BGC0000435: syringafactin A biosynthetic gene cluster from Pseudomonas syringae pv. tomato str. DC3000
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 3,151,815 - 3,184,002 nt. (total: 32,188 nt).
This entry is originally from NCBI GenBank AE016853.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000435
Short description syringafactin A biosynthetic gene cluster from Pseudomonas syringae pv. tomato str. DC3000
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AE016853.1
3151815 - 3184002
via
Compounds
  • syringafactin A
  • syringafactin B
  • syringafactin C
  • syringafactin D
  • syringafactin E
  • syringafactin F
Species Pseudomonas syringae pv. tomato str. DC3000 [taxonomy]
References
Chemical products information
syringafactin A Evidence:
Copy SMILES
C54H99N9O13
Chemical database entries
NPAtlas
syringafactin B Evidence:
Copy SMILES
C55H101N9O13
Chemical database entries
NPAtlas
syringafactin C Evidence:
Copy SMILES
C55H101N9O13
Chemical database entries
NPAtlas
syringafactin D Evidence:
Copy SMILES
C56H103N9O13
Chemical database entries
NPAtlas
syringafactin E Evidence:
Copy SMILES
C57H105N9O13
Chemical database entries
NPAtlas
syringafactin F Evidence:
Copy SMILES
C57H105N9O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PSPTO_2828
  • AAO56327.1
  • syrR
 3151815 - 3152588 (-) transcriptional regulator SyrR
    copy AA seq
    copy Nt seq
    • PSPTO_2829
    • AAO56328.1
    • syfA
    		 3152879 - 3162385 (+) non-ribosomal peptide synthetase SyfA
      copy AA seq
      copy Nt seq
      • PSPTO_2830
      • AAO56329.1
      • syfB
      		 3162382 - 3180171 (+) non-ribosomal peptide synthetase SyfB
        copy AA seq
        copy Nt seq
        • PSPTO_2831
        • AAO56330.1
        • syfC
        		 3180168 - 3181319 (+) syringafactin efflux protein SyfC
          copy AA seq
          copy Nt seq
          • PSPTO_2832
          • AAO56331.1
          • syfD
          		 3181322 - 3183328 (+) syringafactin efflux protein SyfD
            copy AA seq
            copy Nt seq
            • PSPTO_2833
            • AAO56332.1
            		 3183334 - 3184002 (-) transcriptional regulator, LuxR family
              copy AA seq
              copy Nt seq
              Biosynthesis information

              Biosynthetic modules

              Name
              Unk01
              Type
              nrps-type1
              Genes
              syfA
              Substrates
              leucine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk02
              Type
              nrps-type1
              Genes
              syfA
              Substrates
              leucine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk03
              Type
              nrps-type1
              Genes
              syfA
              Substrates
              glutamine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk04
              Type
              nrps-type1
              Genes
              syfB
              Substrates
              leucine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk05
              Type
              nrps-type1
              Genes
              syfB
              Substrates
              threonine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk06
              Type
              nrps-type1
              Genes
              syfB
              Substrates
              valine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk07
              Type
              nrps-type1
              Genes
              syfB
              Substrates
              leucine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Name
              Unk08
              Type
              nrps-type1
              Genes
              syfB
              Substrates
              leucine (evidence: Mass spectrometry, Structure-based inference)
              Integrated Monomers
              Domains
              adenylation
              Annotation changelog

              Entry version: next

              Date
              Changes
              Submitters
              Reviewers
              2024-03-19
              MIBiG v4 annotathon
              • (ID: 7ZPV7YL7LI6WACA7MW4GA2DX)
              • (ID: CVBS4CX3MGQ2Y6Q45INSO263)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Updated bioactivity data
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Added NRP substrate specificities
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
              A domain glossary is available here, and an explanation of the visualisation is available here.
              Selected features only
              Show module domains
              Similar known gene clusters from MIBiG 4.0
              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
              Click on reference genes to show details of similarities to genes within the current region.
              Click on an accession to open that entry in the MiBIG database.