BGC0000426: sevadicin biosynthetic gene cluster from Paenibacillus larvae
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Location: 1 - 11,658 nt. (total: 11,658 nt).
This entry is originally from NCBI GenBank KF318360.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000426
Short description sevadicin biosynthetic gene cluster from Paenibacillus larvae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KF318360.1
via Knock-out studies
Compounds
  • sevadicin
Species Paenibacillus larvae [taxonomy]
References
Chemical products information
sevadicin Evidence:
Copy SMILES
C23H26N4O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGZ03650.1
  • sevA
 1 - 3243 (+) sevA
  • Scaffold biosynthesis
  • Knock-out
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  • AGZ03651.1
  • sevB
 3268 - 11658 (+) sevB
  • Scaffold biosynthesis
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Biosynthesis information

Biosynthetic modules

Name
1
Type
nrps-type1
Genes
sevA
Substrates
phenylalanine (evidence: Structure-based inference [1])
Integrated Monomers
Domains
adenylation, epimerase
Name
2
Type
nrps-type1
Genes
sevB
Substrates
alanine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (DCL), adenylation, epimerase
Name
3
Type
nrps-type1
Genes
sevB
Substrates
tryptophan (evidence: Structure-based inference [1])
Integrated Monomers
Domains
condensation (DCL), adenylation
Annotation changelog

Entry version: 4

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
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Entry version: 3

Date
Changes
Submitters
Reviewers
2022-09-15
Corrected NRP module activity
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  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Updated NRP substrate specificities
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Entry version: 2

Date
Changes
Submitters
Reviewers
2019-10-16
Migrated from v1.4
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2015-06-12
Submitted
  • (ID: M2JBIQNJAZIP5YVYS7CZLALR)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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Similar known gene clusters from MIBiG 4.0
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