BGC0000443: thanamycin biosynthetic gene cluster from Pseudomonas sp. SHC52
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Location: 1 - 40,038 nt. (total: 40,038 nt).
This entry is originally from NCBI GenBank HQ888764.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000443
Short description thanamycin biosynthetic gene cluster from Pseudomonas sp. SHC52
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HQ888764.1
via Knock-out studies
Compounds
  • thanamycin
Species Pseudomonas sp. SHC52 [taxonomy]
References
Chemical products information
thanamycin Evidence:
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C60H91Cl1N10O22
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AED89996.1
 65 - 949 (-) hypothetical protein
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    • AED89997.1
    		 984 - 1301 (-) HlyD family secretion protein
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      • AED89998.1
      		 1300 - 2094 (+) AraC family transcriptional regulator
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        • AED89999.1
        		 2143 - 2754 (-) putative aspartyl b-hydroxylase
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          • AED90000.1
          		 2872 - 4242 (-) putative MFS transporter
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            • AED90001.1
            		 4239 - 5243 (-) putative transcription factor
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              • AED90002.1
              		 5609 - 21733 (+) non-ribosomal peptide synthetase ThaA
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                • AED90003.1
                		 21737 - 35314 (+) non-ribosomal peptide synthetase ThaB
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                  • AED90004.1
                  		 35640 - 37484 (+) non-ribosomal peptide synthetase ThaC1
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                    • AED90005.1
                    		 37502 - 38437 (+) non-ribosomal peptide synthetase ThaC2
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                      • AED90006.1
                      		 38497 - 39708 (+) non-ribosomal peptide synthetase ThaD
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                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        1
                        Type
                        nrps-type1
                        Genes
                        AED90002.1
                        Substrates
                        serine (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        2
                        Type
                        nrps-type1
                        Genes
                        AED90002.1
                        Substrates
                        ornithine (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        3
                        Type
                        nrps-type1
                        Genes
                        AED90002.1
                        Substrates
                        aspartic acid (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        4
                        Type
                        nrps-type1
                        Genes
                        AED90002.1
                        Substrates
                        homoserine (evidence: Structure-based inference [1], [2])
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        5
                        Type
                        nrps-type1
                        Genes
                        AED90002.1
                        Substrates
                        histidine (evidence: Structure-based inference [1], [2])
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        7
                        Type
                        nrps-type1
                        Genes
                        AED90003.1
                        Substrates
                        threonine (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        8
                        Type
                        nrps-type1
                        Genes
                        AED90003.1
                        Substrates
                        aspartic acid, 3-hydroxyaspartic acid (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        9
                        Type
                        nrps-type1
                        Genes
                        AED90003.1
                        Substrates
                        4-chlorothreonine, threonine (evidence: Structure-based inference)
                        Integrated Monomers
                        Domains
                        condensation, adenylation
                        Name
                        10
                        Type
                        nrps-type1
                        Genes
                        AED90004.1
                        Substrates
                        threonine (evidence: Sequence-based prediction)
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Corrected NRP module activity
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                        2022-09-15
                        Corrected gene identifiers
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                        2022-09-15
                        Fixed NRP substrates
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                        2022-09-15
                        Updated NRP substrate specificities
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                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
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                        2019-10-16
                        Updated compound(s) information (MIBiG Annotathon)
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                        2019-10-16
                        Updated compound(s) information (NPAtlas curation)
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                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: H2TUQKOCLKJUFX3XAH52M5HN)
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