BGC0000440: teicoplanin biosynthetic gene cluster from Actinoplanes teichomyceticus
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Location: 1 - 89,713 nt. (total: 89,713 nt).
This entry is originally from NCBI GenBank AJ605139.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000440
Short description teicoplanin biosynthetic gene cluster from Actinoplanes teichomyceticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Glycopeptide)
Loci NCBI GenBank: AJ605139.1
Compounds
  • teicoplanin
Species Actinoplanes teichomyceticus [taxonomy]
References
Chemical products information
teicoplanin
Copy SMILES
C58H45Cl2N7O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE53333.1
  • tei1
 41 - 529 (-) hypothetical protein
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  • CAE53334.1
  • tei2
 1369 - 1899 (-) hypothetical protein
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  • CAE53335.1
  • tei3
 2346 - 3476 (+) putative RCC1 repeats protein
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  • CAE53336.1
  • tei4
 3552 - 4628 (-) putative glucanase
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  • CAE53337.1
  • tei5
 5079 - 6608 (+) putative membrane zinc protease
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  • CAE53338.1
  • tei6
 6744 - 7079 (-) putative mannose-6-phosphate isomerase
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  • CAE53339.1
  • tei7
 7158 - 8123 (-) putative AraC-family transcription regulator
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  • CAE53340.1
  • tei8
 8427 - 9179 (-) putative TetR-family transcitpional regulator
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  • CAE53341.1
  • tei9
 9291 - 10025 (+) putative short chain dehydrogenase
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  • CAE53342.1
  • tcp1
 10677 - 12020 (+) murF-like protein
  • Resistance/immunity
Activity assay
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  • CAE53343.1
  • tcp2
 12042 - 13259 (+) VanH protein
  • Resistance/immunity
Other in vivo study
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  • CAE53344.1
  • tcp3
 13252 - 14289 (+) VanA protein
  • Resistance/immunity
Other in vivo study
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  • CAE53345.1
  • tcp4
 14289 - 14897 (+) VanX protein
  • Resistance/immunity
Other in vivo study
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  • CAE53346.1
  • tcp5
 15659 - 16198 (-) hypothetical protein
  • Unknown
Sequence-based prediction
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  • CAE53347.1
  • tcp6
 16311 - 17402 (-) transmamebrane sensor kinase
  • Regulation
Sequence-based prediction
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  • CAE53348.1
  • tcp7
 17410 - 18090 (-) response regulator
  • Regulation
Sequence-based prediction
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  • CAE53349.1
  • tcp8
 18949 - 20130 (+) GtfA protein
  • Tailoring (Glycosylation)
Activity assay
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  • CAE53350.1
  • tcp9
 20622 - 26852 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53351.1
  • tcp10
 26849 - 30034 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53352.1
  • tcp11
 30078 - 42281 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53353.1
  • tcp12
 42301 - 47898 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53354.1
  • tcp13
 47911 - 48120 (+) MbtH-like short polypeptide
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53355.1
  • tcp14
 48426 - 49247 (+) hypothetical protein
  • Tailoring (Hydrolysis)
Activity assay
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  • CAE53356.1
  • tcp15
 49293 - 51074 (+) putative mannosyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • CAE53357.1
  • tcp16
 51368 - 53314 (+) ABC transporter
  • Transport
Sequence-based prediction
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  • CAE53358.1
  • tcp17
 53401 - 53610 (+) MbtH-like short polypeptide
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53359.1
  • tcp18
 53721 - 54896 (+) OxyA protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53360.1
  • tcp19
 54919 - 56073 (+) Oxy protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53361.1
  • tcp20
 56063 - 57259 (+) OxyB protein
  • Scaffold biosynthesis
Activity assay
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  • CAE53362.1
  • tcp21
 57509 - 59029 (+) halogenase
  • Tailoring (Halogenation)
Sequence-based prediction
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  • CAE53363.1
  • tcp22
 59191 - 60369 (+) OxyC protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAE53364.1
  • tcp23
 60486 - 61712 (+) GtfB protein
  • Tailoring (Glycosylation)
Activity assay
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  • CAE53365.1
  • tcp24
 61858 - 62829 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • CAE53366.1
  • tcp25
 62973 - 64565 (+) putative non-haem hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • CAE53367.1
  • tcp26
 64782 - 66578 (+) acyl-CoA ligase
  • Tailoring (Acylation)
Activity assay
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  • CAE53368.1
  • tcp27
 66949 - 68004 (+) phospho-2-dehydro-3-deoxyheptonate aldolase, AroA type
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53369.1
  • tcp28
 68771 - 69760 (+) transcriptional regulator, StrR family
  • Regulation
Other in vivo study
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  • CAE53370.1
  • tcp29
 70502 - 72880 (+) transcriptional regulator, LuxR family
  • Regulation
Other in vivo study
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  • CAE53371.1
  • tcp30
 73061 - 74182 (+) DpgA protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53372.1
  • tcp31
 74179 - 74844 (+) DpgB protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53373.1
  • tcp32
 74841 - 76142 (+) DpgC protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53374.1
  • tcp33
 76171 - 76977 (+) DpgD protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53375.1
  • tcp34
 77016 - 78377 (+) membrane ion antiporter
  • Transport
Sequence-based prediction
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  • CAE53376.1
  • tcp35
 78374 - 78970 (+) putative GTP cyclohydrolase
  • Unknown
Sequence-based prediction
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  • CAE53377.1
  • tcp36
 79108 - 80205 (+) HpgT aminotransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53378.1
  • tcp37
 80291 - 81346 (+) HmaS protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53379.1
  • tcp38
 81343 - 82437 (+) Hmo protein
  • Precursor biosynthesis
Sequence-based prediction
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  • CAE53380.1
  • tcp39
 82573 - 83325 (+) thioesterase
  • Unknown
Sequence-based prediction
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  • CAE53381.1
  • tei10
 83908 - 85524 (+) transcriptional regulator, AfsR type
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  • CAE53382.1
  • tei11
 85781 - 86293 (+) hypothetical protein
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  • CAE53383.1
  • tei12
 86277 - 87170 (-) putative transposase, IS1650 family
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  • CAE53384.1
  • tei13
 88000 - 88941 (-) hypothetical protein
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  • CAE53385.1
  • tei14
 89052 - 89507 (+) putative transcriptional regulator, MerR family
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NRP-specific information
Subclass Glycopeptide
Cyclic? no
Release type
  • Hydrolysis
Thioesterase genes
  • tcp12 (Type I)
NRP-synthases
Gene Modules
tcp9
Module 1
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Sequence-based prediction
Module 2
Specificity: tyrosine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
tcp10
Module 3
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
tcp11
Module 4
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Module 5
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Module 6
Specificity: tyrosine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
tcp12
Module 7
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: Unknown
Modification domains: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: NELCJYN3677BXW76PLWVRCJG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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