BGC0000433: surfactin biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1 - 41,884 nt. (total: 41,884 nt).
This entry is originally from NCBI GenBank AJ575642.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000433
Short description surfactin biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
Loci NCBI GenBank: AJ575642.1
Compounds
  • surfactin
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
surfactin
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C52H91N7O13
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE02619.1
  • yciC
 64 - 1341 (+) YciC protein
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  • CAE02620.1
  • yx01
 1406 - 2542 (+) Yx01 protein
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  • CAE02621.1
  • yckC
 2557 - 2991 (+) YckC protein
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  • CAE02622.1
  • yckD
 3064 - 3387 (+) YckD protein
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  • CAE02623.1
  • yckE
 3491 - 4927 (+) YckE protein
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  • CAE02624.1
  • nin
 4968 - 5366 (-) Nin
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  • CAE02625.1
  • nuc
 5387 - 5833 (-) NucA
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  • CAE02626.1
  • hxlB
 6183 - 6740 (-) HxlB protein
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  • CAE02627.1
  • hxlA
 6737 - 7372 (-) HxlA protein
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  • CAE02628.1
  • hxlR
 7604 - 7966 (+) transcriptional regulator
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  • CAE02629.1
  • xy02
 8150 - 8494 (-) Xy02 protein
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  • CAE02630.1
  • srfAA
 8558 - 19312 (+) surfactin synthetase A
  • Scaffold biosynthesis
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  • CAE02631.1
  • srfAB
 19334 - 30094 (+) surfactin synthetase B
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE02632.1
  • comS
 22467 - 22607 (+) competence protein S
  • Unknown
Sequence-based prediction
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  • CAE02633.1
  • srfAC
 30129 - 33965 (+) surfactin synthetase C
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE02634.1
  • srfAD
 33985 - 34716 (+) surfactin synthetase D
  • Other enzymatic
Sequence-based prediction
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  • CAE02635.1
  • aat
 34820 - 36148 (+) amino transferase
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  • CAE02636.1
  • ycxc
 36719 - 37855 (-) transporter
  • Transport
Sequence-based prediction
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  • CAE02637.1
  • ycxD
 37800 - 39110 (+) transcriptional regulator containing an aminotransferase domain
  • Regulation
Sequence-based prediction
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  • CAE02638.1
  • sfp
 39105 - 39779 (-) phosphopantetheinyl transferase involved in nonribosomal synthesis
  • Activation / processing
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  • CAE02639.1
  • yczE
 39878 - 40525 (-) integral membrane protein involved in nonribosomal synthesis
  • Unknown
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  • CAE02640.1
  • yckI
 40607 - 41350 (-) YckI protein
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  • CAE02641.1
  • yckJ
 41363 - 41869 (-) YckJ protein
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NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
NRP-synthases
Gene Modules
srfAA
Module 1
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 2
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
srfAB
Module 4
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 6
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
srfAC
Module 7
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Remove leading/trailing whitespace in gene identifiers
  • Corrected gene identifiers
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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