BGC0000430 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000430 (Nodularia spumigena CCY9414)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	22,001	spumigin E/Spumigin E	NRPS:Type I+PKS:Type I	100%

BGC0000430 - Region 1 - NRPS

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Location: 1 - 22,001 nt. (total: 22,001 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 22,002
Label		BGC0000430

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000430	1.00	NRP, Polyketide	spumigin E	Nodularia spumigena CCY9414
BGC0001748	0.35	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0002324	0.30	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0002437	0.28	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002492	0.27	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0001637	0.27	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001627	0.26	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000313	0.26	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.26	NRP	enniatin	Fusarium equiseti
BGC0002135	0.26	NRP	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000430	1.00	NRP, Polyketide	spumigin E	Nodularia spumigena CCY9414
BGC0001748	0.68	NRP, Polyketide	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0002324	0.64	NRP, Polyketide	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0002437	0.62	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002492	0.61	NRP	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0001637	0.60	NRP	kleboxymycin	Klebsiella oxytoca
BGC0001627	0.60	NRP	isonitrile lipopeptides	Mycobacterium tuberculosis H37Rv
BGC0000313	0.60	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.59	NRP	enniatin	Fusarium equiseti
BGC0002135	0.59	NRP	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 22001:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - Pro - Arg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

NSP_49230

Search NORINE for peptide: strict or relaxed

AMP-binding (534..927): X

nrpys: Hty

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DLAFTGCVTK
Nearest Stachelhaus code(s):: Hty DLAFTGCVTK (100% 8Å match); Leu DLAFTGCVTK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2055..2486): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHAVK
Nearest Stachelhaus code(s):: Pro DVQFIAHAVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3153..3575): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVETTGAVTK
Nearest Stachelhaus code(s):: Arg DVETTGAVTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

NSP_49250

CAL_domain (229..644): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 67.7
NH2: 10.5
AHBA: 9.5
shikimic_acid: 0.0
Acetyl-CoA: -2.9