Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000430.1:
Cluster 1NRP / Polyketide122001

BGC0000430, spumigin biosynthetic gene cluster from Nodularia spumigena. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: spumigin E
PubChem ID: 71449303
SMILES string: Copy to clipboard
Molecular formula: C31H42N6O7
Average molecular mass: 610.712 Da
Molecular activity: Inhibitor
Molecular target: Trypsin

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Other (linear)
Thioesterase type:
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
Module 1
A specificity: Homotyrosine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 2
A specificity: Proline
Evidence for specificity: Activity assay
C domain subtype: DCL
Module 3
A specificity: Argininal
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Other
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Thioesterase type:
Release / cyclization type:

Modular polyketide synthases:
Module 0
AT specificity: 4-hydroxyphenylpyruvate
Evidence for specificity: Activity assay
KR stereochemistry: Unknown

Gene cluster description

spumigin (BGC0000430). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank CP007203, positions 4978680-4956680. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
Contact for this cluster:David Fewer (University of Helsinki)

Literature references

1. Fewer DP et al. (2009) The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularia spumigena. Mol Microbiol 73(5):924-37. doi: 10.1111/j.1365-2958.2009.06816.x. Epub