		 2683634 - 2684638 (-) acetyltransferases, including N-acetylases of ribosomal proteins
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            • Hsero_2348
            • ADJ63847.1
            		 2684744 - 2685556 (-) iron reductase protein
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              • Hsero_2349
              • ADJ63848.1
              • pvdE
              		 2685720 - 2687402 (+) ABC-type siderophore (cyclic peptide) export system protein
              • Transport
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              Biosynthesis information

              Biosynthetic modules

              Name
              1
              Type
              nrps-type1
              Genes
              Hsero_2343
              Substrates
              3-hydroxyaspartic acid (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation, epimerase
              Name
              2
              Type
              nrps-type1
              Genes
              Hsero_2343
              Substrates
              serine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (DCL), adenylation
              Name
              3
              Type
              nrps-type1
              Genes
              Hsero_2343
              Substrates
              3-hydroxyaspartic acid (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation, hydroxylase
              Name
              4
              Type
              nrps-type1
              Genes
              Hsero_2343
              Substrates
              threonine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (LCL), adenylation, epimerase
              Name
              5
              Type
              nrps-type1
              Genes
              Hsero_2343
              Substrates
              serine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (DCL), adenylation
              Name
              6
              Type
              nrps-type1
              Genes
              Hsero_2343
              Substrates
              N5-hydroxyornithine (evidence: Structure-based inference, Sequence-based prediction)
              Integrated Monomers
              Domains
              condensation (DCL), adenylation
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Corrected NRP module activity
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Corrected NRP gene names
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: 2EUPHFNFSB4J4GBDL2SYVJGJ)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
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