Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000431.1:
Cluster 1NRP154895

BGC0000431, stenothricin biosynthetic gene cluster from Streptomyces roseosporus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Stenothricin
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
NRP
Cyclic depsipeptide (cyclic)
Thioesterase type:
Type II
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
No gene ID (EFE73308.1)
Module 0
A specificity: Cysteic acid
Evidence for specificity: Structure-based inference
C domain subtype: N/A
No gene ID (EFE73312.1)
Module 1
A specificity: Threonine
Evidence for specificity: Structure-based inference
C domain subtype: Starter
Module 2
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 3
A specificity: 2,3-Diaminopropionic acid
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 4
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
Module 5
A specificity: Threonine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 6
A specificity: Valine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
No gene ID (EFE73313.1)
Module 7
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 8
A specificity: Lysine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 9
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation

Gene cluster description

stenothricin (BGC0000431). Gene Cluster 1. Biosynthetic class = NRP. GenBank DS999644, positions 870145-925039. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Neha Garg (University of California at San Diego)

Literature references

1. Liu WT et al. (2014) MS/MS-based networking and peptidogenomics guided genome mining revealed the stenothricin gene cluster in Streptomyces roseosporus. J Antibiot (Tokyo) 67(1):99-104. doi: 10.1038/ja.2013.99. Epub 2013 Oct