BGC0000441: teicoplanin biosynthetic gene cluster from Actinoplanes teichomyceticus
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Location: 1 - 89,976 nt. (total: 89,976 nt).
This entry is originally from NCBI GenBank AJ632270.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000441
Short description teicoplanin biosynthetic gene cluster from Actinoplanes teichomyceticus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: AJ632270.1
Compounds
  • teicoplanin
Species Actinoplanes teichomyceticus [taxonomy]
References
Chemical products information
teicoplanin
Copy SMILES
C58H45Cl2N7O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG14998.1
 552 - 1517 (-) transcriptional regulator
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  • CAG14999.1
 1820 - 2572 (-) transcriptional regulator
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  • CAG15000.1
 2684 - 3418 (+) short chain dehydrogenase
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  • CAG15001.1
 4070 - 5413 (+) MurF-like protein
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  • CAG15002.1
 5612 - 6652 (+) D-lactate dehydrogenase
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  • CAG15003.1
 6645 - 7682 (+) ligase
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  • CAG15004.1
 7682 - 8290 (+) dipeptidase
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  • CAG15005.1
 9052 - 9591 (-) dihydrofolate reductase
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  • CAG15006.1
 9704 - 10795 (-) transcriptional regulator
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  • CAG15007.1
 10803 - 11483 (-) two component response regulator
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  • CAG15008.1
 12342 - 13523 (+) glycosyltransferase
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  • CAG15009.1
  • teiA
 14015 - 20245 (+) peptide synthetase, module 1-2
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  • CAG15010.1
  • teiB
 20242 - 23427 (+) peptide synthetase, module 3
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  • CAG15011.1
  • teiC
 23471 - 35674 (+) peptide synthetase, module 4-6
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  • CAG15012.1
  • teiD
 35694 - 41276 (+) peptide synthetase, module 7
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  • CAG15013.1
 41286 - 41498 (+) hypothetical protein
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  • CAG15014.1
 41804 - 42625 (+) hypothetical protein
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  • CAG15015.1
 42671 - 44452 (+) mannossyltransferase
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  • CAG15016.1
 44746 - 46692 (+) ABC transporter
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  • CAG15017.1
 47098 - 48273 (+) P450 monooxygenase
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  • CAG15018.1
 48296 - 49450 (+) P450 monooxygenase
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  • CAG15019.1
 49590 - 50636 (+) P450 monooxygenase
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  • CAG15020.1
 50931 - 52406 (+) halogenase
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  • CAG15021.1
 52502 - 53746 (+) P450 monooxygenase
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  • CAG15022.1
 53863 - 55089 (+) glycosyltransferase
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  • CAG15023.1
 55229 - 56206 (+) acyltransferase
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  • CAG15024.1
 56350 - 57942 (+) b-hydroxylase
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  • CAG15025.1
 58171 - 59955 (+) Acyl-CoA synthase
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  • CAG15026.1
 60326 - 61381 (+) heptulosonate synthase
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  • CAG15027.1
 62148 - 63137 (+) transcriptional regulator
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  • CAG15028.1
 63801 - 66257 (+) LuxR regulatory protein
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  • CAG15029.1
 66438 - 67559 (+) DpgA protein
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  • CAG15030.1
 67556 - 68221 (+) DpgB protein
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  • CAG15031.1
 68218 - 69519 (+) DpgC protein
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  • CAG15032.1
 69548 - 70354 (+) DpgD protein
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  • CAG15033.1
 70393 - 71754 (+) Na+-H+ antiporter
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  • CAG15034.1
 71751 - 72347 (+) GTP cyclohydrolase I
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  • CAG15035.1
 72485 - 73831 (+) HpgT protein
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  • CAG15036.1
 73867 - 74985 (+) prephenate dehydrogenase
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  • CAG15037.1
 75242 - 76780 (-) nonheme iron dioxygenase
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  • CAG15038.1
 76855 - 77142 (-) hypothetical protein
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  • CAG15039.1
 77365 - 78192 (+) hypothetical protein
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  • CAG15040.1
 78467 - 79528 (+) HmaS protein
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  • CAG15041.1
 79525 - 80619 (+) HmO protein
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  • CAG15042.1
 80755 - 81507 (+) thioesterase, type II
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  • CAG15043.1
 82083 - 83699 (+) transcriptional regulator
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  • CAG15044.1
 84452 - 85345 (-) transposase
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  • CAG15045.1
 86174 - 87115 (-) hypothetical protein
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  • CAG15046.1
 87764 - 88726 (+) manganese ABC transporter
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
teiA
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: tyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
teiB
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
teiC
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Module ?
Specificity: tyrosine
Evidence for specificity:
  • ATP-PPi exchange assay
teiD
Module ?
Specificity: 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • ATP-PPi exchange assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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