Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000426.1:
Cluster 1NRP111658

BGC0000426, sevadicin biosynthetic gene cluster from Paenibacillus larvae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Sevadicin
SMILES string: Copy to clipboard
Molecular formula: C23H26N4O4
Exact molecular mass: 423.2026 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP
Other (linear)
Thioesterase type:
Type I
Release / cyclization type:
Hydrolysis

Nonribosomal peptide synthetases:
sevA (AGZ03650.1)
Module 1
A specificity: Phenylalanine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: N/A
sevB (AGZ03651.1)
Module 2
A specificity: Alanine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: DCL
Module 3
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
C domain subtype: DCL

Gene cluster description

sevadicin (BGC0000426). Gene Cluster 1. Biosynthetic class = NRP. GenBank KF318360. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Daniel Petras (TU Berlin / AK Suessmuth)

Literature references

1. Garcia-Gonzalez E et al. (2014) Elucidation of sevadicin, a novel non-ribosomal peptide secondary metabolite produced by the honey bee pathogenic bacterium Paenibacillus larvae. Environ Microbiol 16(5):1297-309.