BGC0000432 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000432 (Streptomyces rochei)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	34,051	streptothricin F/streptothricin E/streptothricin D/streptothricin C	NRPS:Type I	100%

BGC0000432 - Region 1 - NRPS-like

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Location: 1 - 34,051 nt. (total: 34,051 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,052
Label		BGC0000432

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000432	1.00	NRP	streptothricin	Streptomyces rochei
BGC0001925	0.33	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001206	0.32	Other	indolmycin	Streptomyces griseus subsp. griseus
BGC0000820	0.32	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0002020	0.32	Saccharide, NRP	photolose	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000900	0.31	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.31	NRP	dimethylcoprogen	Alternaria alternata
BGC0001561	0.30	NRP	curacomycin	Streptomyces curacoi
BGC0000348	0.29	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000876	0.28	Other	neopolyoxin C	Streptomyces tendae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000432	1.00	NRP	streptothricin	Streptomyces rochei
BGC0001925	0.66	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001206	0.65	Other	indolmycin	Streptomyces griseus subsp. griseus
BGC0000820	0.65	Alkaloid	physostigmine	Streptomyces griseofuscus
BGC0002020	0.65	Saccharide, NRP	photolose	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0001561	0.63	NRP	curacomycin	Streptomyces curacoi
BGC0000348	0.62	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000876	0.61	Other	neopolyoxin C	Streptomyces tendae

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 34051:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Arg)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

BAL15718.1

Search NORINE for peptide: strict or relaxed

AMP-binding (11..403): bLys

nrpys: bLys

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTEVVGTLVK
Nearest Stachelhaus code(s):: bLys DTEVVGTLVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

BAL15726.1

Search NORINE for peptide: strict or relaxed

AMP-binding (15..418): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVEEVGVVSK
Nearest Stachelhaus code(s):: Arg DVENVGVISK (59% 8Å match)
Stachelhaus code match:: 80% (moderate)

BAL15732.1

Search NORINE for peptide: strict or relaxed

AMP-binding (9..419): bLys

nrpys: bLys

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DTENVGTLVK
Nearest Stachelhaus code(s):: bLys DTENVGTLVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)