Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000442.1:
Cluster 1NRP19759

BGC0000442, terrequinone biosynthetic gene cluster from Aspergillus nidulans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: terrequinone A
SMILES string: Copy to clipboard
Molecular formula: C32H30N2O3
Exact molecular mass: 490.22 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP
Nonribosomal peptide synthetases:
ABU51602
Module 1
A specificity: Indole pyruvic acid
Evidence for specificity: Activity assay
C domain subtype: N/A

Gene cluster description

terrequinone (BGC0000442). Gene Cluster 1. Biosynthetic class = NRP. GenBank BN001305, positions 732113-741871. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Dirk Hoffmeister (Friedrich-Schiller-University Jena)

Literature references

1. Bok JW et al. (2006) Genomic mining for Aspergillus natural products. Chem Biol 13(1):31-7. doi: 10.1016/j.chembiol.2005.10.008.
2. Schneider P et al. (2007) A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones. Chem Biol 14(6):635-44. doi: 10.1016/j.chembiol.2007.05.005.
3. Bouhired S et al. (2007) Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet Biol 44(11):1134-45. doi: 10.1016/j.fgb.2006.12.010. Epub
4. Schneider P et al. (2008) The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones. Fungal Genet Biol 45(3):302-9. doi: 10.1016/j.fgb.2007.09.004. Epub
5. Balibar CJ et al. (2007) Terrequinone A biosynthesis through L-tryptophan oxidation, dimerization and bisprenylation. Nat Chem Biol 3(9):584-92. doi: 10.1038/nchembio.2007.20. Epub 2007 Aug