BGC0000425: sessilin A biosynthetic gene cluster from Pseudomonas sp. CMR12a
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Location: 1 - 69,799 nt. (total: 69,799 nt).
This entry is originally from NCBI GenBank JQ309920.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000425
Short description sessilin A biosynthetic gene cluster from Pseudomonas sp. CMR12a
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: JQ309920.1
Compounds
  • sessilin A
Species Pseudomonas sp. CMR12a [taxonomy]
References
Chemical products information
sessilin A [synonyms: s-a]
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C96H168N22O26
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFH75317.1
  • nodT
 20 - 1459 (-) outer membrane efflux protein
  • Transport
Sequence-based prediction
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  • AFH75318.1
 1522 - 2337 (-) LuxR family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AFH75319.1
  • syrD
 2647 - 4344 (+) cyclic peptide transporter
  • Regulation
Sequence-based prediction
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  • AFH75320.1
  • sesA
 4806 - 24047 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • AFH75321.1
  • sesB
 24044 - 43444 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • AFH75322.1
  • sesC
 43822 - 64995 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • AFH75323.1
  • macA
 65117 - 66268 (+) macrolide-specific efflux protein
  • Transport
Sequence-based prediction
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  • AFH75324.1
  • macB
 66271 - 68229 (+) macrolide export ATP-binding/permease protein MacB
  • Transport
Sequence-based prediction
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  • AFH75325.1
 68337 - 69722 (-) diaminobutyrate-2-oxoglutarate aminotransferase
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Thioesterase genes
  • sesC (Unknown)
NRP-synthases
Gene Modules
sesA
Module 1
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 2
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 3
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 4
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 5
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 6
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
sesB
Module 10
Specificity: glutamine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 11
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 12
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 7
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 8
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 9
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
sesC
Module 13
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 14
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 15
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 16
Specificity: homoserine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 17
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 18
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 4VPAMSFU7CTQRXZA3KNXYTFK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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