BGC0000426 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000426 (Paenibacillus larvae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	11,658	sevadicin	NRPS:Type I	100%

BGC0000426 - Region 1 - NRPS

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Location: 1 - 11,658 nt. (total: 11,658 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 11,659
Label		BGC0000426

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000426	1.00	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.37	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000351	0.35	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000396	0.34	NRP	nodularin	Nostoc sp. 73.1
BGC0002071	0.33	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001834	0.31	NRP	argyrin	Cystobacter sp. SBCb004
BGC0001878	0.31	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001843	0.31	NRP	tridecaptin M	Paenibacillus sp. M-152
BGC0001846	0.28	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0000320	0.28	NRP	cereulide	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000426	1.00	NRP	sevadicin	Paenibacillus larvae
BGC0001133	0.70	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0000351	0.68	NRP	exochelin	Mycolicibacterium smegmatis MC2 155
BGC0000396	0.67	NRP	nodularin	Nostoc sp. 73.1
BGC0002071	0.66	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001834	0.65	NRP	argyrin	Cystobacter sp. SBCb004
BGC0001878	0.65	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001843	0.64	NRP	tridecaptin M	Paenibacillus sp. M-152
BGC0001846	0.62	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0000320	0.62	NRP	cereulide	Bacillus cereus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 11658:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Phe) + (D-Ala - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sevA

Search NORINE for peptide: strict or relaxed

AMP-binding (27..417): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTIAAICK
Nearest Stachelhaus code(s):: Phe DAWTIAAICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

sevB

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AMP-binding (470..870): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVTNFALIYK
Nearest Stachelhaus code(s):: Ala DVTNFALIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1987..2381): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DALAVGQVVK
Nearest Stachelhaus code(s):: Trp DALAVGQVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)