BGC0000437: syringomycin biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
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Location: 3,060,225 - 3,182,922 nt. (total: 122,698 nt).
This entry is originally from NCBI GenBank CP000075.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000437
Short description syringomycin biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CP000075.1
Compounds
  • syringomycin
Species Pseudomonas syringae pv. syringae B728a [taxonomy]
References
Chemical products information
syringomycin
Copy SMILES
C53H85Cl1N14O17
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Psyr_2606
  • AAY37645.1
 3060225 - 3061661 (-) RND efflux system, outer membrane lipoprotein, NodT
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  • Psyr_2607
  • AAY37646.1
 3061640 - 3062470 (-) regulatory protein, LuxR
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  • Psyr_2608
  • AAY37647.1
 3062695 - 3091191 (-) Amino acid adenylation
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  • Psyr_2609
  • AAY37648.1
 3091468 - 3092679 (-) Alpha/beta hydrolase fold protein
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  • Psyr_2610
  • AAY37649.1
 3092751 - 3093683 (-) Chlorinating enzyme
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  • Psyr_2611
  • AAY37650.1
 3093701 - 3095545 (-) Amino acid adenylation
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  • Psyr_2612
  • AAY37651.1
 3095877 - 3096938 (+) syrP protein, putative
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  • Psyr_2613
  • AAY37652.1
 3097019 - 3098719 (+) Cyclic peptide transporter
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  • Psyr_2614
  • AAY37653.1
 3098777 - 3114895 (+) Amino acid adenylation
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  • Psyr_2615
  • AAY37654.1
 3114892 - 3131301 (+) Amino acid adenylation
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  • Psyr_2616
  • AAY37655.1
 3131727 - 3172340 (+) Amino acid adenylation
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  • Psyr_2617
  • AAY37656.1
 3172404 - 3173561 (+) Secretion protein HlyD
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  • Psyr_2618
  • AAY37657.1
 3173564 - 3175525 (+) ABC transporter:Protein of unknown function DUF214
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  • Psyr_2619
  • AAY37658.1
 3175740 - 3177074 (-) diaminobutyrate aminotransferase apoenzyme
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  • Psyr_2620
  • AAY37659.1
 3177351 - 3178781 (+) RND efflux system, outer membrane lipoprotein, NodT
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  • Psyr_2621
  • AAY37660.1
 3178778 - 3179881 (+) Secretion protein HlyD
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  • Psyr_2622
  • AAY37661.1
 3179878 - 3182922 (+) Acriflavin resistance protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
Psyr_2608
Module ?
Specificity: serine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: serine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: arginine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • ATP-PPi exchange assay
Psyr_2611
Module ?
Specificity: threonine
Evidence for specificity:
  • ATP-PPi exchange assay
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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