BGC0000434 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000434 (Streptomyces sp. SNA15896)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like,NRPS	1	55,697	SW-163C/UK-63598/SW-163E/SW-163F/SW-163G	NRPS:Type I	100%

BGC0000434 - Region 1 - NRPS,NRPS-like

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Location: 1 - 55,697 nt. (total: 55,697 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 55,698
Label		BGC0000434

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000434	1.67	NRP	SW-163C, UK-63598, SW-163E, SW-163F, SW-163G	Streptomyces sp. SNA15896
BGC0000343	0.74	NRP	enterobactin	Pseudomonas sp. J465
BGC0002493	0.72	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002474	0.71	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001561	0.70	NRP	curacomycin	Streptomyces curacoi
BGC0002043	0.68	RiPP	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0000457	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000900	0.64	Other	ferrichrome	Aspergillus oryzae
BGC0002476	0.63	NRP	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0000901	0.63	Other	ferrichrome	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000434	1.00	NRP	SW-163C, UK-63598, SW-163E, SW-163F, SW-163G	Streptomyces sp. SNA15896
BGC0000343	0.69	NRP	enterobactin	Pseudomonas sp. J465
BGC0002493	0.69	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002474	0.68	NRP	agrobactin	Agrobacterium tumefaciens
BGC0001561	0.68	NRP	curacomycin	Streptomyces curacoi
BGC0002043	0.67	RiPP	cittilin A, cittilin B	Myxococcus xanthus DK 1622
BGC0000457	0.66	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000460	0.66	NRP	vulnibactin	Vibrio vulnificus CMCP6
BGC0000901	0.66	Other	ferrichrome	Aspergillus niger
BGC0001434	0.66	NRP	nematophin	Xenorhabdus budapestensis

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 6822 - 55697:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp) + (D-Ser - Ala) + (NMe-Cys - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 6822 - 48571:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp) + (D-Ser - Ala) + (NMe-Cys - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 15088 - 55697:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Trp) + (D-Ser - Ala) + (NMe-Cys - NMe-X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

swb11

Search NORINE for peptide: strict or relaxed

AMP-binding (8..406): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTVTGVGK
Nearest Stachelhaus code(s):: Trp DAWTVTGVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

swb12

AMP-binding (32..429): X

nrpys: Hqa

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ALPTQGWLTK
Nearest Stachelhaus code(s):: Hqa ALPTQGWLTK (100% 8Å match); COOH-Qui ALPTQGWLTK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

swb16

Search NORINE for peptide: strict or relaxed

AMP-binding (475..868): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHVSLVDK
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2017..2397): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQITLIYK
Nearest Stachelhaus code(s):: Ala DILQITLIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

swb17

Search NORINE for peptide: strict or relaxed

AMP-binding (496..902): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNFSLVWK
Nearest Stachelhaus code(s):: Cys DLFNFSLVWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1954..2337): X

nrpys: norCMA

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DPYWWGATFK
Nearest Stachelhaus code(s):: norCMA DPYWWGATFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)