Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000425.1:
Cluster 1NRP169799

BGC0000425, sessilin biosynthetic gene cluster from Pseudomonas sp. CMR12a. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: sessilin A
SMILES string: Copy to clipboard
Molecular formula: C96H168O25N22
Exact molecular mass: 2030.4 Da ([M+2H]2+)
Molecular activity: Antifungal, Surfactant

Class-specific details

Biosynthetic class(es):
NRP
Cyclic depsipeptide (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Unknown

Nonribosomal peptide synthetases:
(AFH75320.1)
Module 1
A specificity: 2,3-Dehydro-2-aminobutyric acid
Evidence for specificity: Structure-based inference
C domain subtype: Starter
Module 2
A specificity: D-proline
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 3
A specificity: D-serine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 4
A specificity: D-leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 5
A specificity: D-valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 6
A specificity: D-glutamine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
(AFH75321.1)
Module 10
A specificity: D-glutamine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 11
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 12
A specificity: D-valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 7
A specificity: D-leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 8
A specificity: D-valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 9
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
(AFH75322.1)
Module 13
A specificity: 2,3-Dehydro-2-aminobutyric acid
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 14
A specificity: D-allothreonine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 15
A specificity: Isoleucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 16
A specificity: Homoserine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 17
A specificity: 2,4-Diaminobutyric acid
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 18
A specificity: Lysine
Evidence for specificity: Structure-based inference
C domain subtype: Dual

Gene cluster description

sessilin (BGC0000425). Gene Cluster 1. Biosynthetic class = NRP. GenBank JQ309920. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Monica Hofte (Ghent University)

Literature references

1. D'aes J et al. (2014) To settle or to move? The interplay between two classes of cyclic lipopeptides in the biocontrol strain Pseudomonas CMR12a. Environ Microbiol 16(7):2282-300. doi: 10.1111/1462-2920.12462. Epub