BGC0000440: Teicoplanin A2-1 biosynthetic gene cluster from Actinoplanes teichomyceticus
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Location: 1 - 89,713 nt. (total: 89,713 nt).
This entry is originally from NCBI GenBank AJ605139.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000440
Short description Teicoplanin A2-1 biosynthetic gene cluster from Actinoplanes teichomyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AJ605139.1
via Enzymatic assays
Compounds
  • Teicoplanin A2-1
  • Teicoplanin A2-2
  • Teicoplanin A2-3
  • Teicoplanin A2-4
  • Teicoplanin A2-5
Species Actinoplanes teichomyceticus [taxonomy]
References
Chemical products information
Teicoplanin A2-1 Evidence: NMR [1], [2], [3]
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C88H95Cl2N9O33
Chemical database entries
NPAtlas
Teicoplanin A2-2 Evidence: NMR [1], [2], [3]
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C88H97Cl2N9O33
Chemical database entries
NPAtlas
Teicoplanin A2-3 Evidence: NMR [1], [2], [3]
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C88H97Cl2N9O33
Chemical database entries
NPAtlas
Teicoplanin A2-4 Evidence: NMR [1], [2], [3]
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C89H99Cl2N9O33
Chemical database entries
NPAtlas
Teicoplanin A2-5 Evidence: NMR [1], [2], [3]
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C89H99Cl2N9O33
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE53333.1
  • tei1
 41 - 529 (-) hypothetical protein
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    • CAE53334.1
    • tei2
    		 1369 - 1899 (-) hypothetical protein
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      • CAE53335.1
      • tei3
      		 2346 - 3476 (+) putative RCC1 repeats protein
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        • CAE53336.1
        • tei4
        		 3552 - 4628 (-) putative glucanase
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          • CAE53337.1
          • tei5
          		 5079 - 6608 (+) putative membrane zinc protease
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            • CAE53338.1
            • tei6
            		 6744 - 7079 (-) putative mannose-6-phosphate isomerase
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              • CAE53339.1
              • tei7
              		 7158 - 8123 (-) putative AraC-family transcription regulator
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                • CAE53340.1
                • tei8
                		 8427 - 9179 (-) putative TetR-family transcitpional regulator
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                  • CAE53341.1
                  • tei9
                  		 9291 - 10025 (+) putative short chain dehydrogenase
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                    • CAE53342.1
                    • tcp1
                    		 10677 - 12020 (+) murF-like protein
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                      • CAE53343.1
                      • tcp2
                      		 12042 - 13259 (+) VanH protein
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                        • CAE53344.1
                        • tcp3
                        		 13252 - 14289 (+) VanA protein
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                          • CAE53345.1
                          • tcp4
                          		 14289 - 14897 (+) VanX protein
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                            • CAE53346.1
                            • tcp5
                            		 15659 - 16198 (-) hypothetical protein
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                              • CAE53347.1
                              • tcp6
                              		 16311 - 17402 (-) transmamebrane sensor kinase
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                                • CAE53348.1
                                • tcp7
                                		 17410 - 18090 (-) response regulator
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                                  • CAE53349.1
                                  • tcp8
                                  		 18949 - 20130 (+) GtfA protein
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                                    • CAE53350.1
                                    • tcp9
                                    		 20622 - 26852 (+) non-ribosomal peptide synthetase
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                                      • CAE53351.1
                                      • tcp10
                                      		 26849 - 30034 (+) non-ribosomal peptide synthetase
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                                        • CAE53352.1
                                        • tcp11
                                        		 30078 - 42281 (+) non-ribosomal peptide synthetase
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                                          • CAE53353.1
                                          • tcp12
                                          		 42301 - 47898 (+) non-ribosomal peptide synthetase
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                                            • CAE53354.1
                                            • tcp13
                                            		 47911 - 48120 (+) MbtH-like short polypeptide
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                                              • CAE53355.1
                                              • tcp14
                                              		 48426 - 49247 (+) hypothetical protein
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                                                • CAE53356.1
                                                • tcp15
                                                		 49293 - 51074 (+) putative mannosyltransferase
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                                                  • CAE53357.1
                                                  • tcp16
                                                  		 51368 - 53314 (+) ABC transporter
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                                                    • CAE53358.1
                                                    • tcp17
                                                    		 53401 - 53610 (+) MbtH-like short polypeptide
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                                                      • CAE53359.1
                                                      • tcp18
                                                      		 53721 - 54896 (+) OxyA protein
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                                                        • CAE53360.1
                                                        • tcp19
                                                        		 54919 - 56073 (+) Oxy protein
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                                                          • CAE53361.1
                                                          • tcp20
                                                          		 56063 - 57259 (+) OxyB protein
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                                                            • CAE53362.1
                                                            • tcp21
                                                            		 57509 - 59029 (+) halogenase
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                                                              • CAE53363.1
                                                              • tcp22
                                                              		 59191 - 60369 (+) OxyC protein
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                                                                • CAE53364.1
                                                                • tcp23
                                                                		 60486 - 61712 (+) GtfB protein
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                                                                  • CAE53365.1
                                                                  • tcp24
                                                                  		 61858 - 62829 (+) hypothetical protein
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                                                                    • CAE53366.1
                                                                    • tcp25
                                                                    		 62973 - 64565 (+) putative non-haem hydroxylase
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                                                                      • CAE53367.1
                                                                      • tcp26
                                                                      		 64782 - 66578 (+) acyl-CoA ligase
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                                                                        • CAE53368.1
                                                                        • tcp27
                                                                        		 66949 - 68004 (+) phospho-2-dehydro-3-deoxyheptonate aldolase, AroA type
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                                                                          • CAE53369.1
                                                                          • tcp28
                                                                          		 68771 - 69760 (+) transcriptional regulator, StrR family
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                                                                            • CAE53370.1
                                                                            • tcp29
                                                                            		 70502 - 72880 (+) transcriptional regulator, LuxR family
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                                                                              • CAE53371.1
                                                                              • tcp30
                                                                              		 73061 - 74182 (+) DpgA protein
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                                                                                • CAE53372.1
                                                                                • tcp31
                                                                                		 74179 - 74844 (+) DpgB protein
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                                                                                  • CAE53373.1
                                                                                  • tcp32
                                                                                  		 74841 - 76142 (+) DpgC protein
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                                                                                    • CAE53374.1
                                                                                    • tcp33
                                                                                    		 76171 - 76977 (+) DpgD protein
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                                                                                      • CAE53375.1
                                                                                      • tcp34
                                                                                      		 77016 - 78377 (+) membrane ion antiporter
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                                                                                        • CAE53376.1
                                                                                        • tcp35
                                                                                        		 78374 - 78970 (+) putative GTP cyclohydrolase
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                                                                                          • CAE53377.1
                                                                                          • tcp36
                                                                                          		 79108 - 80205 (+) HpgT aminotransferase
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                                                                                            • CAE53378.1
                                                                                            • tcp37
                                                                                            		 80291 - 81346 (+) HmaS protein
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                                                                                              • CAE53379.1
                                                                                              • tcp38
                                                                                              		 81343 - 82437 (+) Hmo protein
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                                                                                                • CAE53380.1
                                                                                                • tcp39
                                                                                                		 82573 - 83325 (+) thioesterase
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                                                                                                  • CAE53381.1
                                                                                                  • tei10
                                                                                                  		 83908 - 85524 (+) transcriptional regulator, AfsR type
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                                                                                                    • CAE53382.1
                                                                                                    • tei11
                                                                                                    		 85781 - 86293 (+) hypothetical protein
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                                                                                                      • CAE53383.1
                                                                                                      • tei12
                                                                                                      		 86277 - 87170 (-) putative transposase, IS1650 family
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                                                                                                        • CAE53384.1
                                                                                                        • tei13
                                                                                                        		 88000 - 88941 (-) hypothetical protein
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                                                                                                          • CAE53385.1
                                                                                                          • tei14
                                                                                                          		 89052 - 89507 (+) putative transcriptional regulator, MerR family
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                                                                                                            Biosynthesis information

                                                                                                            Biosynthetic modules

                                                                                                            Name
                                                                                                            1
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp9
                                                                                                            Substrates
                                                                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            adenylation, epimerase
                                                                                                            Name
                                                                                                            2
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp9
                                                                                                            Substrates
                                                                                                            tyrosine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            condensation, adenylation, epimerase
                                                                                                            Name
                                                                                                            3
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp10
                                                                                                            Substrates
                                                                                                            3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            condensation, adenylation
                                                                                                            Name
                                                                                                            4
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp11
                                                                                                            Substrates
                                                                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            condensation, adenylation, epimerase
                                                                                                            Name
                                                                                                            5
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp11
                                                                                                            Substrates
                                                                                                            4-hydroxyphenylglycine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            condensation, adenylation, epimerase
                                                                                                            Name
                                                                                                            6
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp11
                                                                                                            Substrates
                                                                                                            tyrosine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            condensation, adenylation
                                                                                                            Name
                                                                                                            7
                                                                                                            Type
                                                                                                            nrps-type1
                                                                                                            Genes
                                                                                                            tcp12
                                                                                                            Substrates
                                                                                                            3,5-dihydroxyphenylglycine (evidence: Sequence-based prediction)
                                                                                                            Integrated Monomers
                                                                                                            Domains
                                                                                                            condensation, adenylation
                                                                                                            Annotation changelog

                                                                                                            Entry version: next

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2024-05-14
                                                                                                            MIBiG v4 annotathon
                                                                                                            • (ID: 37IOAS4X5OHP34DPN55OLFBF)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 4

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2022-10-07
                                                                                                            Update chemical activity to schema version 2.11
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 3

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2022-09-15
                                                                                                            Corrected NRP module activity
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            2022-09-15
                                                                                                            Corrected gene identifiers
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            2022-09-15
                                                                                                            Updated NRP substrate specificities
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 2

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2019-10-16
                                                                                                            Migrated from v1.4
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                            Entry version: 1

                                                                                                            Date
                                                                                                            Changes
                                                                                                            Submitters
                                                                                                            Reviewers
                                                                                                            2015-06-12
                                                                                                            Submitted
                                                                                                            • (ID: NELCJYN3677BXW76PLWVRCJG)
                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                            Detailed domain annotation
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