BGC0000430: spumigin E biosynthetic gene cluster from Nodularia spumigena CCY9414
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Location: 4,953,880 - 4,975,880 nt. (total: 22,001 nt).
This entry is originally from NCBI GenBank CP007203.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
Operons
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000430
Short description spumigin E biosynthetic gene cluster from Nodularia spumigena CCY9414
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
CP007203.2
4953880 - 4975880
via
Compounds
  • spumigin E
  • Spumigin E
Species Nodularia spumigena CCY9414 [taxonomy]
References
Chemical products information
spumigin E Evidence: MS/MS [1], Chemical derivatisation [1]
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C31H42N6O7
Chemical database entries
PubCHEM
Spumigin E Evidence: Mass spectrometry [1]
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C31H42N6O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • NSP_49190
  • AHJ31211.1
 4953880 - 4955931 (-) ABC transporter ATP-binding protein
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    • NSP_49200
    • AHJ31212.1
    		 4956128 - 4956943 (-) Pyrroline-5-carboxylate reductase
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      • NSP_49210
      • AHJ31213.1
      		 4957066 - 4958169 (-) Sorbitol dehydrogenase
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        • NSP_49220
        • AHJ31214.1
        		 4958300 - 4959094 (-) hypothetical protein
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          • NSP_49230
          • AHJ31215.1
          		 4959157 - 4971672 (-) Long-chain-fatty-acid--CoA ligase
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            • NSP_49240
            • AHJ31216.1
            		 4971674 - 4972474 (-) lichenysin synthetase A
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              • NSP_49250
              • AHJ31217.1
              		 4972452 - 4975880 (-) Long-chain-fatty-acid--CoA ligase
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                Biosynthesis information

                Biosynthetic modules

                Name
                1
                Type
                nrps-type1
                Genes
                NSP_49230
                Substrates
                homotyrosine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                2
                Type
                nrps-type1
                Genes
                NSP_49230
                Substrates
                proline (evidence: Activity assay)
                Integrated Monomers
                Domains
                condensation (DCL), adenylation
                Name
                3
                Type
                nrps-type1
                Genes
                NSP_49230
                Substrates
                arginine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                0
                Type
                pks-trans-at-starter
                Genes
                NSP_49250
                Substrates
                Integrated Monomers
                Domains
                ligase, ketoreductase, carrier (ACP)
                Operons
                Genes Evidence
                NSP_49250, NSP_49190, NSP_49220, NSP_49230, NSP_49200, NSP_49210
                Annotation changelog

                Entry version: next

                Date
                Changes
                Submitters
                Reviewers
                2024-04-23
                MIBiG v4 annotathon
                • (ID: D4PT7DYQL5DZKSW73RASEGB6)
                • (ID: BAJIZJS2YANDM4M7JHS5DFUK)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated NRP substrate specificities
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: BAJIZJS2YANDM4M7JHS5DFUK)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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