BGC0000425: sessilin A biosynthetic gene cluster from Pseudomonas sp. CMR12a
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Location: 1 - 69,799 nt. (total: 69,799 nt).
This entry is originally from NCBI GenBank JQ309920.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
Operons
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000425
Short description sessilin A biosynthetic gene cluster from Pseudomonas sp. CMR12a
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
JQ309920.1
via Knock-out studies
Compounds
  • sessilin A
Species Pseudomonas sp. CMR12a [taxonomy]
References
Chemical products information
sessilin A Evidence:
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C96H168N22O26
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFH75317.1
  • nodT
 20 - 1459 (-) outer membrane efflux protein
  • Transport
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  • AFH75318.1
 1522 - 2337 (-) LuxR family transcriptional regulator
  • Regulation
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  • AFH75319.1
  • syrD
 2647 - 4344 (+) cyclic peptide transporter
  • Regulation
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  • AFH75320.1
  • sesA
 4806 - 24047 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
  • Knock-out
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  • AFH75321.1
  • sesB
 24044 - 43444 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
  • Knock-out
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  • AFH75322.1
  • sesC
 43822 - 64995 (+) nonribosomal peptide synthetase
  • Scaffold biosynthesis
  • Knock-out
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  • AFH75323.1
  • macA
 65117 - 66268 (+) macrolide-specific efflux protein
  • Transport
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  • AFH75324.1
  • macB
 66271 - 68229 (+) macrolide export ATP-binding/permease protein MacB
  • Transport
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  • AFH75325.1
 68337 - 69722 (-) diaminobutyrate-2-oxoglutarate aminotransferase
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    Biosynthesis information

    Biosynthetic modules

    Name
    1
    Type
    nrps-type1
    Genes
    sesA
    Substrates
    threonine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Starter), adenylation
    Name
    2
    Type
    nrps-type1
    Genes
    sesA
    Substrates
    proline (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    3
    Type
    nrps-type1
    Genes
    sesA
    Substrates
    serine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    4
    Type
    nrps-type1
    Genes
    sesA
    Substrates
    leucine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    5
    Type
    nrps-type1
    Genes
    sesA
    Substrates
    valine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    6
    Type
    nrps-type1
    Genes
    sesA
    Substrates
    glutamine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    10
    Type
    nrps-type1
    Genes
    sesB
    Substrates
    glutamine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    11
    Type
    nrps-type1
    Genes
    sesB
    Substrates
    leucine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    12
    Type
    nrps-type1
    Genes
    sesB
    Substrates
    valine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    7
    Type
    nrps-type1
    Genes
    sesB
    Substrates
    leucine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    8
    Type
    nrps-type1
    Genes
    sesB
    Substrates
    valine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    9
    Type
    nrps-type1
    Genes
    sesB
    Substrates
    valine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    13
    Type
    nrps-type1
    Genes
    sesC
    Substrates
    threonine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    14
    Type
    nrps-type1
    Genes
    sesC
    Substrates
    threonine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    15
    Type
    nrps-type1
    Genes
    sesC
    Substrates
    isoleucine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    16
    Type
    nrps-type1
    Genes
    sesC
    Substrates
    homoserine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Name
    17
    Type
    nrps-type1
    Genes
    sesC
    Substrates
    2,4-diaminobutyric acid (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Name
    18
    Type
    nrps-type1
    Genes
    sesC
    Substrates
    lysine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Operons
    Genes Evidence
    sesC, sesA, sesB
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Corrected NRP module activity
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated NRP substrate specificities
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: 4VPAMSFU7CTQRXZA3KNXYTFK)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Detailed domain annotation
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