BGC0000441: teicoplanin biosynthetic gene cluster from Actinoplanes teichomyceticus
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Location: 1 - 89,976 nt. (total: 89,976 nt).
This entry is originally from NCBI GenBank AJ632270.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000441
Short description teicoplanin biosynthetic gene cluster from Actinoplanes teichomyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AJ632270.1
via
Compounds
  • teicoplanin
Species Actinoplanes teichomyceticus [taxonomy]
References
Chemical products information
teicoplanin Evidence:
Copy SMILES
C58H45Cl2N7O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG14998.1
 552 - 1517 (-) transcriptional regulator
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    • CAG14999.1
    		 1820 - 2572 (-) transcriptional regulator
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      • CAG15000.1
      		 2684 - 3418 (+) short chain dehydrogenase
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        • CAG15001.1
        		 4070 - 5413 (+) MurF-like protein
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          • CAG15002.1
          		 5612 - 6652 (+) D-lactate dehydrogenase
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            • CAG15003.1
            		 6645 - 7682 (+) ligase
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              • CAG15004.1
              		 7682 - 8290 (+) dipeptidase
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                • CAG15005.1
                		 9052 - 9591 (-) dihydrofolate reductase
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                  • CAG15006.1
                  		 9704 - 10795 (-) transcriptional regulator
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                    • CAG15007.1
                    		 10803 - 11483 (-) two component response regulator
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                      • CAG15008.1
                      		 12342 - 13523 (+) glycosyltransferase
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                        • CAG15009.1
                        • teiA
                        		 14015 - 20245 (+) peptide synthetase, module 1-2
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                          • CAG15010.1
                          • teiB
                          		 20242 - 23427 (+) peptide synthetase, module 3
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                            • CAG15011.1
                            • teiC
                            		 23471 - 35674 (+) peptide synthetase, module 4-6
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                              • CAG15012.1
                              • teiD
                              		 35694 - 41276 (+) peptide synthetase, module 7
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                                • CAG15013.1
                                		 41286 - 41498 (+) hypothetical protein
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                                  • CAG15014.1
                                  		 41804 - 42625 (+) hypothetical protein
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                                    • CAG15015.1
                                    		 42671 - 44452 (+) mannossyltransferase
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                                      • CAG15016.1
                                      		 44746 - 46692 (+) ABC transporter
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                                        • CAG15017.1
                                        		 47098 - 48273 (+) P450 monooxygenase
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                                          • CAG15018.1
                                          		 48296 - 49450 (+) P450 monooxygenase
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                                            • CAG15019.1
                                            		 49590 - 50636 (+) P450 monooxygenase
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                                              • CAG15020.1
                                              		 50931 - 52406 (+) halogenase
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                                                • CAG15021.1
                                                		 52502 - 53746 (+) P450 monooxygenase
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                                                  • CAG15022.1
                                                  		 53863 - 55089 (+) glycosyltransferase
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                                                    • CAG15023.1
                                                    		 55229 - 56206 (+) acyltransferase
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                                                      • CAG15024.1
                                                      		 56350 - 57942 (+) b-hydroxylase
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                                                        • CAG15025.1
                                                        		 58171 - 59955 (+) Acyl-CoA synthase
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                                                          • CAG15026.1
                                                          		 60326 - 61381 (+) heptulosonate synthase
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                                                            • CAG15027.1
                                                            		 62148 - 63137 (+) transcriptional regulator
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                                                              • CAG15028.1
                                                              		 63801 - 66257 (+) LuxR regulatory protein
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                                                                • CAG15029.1
                                                                		 66438 - 67559 (+) DpgA protein
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                                                                  • CAG15030.1
                                                                  		 67556 - 68221 (+) DpgB protein
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                                                                    • CAG15031.1
                                                                    		 68218 - 69519 (+) DpgC protein
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                                                                      • CAG15032.1
                                                                      		 69548 - 70354 (+) DpgD protein
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                                                                        • CAG15033.1
                                                                        		 70393 - 71754 (+) Na+-H+ antiporter
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                                                                          • CAG15034.1
                                                                          		 71751 - 72347 (+) GTP cyclohydrolase I
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                                                                            • CAG15035.1
                                                                            		 72485 - 73831 (+) HpgT protein
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                                                                              • CAG15036.1
                                                                              		 73867 - 74985 (+) prephenate dehydrogenase
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                                                                                • CAG15037.1
                                                                                		 75242 - 76780 (-) nonheme iron dioxygenase
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                                                                                  • CAG15038.1
                                                                                  		 76855 - 77142 (-) hypothetical protein
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                                                                                    • CAG15039.1
                                                                                    		 77365 - 78192 (+) hypothetical protein
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                                                                                      • CAG15040.1
                                                                                      		 78467 - 79528 (+) HmaS protein
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                                                                                        • CAG15041.1
                                                                                        		 79525 - 80619 (+) HmO protein
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                                                                                          • CAG15042.1
                                                                                          		 80755 - 81507 (+) thioesterase, type II
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                                                                                            • CAG15043.1
                                                                                            		 82083 - 83699 (+) transcriptional regulator
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                                                                                              • CAG15044.1
                                                                                              		 84452 - 85345 (-) transposase
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                                                                                                • CAG15045.1
                                                                                                		 86174 - 87115 (-) hypothetical protein
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                                                                                                  • CAG15046.1
                                                                                                  		 87764 - 88726 (+) manganese ABC transporter
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                                                                                                    Biosynthesis information

                                                                                                    Biosynthetic modules

                                                                                                    Name
                                                                                                    Unk01
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiA
                                                                                                    Substrates
                                                                                                    4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [1], [2])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Name
                                                                                                    Unk02
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiA
                                                                                                    Substrates
                                                                                                    tyrosine (evidence: ATP-PPi exchange assay [1], [3])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Name
                                                                                                    Unk03
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiB
                                                                                                    Substrates
                                                                                                    3,5-dihydroxyphenylglycine (evidence: ATP-PPi exchange assay [1], [4])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Name
                                                                                                    Unk04
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiC
                                                                                                    Substrates
                                                                                                    4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [1], [5])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Name
                                                                                                    Unk05
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiC
                                                                                                    Substrates
                                                                                                    4-hydroxyphenylglycine (evidence: ATP-PPi exchange assay [1], [6])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Name
                                                                                                    Unk06
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiC
                                                                                                    Substrates
                                                                                                    tyrosine (evidence: ATP-PPi exchange assay [1], [7])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Name
                                                                                                    Unk07
                                                                                                    Type
                                                                                                    nrps-type1
                                                                                                    Genes
                                                                                                    teiD
                                                                                                    Substrates
                                                                                                    3,5-dihydroxyphenylglycine (evidence: ATP-PPi exchange assay [1], [8])
                                                                                                    Integrated Monomers
                                                                                                    Domains
                                                                                                    adenylation
                                                                                                    Annotation changelog

                                                                                                    Entry version: 3

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2022-09-15
                                                                                                    Added NRP substrate specificities
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 2

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2019-10-16
                                                                                                    Migrated from v1.4
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                    Entry version: 1

                                                                                                    Date
                                                                                                    Changes
                                                                                                    Submitters
                                                                                                    Reviewers
                                                                                                    2015-06-12
                                                                                                    Submitted
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                    Detailed domain annotation
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