BGC0000434: SW-163C biosynthetic gene cluster from Streptomyces sp. SNA15896
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 55,697 nt. (total: 55,697 nt).
This entry is originally from NCBI GenBank AB375771.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000434
Short description SW-163C biosynthetic gene cluster from Streptomyces sp. SNA15896
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AB375771.1
Compounds
  • SW-163C
  • UK-63598
  • SW-163E
  • SW-163F
  • SW-163G
Species Streptomyces sp. SNA15896 [taxonomy]
References
Chemical products information
SW-163C
Copy SMILES
C52H60N10O14S2
Chemical database entries
NPAtlas
PubCHEM
UK-63598
Copy SMILES
C53H62N10O14S2
Chemical database entries
NPAtlas
SW-163E
Copy SMILES
C54H64N10O14S2
Chemical database entries
NPAtlas
PubCHEM
SW-163F
Copy SMILES
C55H66N10O14S2
Chemical database entries
NPAtlas
SW-163G
Copy SMILES
C56H68N10O14S2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAI63266.1
 165 - 2399 (+) putative oxidoreductase
copy AA seq
copy Nt seq
  • BAI63267.1
 3228 - 6521 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BAI63268.1
 8593 - 8793 (+) putative integral membrane protein
copy AA seq
copy Nt seq
  • BAI63269.1
 8921 - 9919 (-) putative 2-nitropropane dioxygenase
copy AA seq
copy Nt seq
  • BAI63270.1
 10431 - 11810 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BAI63271.1
 12010 - 12426 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BAI63272.1
 13117 - 14178 (+) hypothetical protein
copy AA seq
copy Nt seq
  • BAI63273.1
  • swb1
 14832 - 16079 (-) putative kynurenine aminotransferase
copy AA seq
copy Nt seq
  • BAI63274.1
  • swb2
 16199 - 16954 (-) putative oxidoreductase
copy AA seq
copy Nt seq
  • BAI63275.1
  • swb3
 17013 - 17795 (-) putative transcription regulator
copy AA seq
copy Nt seq
  • BAI63276.1
  • swb4
 17971 - 18960 (+) putative ABC transporter
copy AA seq
copy Nt seq
  • BAI63277.1
  • swb5
 18951 - 19781 (+) putative ABC transporter
copy AA seq
copy Nt seq
  • BAI63278.1
  • swb6
 19824 - 20993 (-) putative aminotransferase
copy AA seq
copy Nt seq
  • BAI63279.1
  • swb7
 20990 - 22426 (-) hypothetical protein
copy AA seq
copy Nt seq
  • BAI63280.1
  • swb8
 23253 - 23939 (+) putative SAM-dependent methyltransferase
copy AA seq
copy Nt seq
  • BAI63281.1
  • swb9
 23981 - 26020 (+) putative Mg-protoporphyrin IX monooxidative cyclase
copy AA seq
copy Nt seq
  • BAI63282.1
  • swb10
 26066 - 26761 (+) putative tryptophan 2,3-dioxygenase
copy AA seq
copy Nt seq
  • BAI63283.1
  • swb11
 26823 - 28571 (-) putative non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • BAI63284.1
  • swb12
 28689 - 30275 (-) putative peptide arylation enzyme
copy AA seq
copy Nt seq
  • BAI63285.1
  • swb13
 30122 - 31492 (-) putative cytochrome P450
copy AA seq
copy Nt seq
  • BAI63286.1
  • swb14
 31651 - 32397 (+) putative thioesterase
copy AA seq
copy Nt seq
  • BAI63287.1
  • swb15
 32468 - 34846 (-) UvrA-like protein
copy AA seq
copy Nt seq
  • BAI63288.1
  • swb16
 35089 - 42852 (+) putative non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • BAI63289.1
  • swb17
 42861 - 52334 (+) putative non-ribosomal peptide synthetase
copy AA seq
copy Nt seq
  • BAI63290.1
  • swb18
 52369 - 52581 (+) MbtH-like protein
copy AA seq
copy Nt seq
  • BAI63291.1
  • swb19
 52668 - 53180 (+) putative OmpR-family regulator
copy AA seq
copy Nt seq
  • BAI63292.1
  • swb20
 53285 - 54223 (-) putative oxidoreductase
copy AA seq
copy Nt seq
  • BAI63293.1
 54264 - 55697 (-) hypothetical protein
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
swb11
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
swb12
Module ?
Specificity: 3-hydroxyquinaldic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
swb16
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
swb17
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
Module ?
Specificity: norcoronamic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
  • Heterologous expression
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.